Adult learning online education:
Adult learning online education:
Adult learning online education:
About the example: Boolean searches were conducted on November 4, 2019; result numbers may vary at a later date. No additional database limiters were set to further narrow search returns.
Database strategies for targeted search results.
Most databases include limiters, or additional parameters, you may use to strategically focus search results. EBSCO databases, such as Education Research Complete & Academic Search Complete provide options to:
Keep in mind that these tools are defined as limiters for a reason; adding them to a search will limit the number of results returned. This can be a double-edged sword. How?
Use limiters with care. When starting a search, consider opting out of limiters until the initial literature screening is complete. The second or third time through your research may be the ideal time to focus on specific time periods or material (scholarly vs newspaper).
Expanding your search term at the root.
Truncating is often referred to as 'wildcard' searching. Databases may have their own specific wildcard elements however, the most commonly used are the asterisk (*) or question mark (?). When used within your search. they will expand returned results.
Using the asterisk wildcard will return varied spellings of the truncated word. In the following example, the search term education was truncated after the letter "t."
Original Search | |
adult education | adult educat* |
Results included: educate, education, educator, educators'/educators, educating, & educational |
Explore these database help pages for additional information on crafting search terms.
Tips for saving research directly to Google drive.
It is possible to save articles (PDF and HTML) and abstracts in EBSCOhost databases directly to Google drive. Select the Google Drive icon, authenticate using a Google account, and an EBSCO folder will be created in your account. This is a great option for managing your research. If documenting your research in a Google Doc, consider linking the information to actual articles saved in drive.
EBSCOHost Databases & Google Drive: Managing your Research
This video features an overview of how to use Google Drive with EBSCO databases to help manage your research. It presents information for connecting an active Google account to EBSCO and steps needed to provide permission for EBSCO to manage a folder in Drive.
About the Video: Closed captioning is available, select CC from the video menu. If you need to review a specific area on the video, view on YouTube and expand the video description for access to topic time stamps. A video transcript is provided below.
What is a literature review.
A definition from the Online Dictionary for Library and Information Sciences .
A literature review is "a comprehensive survey of the works published in a particular field of study or line of research, usually over a specific period of time, in the form of an in-depth, critical bibliographic essay or annotated list in which attention is drawn to the most significant works" (Reitz, 2014).
A systemic review is "a literature review focused on a specific research question, which uses explicit methods to minimize bias in the identification, appraisal, selection, and synthesis of all the high-quality evidence pertinent to the question" (Reitz, 2014).
EBSCO Connect [Discovery and Search]. (2022). Searching with boolean operators. Retrieved May, 3, 2022 from https://connect.ebsco.com/s/?language=en_US
EBSCO Connect [Discover and Search]. (2022). Searching with wildcards and truncation symbols. Retrieved May 3, 2022; https://connect.ebsco.com/s/?language=en_US
Machi, L.A. & McEvoy, B.T. (2009). The literature review . Thousand Oaks, CA: Corwin Press:
Reitz, J.M. (2014). Online dictionary for library and information science. ABC-CLIO, Libraries Unlimited . Retrieved from https://www.abc-clio.com/ODLIS/odlis_A.aspx
Ridley, D. (2008). The literature review: A step-by-step guide for students . Thousand Oaks, CA: Sage Publications, Inc.
Schedule an appointment.
Contact a librarian directly (email), or submit a request form. If you have worked with someone before, you can request them on the form.
https://doi.org/10.1136/eb-2018-102996
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Some nurses feel that they lack the necessary skills to read a research paper and to then decide if they should implement the findings into their practice. This is particularly the case when considering the results of quantitative research, which often contains the results of statistical testing. However, nurses have a professional responsibility to critique research to improve their practice, care and patient safety. 1 This article provides a step by step guide on how to critically appraise a quantitative paper.
The authors’ names may not mean much, but knowing the following will be helpful:
Their position, for example, academic, researcher or healthcare practitioner.
Their qualification, both professional, for example, a nurse or physiotherapist and academic (eg, degree, masters, doctorate).
This can indicate how the research has been conducted and the authors’ competence on the subject. Basically, do you want to read a paper on quantum physics written by a plumber?
The abstract is a resume of the article and should contain:
Introduction.
Research question/hypothesis.
Methods including sample design, tests used and the statistical analysis (of course! Remember we love numbers).
Main findings.
Conclusion.
The subheadings in the abstract will vary depending on the journal. An abstract should not usually be more than 300 words but this varies depending on specific journal requirements. If the above information is contained in the abstract, it can give you an idea about whether the study is relevant to your area of practice. However, before deciding if the results of a research paper are relevant to your practice, it is important to review the overall quality of the article. This can only be done by reading and critically appraising the entire article.
Example: the effect of paracetamol on levels of pain.
My hypothesis is that A has an effect on B, for example, paracetamol has an effect on levels of pain.
My null hypothesis is that A has no effect on B, for example, paracetamol has no effect on pain.
My study will test the null hypothesis and if the null hypothesis is validated then the hypothesis is false (A has no effect on B). This means paracetamol has no effect on the level of pain. If the null hypothesis is rejected then the hypothesis is true (A has an effect on B). This means that paracetamol has an effect on the level of pain.
The literature review should include reference to recent and relevant research in the area. It should summarise what is already known about the topic and why the research study is needed and state what the study will contribute to new knowledge. 5 The literature review should be up to date, usually 5–8 years, but it will depend on the topic and sometimes it is acceptable to include older (seminal) studies.
In quantitative studies, the data analysis varies between studies depending on the type of design used. For example, descriptive, correlative or experimental studies all vary. A descriptive study will describe the pattern of a topic related to one or more variable. 6 A correlational study examines the link (correlation) between two variables 7 and focuses on how a variable will react to a change of another variable. In experimental studies, the researchers manipulate variables looking at outcomes 8 and the sample is commonly assigned into different groups (known as randomisation) to determine the effect (causal) of a condition (independent variable) on a certain outcome. This is a common method used in clinical trials.
There should be sufficient detail provided in the methods section for you to replicate the study (should you want to). To enable you to do this, the following sections are normally included:
Overview and rationale for the methodology.
Participants or sample.
Data collection tools.
Methods of data analysis.
Ethical issues.
Data collection should be clearly explained and the article should discuss how this process was undertaken. Data collection should be systematic, objective, precise, repeatable, valid and reliable. Any tool (eg, a questionnaire) used for data collection should have been piloted (or pretested and/or adjusted) to ensure the quality, validity and reliability of the tool. 9 The participants (the sample) and any randomisation technique used should be identified. The sample size is central in quantitative research, as the findings should be able to be generalised for the wider population. 10 The data analysis can be done manually or more complex analyses performed using computer software sometimes with advice of a statistician. From this analysis, results like mode, mean, median, p value, CI and so on are always presented in a numerical format.
The author(s) should present the results clearly. These may be presented in graphs, charts or tables alongside some text. You should perform your own critique of the data analysis process; just because a paper has been published, it does not mean it is perfect. Your findings may be different from the author’s. Through critical analysis the reader may find an error in the study process that authors have not seen or highlighted. These errors can change the study result or change a study you thought was strong to weak. To help you critique a quantitative research paper, some guidance on understanding statistical terminology is provided in table 1 .
Some basic guidance for understanding statistics
Quantitative studies examine the relationship between variables, and the p value illustrates this objectively. 11 If the p value is less than 0.05, the null hypothesis is rejected and the hypothesis is accepted and the study will say there is a significant difference. If the p value is more than 0.05, the null hypothesis is accepted then the hypothesis is rejected. The study will say there is no significant difference. As a general rule, a p value of less than 0.05 means, the hypothesis is accepted and if it is more than 0.05 the hypothesis is rejected.
The CI is a number between 0 and 1 or is written as a per cent, demonstrating the level of confidence the reader can have in the result. 12 The CI is calculated by subtracting the p value to 1 (1–p). If there is a p value of 0.05, the CI will be 1–0.05=0.95=95%. A CI over 95% means, we can be confident the result is statistically significant. A CI below 95% means, the result is not statistically significant. The p values and CI highlight the confidence and robustness of a result.
The final section of the paper is where the authors discuss their results and link them to other literature in the area (some of which may have been included in the literature review at the start of the paper). This reminds the reader of what is already known, what the study has found and what new information it adds. The discussion should demonstrate how the authors interpreted their results and how they contribute to new knowledge in the area. Implications for practice and future research should also be highlighted in this section of the paper.
A few other areas you may find helpful are:
Limitations of the study.
Conflicts of interest.
Table 2 provides a useful tool to help you apply the learning in this paper to the critiquing of quantitative research papers.
Quantitative paper appraisal checklist
Competing interests None declared.
Patient consent Not required.
Provenance and peer review Commissioned; internally peer reviewed.
Correction notice This article has been updated since its original publication to update p values from 0.5 to 0.05 throughout.
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Methodology
Published on April 12, 2019 by Raimo Streefkerk . Revised on June 22, 2023.
When collecting and analyzing data, quantitative research deals with numbers and statistics, while qualitative research deals with words and meanings. Both are important for gaining different kinds of knowledge.
Common quantitative methods include experiments, observations recorded as numbers, and surveys with closed-ended questions.
Quantitative research is at risk for research biases including information bias , omitted variable bias , sampling bias , or selection bias . Qualitative research Qualitative research is expressed in words . It is used to understand concepts, thoughts or experiences. This type of research enables you to gather in-depth insights on topics that are not well understood.
Common qualitative methods include interviews with open-ended questions, observations described in words, and literature reviews that explore concepts and theories.
The differences between quantitative and qualitative research, data collection methods, when to use qualitative vs. quantitative research, how to analyze qualitative and quantitative data, other interesting articles, frequently asked questions about qualitative and quantitative research.
Quantitative and qualitative research use different research methods to collect and analyze data, and they allow you to answer different kinds of research questions.
Quantitative and qualitative data can be collected using various methods. It is important to use a data collection method that will help answer your research question(s).
Many data collection methods can be either qualitative or quantitative. For example, in surveys, observational studies or case studies , your data can be represented as numbers (e.g., using rating scales or counting frequencies) or as words (e.g., with open-ended questions or descriptions of what you observe).
However, some methods are more commonly used in one type or the other.
A rule of thumb for deciding whether to use qualitative or quantitative data is:
For most research topics you can choose a qualitative, quantitative or mixed methods approach . Which type you choose depends on, among other things, whether you’re taking an inductive vs. deductive research approach ; your research question(s) ; whether you’re doing experimental , correlational , or descriptive research ; and practical considerations such as time, money, availability of data, and access to respondents.
You survey 300 students at your university and ask them questions such as: “on a scale from 1-5, how satisfied are your with your professors?”
You can perform statistical analysis on the data and draw conclusions such as: “on average students rated their professors 4.4”.
You conduct in-depth interviews with 15 students and ask them open-ended questions such as: “How satisfied are you with your studies?”, “What is the most positive aspect of your study program?” and “What can be done to improve the study program?”
Based on the answers you get you can ask follow-up questions to clarify things. You transcribe all interviews using transcription software and try to find commonalities and patterns.
You conduct interviews to find out how satisfied students are with their studies. Through open-ended questions you learn things you never thought about before and gain new insights. Later, you use a survey to test these insights on a larger scale.
It’s also possible to start with a survey to find out the overall trends, followed by interviews to better understand the reasons behind the trends.
Qualitative or quantitative data by itself can’t prove or demonstrate anything, but has to be analyzed to show its meaning in relation to the research questions. The method of analysis differs for each type of data.
Quantitative data is based on numbers. Simple math or more advanced statistical analysis is used to discover commonalities or patterns in the data. The results are often reported in graphs and tables.
Applications such as Excel, SPSS, or R can be used to calculate things like:
Qualitative data is more difficult to analyze than quantitative data. It consists of text, images or videos instead of numbers.
Some common approaches to analyzing qualitative data include:
If you want to know more about statistics , methodology , or research bias , make sure to check out some of our other articles with explanations and examples.
Research bias
Quantitative research deals with numbers and statistics, while qualitative research deals with words and meanings.
Quantitative methods allow you to systematically measure variables and test hypotheses . Qualitative methods allow you to explore concepts and experiences in more detail.
In mixed methods research , you use both qualitative and quantitative data collection and analysis methods to answer your research question .
The research methods you use depend on the type of data you need to answer your research question .
Data collection is the systematic process by which observations or measurements are gathered in research. It is used in many different contexts by academics, governments, businesses, and other organizations.
There are various approaches to qualitative data analysis , but they all share five steps in common:
The specifics of each step depend on the focus of the analysis. Some common approaches include textual analysis , thematic analysis , and discourse analysis .
A research project is an academic, scientific, or professional undertaking to answer a research question . Research projects can take many forms, such as qualitative or quantitative , descriptive , longitudinal , experimental , or correlational . What kind of research approach you choose will depend on your topic.
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Streefkerk, R. (2023, June 22). Qualitative vs. Quantitative Research | Differences, Examples & Methods. Scribbr. Retrieved June 26, 2024, from https://www.scribbr.com/methodology/qualitative-quantitative-research/
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In the realm of academia and intellectual discourse, the art of critiquing articles holds significant importance. It not only refines one’s skills but also contributes to the growth of knowledge. A well-executed article critique showcases your ability to analyze, evaluate, and engage with scholarly work. This article delves into the concept of article critiques, offering insights into their purpose and benefits, along with a step-by-step guide on how to craft one effectively.
An article critique is a detailed evaluation and analysis of a scholarly article or research paper . It involves an objective assessment of the author’s arguments, evidence, methodology, and conclusions. An effective critique goes beyond summarizing the content; it delves into the strengths, weaknesses, and implications of the article. Developing this skill allows you to identify the characteristics that contribute to a compelling scholarly work, while also honing your ability to engage critically with academic literature.
1. introduction.
A. structure and organization.
Psychology article critique.
Reference: Smith, J. A., & Brown, R. L. (2022). The impact of sleep deprivation on cognitive performance. Journal of Psychological Research , 34(2), 123-135. https://doi.org/10.1001/jpsychres.2022.01.001 Introduction In their article “The Impact of Sleep Deprivation on Cognitive Performance,” Smith and Brown (2022) examine the effects of sleep deprivation on various cognitive functions. The authors aim to highlight the importance of adequate sleep for maintaining cognitive health and performance. Summary Smith and Brown (2022) conducted a series of cognitive tests on participants who were sleep-deprived for 24 hours. The results indicated significant declines in memory retention, attention span, and problem-solving skills among the sleep-deprived group. The article also discusses potential long-term consequences of chronic sleep deprivation on brain health. Critique Smith and Brown (2022) provide compelling evidence linking sleep deprivation to cognitive decline. Their methodology is robust, featuring a well-defined participant group and controlled variables. However, the study’s sample size is relatively small, which may limit the generalizability of the findings. Additionally, the article does not sufficiently explore potential confounding factors, such as stress and caffeine intake, which could influence cognitive performance. Conclusion Overall, Smith and Brown (2022) effectively underscore the critical role of sleep in cognitive health. Despite some methodological limitations, their findings contribute valuable insights to the field of sleep research. Future studies should aim to address the identified limitations to strengthen the generalizability and applicability of the results.
Reference: Johnson, L. M., & White, P. D. (2023). The impact of technology integration on student learning outcomes. Journal of Educational Technology , 29(1), 45-59. https://doi.org/10.1016/j.jeduc.2023.01.002 Introduction In the article “The Impact of Technology Integration on Student Learning Outcomes,” Johnson and White (2023) explore how incorporating digital tools and resources in the classroom affects students’ academic performance. The authors aim to identify both the benefits and challenges of technology integration in education. Summary Johnson and White (2023) evaluate various forms of technology integration, including interactive whiteboards, educational software, and online resources. They analyze the effects of these tools on student engagement, motivation, and achievement across different subjects and grade levels. The study presents data from several schools that have implemented these technologies, showing improvements in test scores and classroom participation. Critique The article by Johnson and White (2023) provides a comprehensive analysis of the positive impacts of technology on student learning. The use of multiple case studies strengthens the validity of their conclusions. However, the study’s focus on urban schools may not reflect the experiences of students in rural or underfunded schools, limiting the generalizability of the findings. Additionally, the reliance on short-term data does not capture the long-term effects of technology integration on student learning. Conclusion Johnson and White (2023) make a compelling case for the positive impact of technology on student learning outcomes. While the article effectively demonstrates the benefits of digital tools, addressing the identified limitations would provide a more comprehensive understanding of technology integration in education. Future research should focus on long-term effects, diverse educational settings, and the challenges of teacher training and equitable access to technology.
Reference: Davis, K. L., & Roberts, J. H. (2021). Corporate social responsibility and business success: A review of recent research. Journal of Business Ethics , 38(4), 220-235. https://doi.org/10.1016/j.jbuseth.2021.02.003 Introduction In their article “Corporate Social Responsibility and Business Success: A Review of Recent Research,” Davis and Roberts (2021) explore how corporate social responsibility (CSR) initiatives impact business performance. The authors aim to demonstrate the benefits of CSR in enhancing corporate reputation and customer loyalty. Summary Davis and Roberts (2021) review several studies that analyze the outcomes of CSR initiatives across different industries. The article highlights positive correlations between CSR activities and financial performance, as well as improvements in brand reputation and customer satisfaction. The authors also discuss the potential challenges businesses face when implementing CSR programs. Critique Davis and Roberts (2021) provide a thorough review of the literature on CSR and its impact on business success. The article effectively synthesizes findings from various studies, supporting their argument that CSR can be beneficial for companies. However, the article could be improved by including more critical perspectives on CSR, such as potential drawbacks or instances where CSR initiatives have failed. Additionally, the authors do not provide detailed guidelines on how companies can measure the effectiveness of their CSR efforts. Conclusion Overall, Davis and Roberts (2021) make a strong case for the positive impact of CSR on business success. Their review underscores the importance of socially responsible practices in building a positive corporate image and achieving long-term profitability. Future research should address the limitations noted, particularly by exploring the challenges and failures of CSR initiatives and providing actionable metrics for evaluating their success.
Reference: Nguyen, M. T., & Kim, H. S. (2020). The effects of a plant-based diet on cardiovascular health: A systematic review. Journal of Nutritional Science , 17(3), 95-110. https://doi.org/10.1016/j.jnutrsci.2020.03.005 Introduction In the article “The Effects of a Plant-Based Diet on Cardiovascular Health: A Systematic Review,” Nguyen and Kim (2020) investigate the impact of plant-based diets on heart disease prevention and management. The authors aim to provide evidence supporting dietary recommendations for cardiovascular health. Summary Nguyen and Kim (2020) review multiple studies comparing the cardiovascular outcomes of individuals on plant-based diets versus those on omnivorous diets. Their findings suggest that plant-based diets are associated with lower cholesterol levels, reduced blood pressure, and decreased incidence of heart disease. The authors discuss potential mechanisms, such as reduced intake of saturated fats and increased consumption of fiber and antioxidants. Critique Nguyen and Kim (2020) present a comprehensive review of the cardiovascular benefits of plant-based diets. The inclusion of various studies strengthens the validity of their conclusions. However, the review would benefit from a more balanced discussion of potential challenges, such as the risk of nutrient deficiencies and the social and cultural barriers to adopting a plant-based diet. Additionally, the article focuses primarily on short-term studies, and more research on the long-term sustainability of these diets is needed. Conclusion Overall, Nguyen and Kim (2020) provide strong evidence supporting the cardiovascular benefits of plant-based diets. Their systematic review contributes valuable insights to the field of nutritional science. Future research should address the limitations identified, particularly regarding long-term sustainability and potential challenges in adhering to plant-based diets.
Reference: Lopez, G. R., & Thompson, S. L. (2021). Urban poverty and social policy: Examining the effectiveness of welfare programs. Journal of Social Policy , 43(2), 180-195. https://doi.org/10.1016/j.jsp.2021.04.007 Introduction In the article “Urban Poverty and Social Policy: Examining the Effectiveness of Welfare Programs,” Lopez and Thompson (2021) analyze the impact of various welfare programs on reducing urban poverty. The authors aim to assess the effectiveness of these programs in improving the socioeconomic conditions of urban populations. Summary Lopez and Thompson (2021) evaluate several welfare programs, including food assistance, housing subsidies, and employment training initiatives. Their analysis reveals mixed outcomes, with some programs showing significant positive effects on poverty reduction, while others have minimal impact. The authors discuss factors contributing to these varied results, such as program design, implementation quality, and participant engagement. Critique Lopez and Thompson (2021) provide a detailed analysis of the effectiveness of welfare programs in addressing urban poverty. The article’s strength lies in its comprehensive evaluation of multiple programs and consideration of various influencing factors. However, the study relies on data from a limited number of cities, which may not be representative of broader urban contexts. Additionally, the authors could have included more qualitative data to provide deeper insights into the lived experiences of program participants. Conclusion Overall, Lopez and Thompson (2021) offer valuable insights into the effectiveness of welfare programs in reducing urban poverty. Their findings highlight the need for well-designed and effectively implemented programs to achieve meaningful poverty reduction. Future research should aim to include a more diverse range of urban settings and incorporate qualitative data to enrich the understanding of program impacts.
Psychology article critique thesis statements.
Article Title : The Impact of Technology Integration on Student Learning Outcomes Introduction The article “The Impact of Technology Integration on Student Learning Outcomes” investigates how the use of digital tools and resources in the classroom influences students’ academic performance. The research aims to identify the benefits and potential drawbacks of incorporating technology into educational settings. Summary The study evaluates various forms of technology integration, including interactive whiteboards, educational software, and online resources. It examines their effects on student engagement, motivation, and achievement across different subjects and grade levels. The article presents data from several schools that have implemented these technologies, showcasing improvements in test scores and classroom participation. Critique The article provides a comprehensive analysis of the positive impacts of technology on student learning. The use of multiple case studies strengthens the validity of its conclusions. However, the article could improve by addressing some critical aspects: Sample Size and Diversity : The study primarily focuses on schools in urban areas, which may not reflect the experiences of students in rural or underfunded schools. Expanding the sample size to include a more diverse range of schools would enhance the generalizability of the findings. Longitudinal Data : The research relies heavily on short-term data, which may not capture the long-term effects of technology integration on student learning. Longitudinal studies are necessary to understand the sustained impact of these tools. Teacher Training and Support : While the article highlights the benefits of technology, it overlooks the challenges teachers face in integrating these tools effectively. Providing adequate training and ongoing support is crucial for the successful implementation of technology in the classroom. Equity and Access : The article briefly mentions the digital divide but does not delve into how disparities in access to technology can affect educational outcomes. A more thorough examination of equity issues would provide a balanced perspective on the advantages and limitations of technology integration. Conclusion Overall, the article makes a compelling case for the positive impact of technology on student learning outcomes. It effectively demonstrates how digital tools can enhance engagement and academic performance. However, to provide a more comprehensive understanding, future research should address the limitations identified, particularly regarding sample diversity, long-term effects, teacher support, and equity issues. By doing so, the research could offer more actionable insights for policymakers and educators striving to harness the full potential of technology in education.
1. quantitative article critique.
An article critique serves multiple essential purposes in both academic and professional contexts. Below, we delve into the primary objectives of conducting an article critique, which are vital for developing critical thinking, analytical skills, and subject-specific knowledge.
Critical Evaluation:
Analytical Reasoning:
In-Depth Analysis:
Contextual Awareness:
Structured Writing:
Evidence-Based Arguments:
Constructive Criticism:
Quality Assurance:
Continual Improvement:
Adaptability:
An effective article critique includes several key components to ensure a thorough evaluation and analysis. Below are the main components:
Components:
Mastering the art of crafting an effective article critique requires a systematic approach. Here is a step-by-step guide to help you navigate this process with finesse.
Before diving into the critique, thoroughly read the article. Take notes on the main points, observation , objectives , and tone of the article. Identify the author’s goals and the case study , if applicable. This step is crucial for grasping the nuances of the work.
Evaluate the structure of the article. Identify the introduction, main arguments, supporting evidence, and conclusion. Examine the use of verbs and analogies , as well as the cause-and-effect relationships presented. Analyze how effectively the author communicates their ideas.
Scrutinize the methodology used by the author. Is it appropriate for the objectives of the article? Evaluate the quality and relevance of the evidence presented. Consider whether the evidence supports the author’s claims adequately.
Engage in a critical evaluation of the article. Identify its strengths and weaknesses. Does the author effectively address counterarguments? Are there any gaps in the logic? Assess the overall coherence and effectiveness of the article’s presentation.
It develops critical thinking, enhances understanding of the subject, improves academic writing skills, and provides constructive feedback.
Introduction, Summary, Analysis, Evaluation, Conclusion, and References.
Begin with an introduction that provides the article’s title, author, publication details, and a brief summary of its thesis and purpose.
Key points, research methods, findings, and conclusions of the article.
Examine the structure, content, logic, argumentation, methodology, and sources for clarity, relevance, and evidence strength.
Balanced assessment of the article’s strengths and weaknesses, and its contribution to the field.
Summarize your findings, provide an overall assessment, and offer suggestions for improvement or future research.
Follow the appropriate citation style (e.g., APA, MLA) and ensure all references are correctly formatted.
Avoid biased or overly negative reviews, lack of evidence for claims, and failure to provide a balanced perspective.
Use evidence to support your points, acknowledge both strengths and weaknesses, and avoid personal biases.
Text prompt
10 Examples of Public speaking
20 Examples of Gas lighting
BMC Infectious Diseases volume 24 , Article number: 608 ( 2024 ) Cite this article
99 Accesses
Metrics details
Planned behaviors and self-care against the coronavirus are two important factor in controlling its spread and self-care behaviors depend on the level of health literacy. This research was conducted to determine the mediating role of health literacy in the relationship between elements of planned behavior and self-care in dealing with the Covid-19.
In this descriptive-analytical quantitative study, the sample size was calculated using Cochrane’s formula and considering a p-value of 0.51, α = 0.05, and d = 0.05, and 313 students were selected based on stratified and random method. To gather data and assess various aspects of variables, a questionnaires were utilized, focusing on health literacy, self-car and planned behavior. The relationship between the variables was examined by SPSS version 26 and via descriptive statistics, including the mean and standard deviation, and inferential statistics such as Pearson’s correlation coefficient ( P = 0.05), path analysis, and determining the standard coefficients between self-care and planned behavior, mediated by the indicators of the health literacy.
A significant difference was found between the level of health literacy of women and men. The comparison of the mean health literacy and self-care behavior in terms of other variables did not show any significant difference. Meanwhile, the comparison of health status control behaviors, hand washing, and mask use did not show any significant difference between the two groups. A positive and significant correlation was found between self-care behaviors, attitude, subjective norms, perceived behavioral control, and behavioral intention. The relationship of health literacy and psychological variables of attitude, subjective norms, and perceived behavioral control with self-care against COVID-19 was significant.
The direct and significant impact of health literacy on individuals’ self-care behaviors against the coronavirus was not observed. However, health literacy did have a significant effect on subjective norms. This finding is important because subjective norms significantly influenced individuals’ behavioral intention, which in turn had a significant effect on self-care behaviors against the coronavirus. Thus, health literacy played a mediating role in this relationship. Furthermore, attitude emerged as the strongest predictor of behavioral intention, exerting a direct effect. Conversely, perceived behavioral control did not directly and significantly affect students’ self-care behaviors.
Peer Review reports
Self-care is a key control approach and a cognitive activity whereby people play a major role in maintaining their health. People’s ability to take care of themselves and adhere to the recommended protocols is the main method of preventing infection with the coronavirus [ 1 , 2 ]. Self-care against the coronavirus includes actions such as observing social distancing and wearing a mask. Awareness and adherence have played a significant role in controlling the COVID-19 pandemic. Self-care involves acquired, conscious, and purposeful actions that people undertake for the health of themselves, their children, and their families [ 3 , 4 ].
There is a direct link between self-care, adherence to medical and health recommendations, and health literacy [ 5 ]. Health literacy refers to people’s ability to receive, process, and comprehend health information, which can lead to better decision-making at different times [ 6 , 7 ]. It is a factor influencing people’s self-care for disease control and prevention. People’s low health literacy level and their inability to understand the information provided by health professionals can negatively impact their health and increase their medical expenses [ 4 ]. Accordingly, measuring health literacy can contribute to detecting people’s abilities and designing necessary educational interventions to improve their health literacy [ 8 ]. Therefore, paying attention to the link between health literacy and self-care against the coronavirus can prove a proper strategy to support preventive activities during the outbreak of such infectious diseases.
Given people’s health-related and behavioral problems in dealing with health challenges, theories and behavioral patterns can be employed to determine and identify the factors affecting health-related behaviors [ 9 ]. In fact, the use of theories to describe people’s behavior during health crises can enhance the efficiency, effectiveness, and chance of success in obtaining the desired outcomes [ 10 ]. Various guidelines and recommendations were emphasized during the COVID-19 outbreak, and people were expected to play a key role in self-care and control the spread of the virus by adhering to these guidelines; in practice, however, some communities did not succeed in this regard. There are various theories about health-related behaviors whose core deals with doing or not doing predetermined behaviors [ 11 , 12 , 13 ]. In the sphere of health, the theory of planned behavior (TPB) is a theory of behavior change whose efficiency and effectiveness have been proven in previous studies [ 14 , 15 ]. TPB asserts that individual beliefs regarding a specific behavior influence their attitude towards it, the prevailing subjective norms, and the perceived behavioral control, ultimately leading to the intention to engage in that behavior. TPB incorporated the concept of behavioral control as a crucial determinant of health behavior, alongside attitude and subjective norms. TPB establishes a causal chain linking beliefs (behavioral, normative, and control beliefs) to intentions and behaviors through attitudes, norms, and perceived control, providing a structured approach to identify key factors influencing an individual’s decision-making process. Given the changeability of beliefs and attitudes, they serve as prime targets for interventions aimed at modifying behavior [ 14 , 15 , 16 , 17 ].
In TPB, the main construct that determines behavior is the person’s intention, and the three constructs of attitude, subjective norms, and perceived behavioral control affect this intention [ 18 ]. Based on the TPB, the more favorable one’s attitude towards a behavior, the more likely the intention to perform the behavior. In this theory, subjective norms include a person’s subjective perception of others’ approval or disapproval of performing a behavior, and membership in support groups and increasing social support can lead to performing or not performing a certain behavior. Perceived behavioral control is the degree of control one feels to perform or not perform a behavior, which has a significant association with personal will [ 19 , 20 ]. The TPB has been employed in the domain of health, especially in patients’ self-care, and its efficacy has been confirmed in predicting and comprehending healthy and unhealthy behaviors and their related outcomes [ 1 , 2 , 5 , 15 , 19 ].
Overall, paying attention to planned behaviors and self-care against the coronavirus is a major factor in controlling its spread, and self-care behaviors depend on the level of health literacy. Although some studies have been conducted on health literacy and self-care behavior for different diseases [ 4 , 11 , 13 , 21 ]. This study was planned to determine the relationship between health literacy and self-care behavior, mediated by the constructs of planned behavior, was examined among students of Abadan University of Medical Sciences (Iran).
This descriptive-analytical quantitative study was conducted to determine the relationship between health information literacy, elements of planned behavior, and self-care in dealing with the coronavirus. The research population included all students studying at Abadan University of Medical Sciences (AbadanUMS) in the academic year 2022–2023 ( n = 1698). The sample size was calculated using Cochrane’s formula and considering a p-value of 0.51, α = 0.05, and d = 0.05, and 313 students were selected, divided by their fields of study. Sampling was stratified and random.
A four-part questionnaire was used to collect data. The first part include demographic characteristics such as sex, age, and a history of contracting the coronavirus. In the second part, to measure health literacy, the short form of the standard Health Literacy Questionnaire was used as the most common and comprehensive standard instrument for measuring health literacy [ 22 ]. This questionnaire has 33 items based on a Likert scale (from 1 = never to 5 = always); its validity is 0.83 (Cronbach’s coefficient), and its reliability has been confirmed (coefficient of 0.93) in previous studies [ 19 , 20 ]. In the third part, to measure the constituents of the TPB, 17 questions in four groups were considered to measure the scales of attitudes (Q1-Q3), subjective norms (Q4-Q6), perceived behavioral control (Q7-Q9), and behavioral intention (Q10-Q17), based on a five-point Likert scale (1 = completely agree to 5 = completely disagree). The content validity index (CVI = 0.83) and content validity ratio (CVR = 0.86) confirmed the face and content validity of this part of the questionnaire [ 23 , 24 ]. In the fourth part, a literature review was conducted, the accepted international protocols for self-care and preventing the spread of the coronavirus were extracted, and experts were consulted. This questionnaire include social distancing (Q1, Q7), vaccine injection (Q8), check health status (Q5, Q6), washing hands (Q3, Q4) and Use a disposable mask (Q2). The electronic form of this questionnaire was designed, and a link to it was sent to the participants.
SPSS (v. 26) was used for data analysis. The association between the variables was examined via descriptive statistics, including the mean and standard deviation (SD), and inferential statistics such as Pearson’s correlation coefficient ( P = 0.05), path analysis, and determining the standard coefficients between self-care behaviors and health literacy, mediated by the indicators of the TPB.
A total of nine student from the selected samples did not participate in this study. Table 1 shows the level of health literacy and self-care behavior based on different demographic characteristics of the 305 participants. Most of the participants were women, aged 18–20 years, and were seniors. A significant difference was found between the level of health literacy of women and men, where women had a higher mean health literacy. Besides, there was a significant difference in the mean health literacy of the students based on the academic semester, and the level of health literacy increased with the semesters. The comparison of the mean health literacy and self-care behavior in terms of other variables did not show any significant difference.
In this research, the mean comparison test was used for two independent groups of men and women. Based on Table 2 , the mean of attitude, subjective norms, and behavioral intentions differed between men and women based on the levels of health literacy. The subscales related to students’ self-care showed a significant difference between men and women based on their compliance with social distancing and vaccination. Meanwhile, the comparison of health status control behaviors, hand washing, and mask use did not show any significant difference between the two groups.
Based on Table 3 , a positive and significant correlation was found between self-care behaviors, attitude, subjective norms, perceived behavioral control, and behavioral intention.
Figure 1 displays the results of path analysis and standard coefficients. Health literacy did not have a direct and significant effect on self-care behaviors against the coronavirus. Still, its effect on subjective norms was significant, and due to the significant effect of subjective norms on behavioral intention and the significant effect of behavioral intention on self-care against the coronavirus, health literacy was a mediator variable. Moreover, attitude was the greatest predictor of behavioral intention directly; perceived behavioral control did not directly and significantly affect the students’ self-care, but its effect was mediated by behavioral intention. The fit indices of the model (Fig. 1 ) indicate the fit of the data to the model. In general, the model predicted 0.346 of the variance of the final variable, i.e., self-care against COVID-19.
Path analysis and standardized coefficients between constructs of TBP, self-care behaviors and health literacy
The findings revealed that there is a significant difference between the mean health literacy of male and female students. Women are more literate in understanding medical forms, medication usage instructions, and written information, and the level of health literacy between women and men may be different in various social strata and cultures [ 25 , 26 , 27 ]. Men make less effort to obtain information due to subjective beliefs, lower perceived sensitivity to illness, and less understanding of health threats. This difference can possibly make women more willing to report diseases compared to men [ 5 , 27 , 28 ]. Not having enough time to search for health information, especially when the disease is not quite threatening or serious, could be another reason for the low level of health literacy in men [ 29 ].
The findings of the present study demonstrated a significant difference in health literacy between the participants based on academic semesters. In general, the power of recognition and understanding to comprehend health literacy increases with the level of education. People’s problems with using different media, along with their little familiarity with medical terms, can have a negative impact on their ability to interact successfully with healthcare systems [ 25 , 30 ]. The ability to access simplified health information is another factor in improving health literacy. The use of simple images and proper examples can facilitate people’s understanding of health-related topics [ 31 , 32 ]. It is necessary for healthcare systems to modify their information services according to people’s health literacy level and provide training through simple strategies such as face-to-face counseling, group discussions, and educational pamphlets [ 23 , 33 ].
The results of this research showed a significant difference in the mean attitude score between the two groups with a low and adequate health literacy level. Positive attitudes towards self-care and adherence to correct health-related behaviors are crucial, and there is a direct relationship between health literacy and attitudes [ 34 ]. Positive attitudes and a high level of health literacy encourage patients to make appropriate decisions. When people feel that a behavior leads to a positive outcome, they adopt and maintain that behavior [ 35 ].
The difference in subjective norms scores between students with the health literacy level was another finding of this study. In diseases such as diabetes, the patient’s family can play a central role in the administration of self-care training methods. Patients whose families have adequate information about the disease and recommend correct health-related behaviors have more effective control and better compliance with treatment [ 35 , 36 ]. As a result, the formation of support groups and the participation of important people, such as the family, in self-care programs can help promote the health level of patients by strengthening the mentality of support and confirming the continuation of correct health-related behavior [ 37 , 38 , 39 ].
The findings of this research revealed a significant relationship between perceived behavioral control, health literacy level, and self-care against the coronavirus. Perceived behavioral control refers to a person’s judgment about being under control and their intentional ability to perform a specific action, which is an important factor in their performance. Perceived behavioral control is a key predictive factor in people’s intention to perform health-related behaviors and can be increased by creating a suitable environment to acquire the skills and knowledge required for behavioral control and personal empowerment [ 21 , 36 ]. People with a low level of behavioral control make less effort to perform the right health-related behaviors or change wrong behaviors [ 7 , 31 , 38 ]. Modeling, repeating in practice, simplifying, and dividing a behavior into smaller steps, as well as strategies such as goal-setting, planning action, and planning to overcome obstacles, will ultimately have a positive effect on self-care [ 40 , 41 , 42 ].
Results of the present study, like previous studies, demonstrated a significant difference between the two groups of participants with poor and adequate health literacy in terms of self-care behaviors, including social distancing and vaccination [ 26 , 43 , 44 ]. Those with low health literacy are less likely to understand written and spoken information provided by healthcare professionals and follow their instructions. These people have a worse health status, a higher rate of hospitalization, more visits to the doctor, and weaker self-care skills [ 30 , 40 , 41 ]. In general, people with a low level of health literacy often use passive communication methods, do not participate in decision-making, and face numerous problems in interacting with their physicians [ 5 , 13 , 45 ]. Therefore, healthcare professionals should empower people and patients through various trainings to improve their self-confidence, increase their participation, and help them establish effective communication with healthcare providers. In fact, self-care is based on knowledge and is influenced by people’s health-related knowledge. The higher people’s health-related knowledge, the better their ability to identify self-care needs, plan how to meet these needs, and make judgments and decisions about prioritizing their needs [ 35 , 46 ].
In the present study, the TBP theory constructs predicted 0.346 of self-care behaviors. Regression analysis in previous studies showed that 41.5% of the variance of intention and 26.2% of the variance of behavior was predicted by the constructs of TBP theory [ 47 ]. Furthermore, similar to the findings of other studies, attitude was the most important predictor of self-care behavior in students during the COVID-19 outbreak [ 8 , 26 , 35 , 46 ]. The severity and sensitivity of complications, costs, and benefits of following self-care can be a major part of the behavior variance [ 48 , 49 ].
This study investigated the mediating role of health literacy in the relationship between the TPB, and self-care behaviors against the coronavirus among the students of Abadan University of Medical Sciences. The results revealed that the health literacy of female students was higher than that of male students. The relationship of health literacy and psychological variables of attitude, subjective norms, and perceived behavioral control with self-care against COVID-19 was significant.
The present study was not possible to obtain and analyze causal relationships due to budget and time constraints. The students filled out the instruments as self-reports, and there is a possibility of bias in completing the questionnaires. The researcher’s lack of complete control over the participants and their follow-up of, especially regarding the observance of health recommendations related to the coronavirus, was the other limitation of this research. The students of a single university participated in this study, and the generalization of the results is very difficult and limited. As such, it is recommended that similar studies be conducted in other regions and for other diseases. Although the effectiveness of the TBP theory was proven in predicting and determining the factors affecting self-care behaviors during the COVID-19 outbreak, it should be noted that behavior is a multidimensional and multifactorial issue. Therefore, it is suggested that other psychological variables in the form of behavior change models and theories be used in future studies to explore and predict the relationship between self-care and health literacy.
The datasets used and analysed during the current study are available from the corresponding author on reasonable request.
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Many thanks to the students who participate in this research. The authors are grateful for the support of the AbadanUMS vice-chancellor for conducting this research.
This study was supported by Abadan University of medical sciences, Research code: 1526.
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Department of Medical Library and Information Science, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran
Sirous Panahi
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Hossein Ghalavand and Sirous Panahi developed the theoretical formalism, performed the analytic calculations and performed the numerical simulations. Both authors contributed to the final version of the manuscript.
Correspondence to Hossein Ghalavand .
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This research study was approved by Ethics Committee in Biomedical Research at Abadan University of Medical Sciences (Ethical code: IR.ABADANUMS.REC.1401.113). Every participant gave informed consent prior to taking part in the research after they were briefed on the study’s goals and advantages. Voluntary participation was encouraged. In order to protect subjects’ privacy, data collection method was conducted anonymously.
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Panahi, S., Ghalavand, H. The mediating role of health literacy in the relationship between self-care and planned behavior against Covid-19. BMC Infect Dis 24 , 608 (2024). https://doi.org/10.1186/s12879-024-09513-8
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Galdas P, Darwin Z, Fell J, et al. A systematic review and metaethnography to identify how effective, cost-effective, accessible and acceptable self-management support interventions are for men with long-term conditions (SELF-MAN). Southampton (UK): NIHR Journals Library; 2015 Aug. (Health Services and Delivery Research, No. 3.34.)
Chapter 2 quantitative review methods.
A systematic review and meta-analysis was conducted based upon a protocol published on the PROSPERO database (registration number CRD42013005394, URL: www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42013005394 ).
Deviations from the original protocol are presented in Box 1 .
Deviations from original PROSPERO protocol The target population are male adults (aged 18 years or over) living with one or more long-term conditions.
We searched the following databases using a search strategy developed in conjunction with an information specialist from the Centre for Reviews and Dissemination, University of York (see Appendix 1 ): Cochrane Database of Systematic Reviews (CDSR); Database of Abstracts of Reviews of Effects (DARE) (up to July 2013); PROSPERO (International Prospective Register of Systematic Reviews) (up to July 2013); and Medical Literature Analysis and Retrieval System Online (MEDLINE) (January 2012 to July 2013). The breadth of the literature identified meant we took a pragmatic approach and limited our search to CDSR; see Box 1 .
Randomised controlled trials (RCTs) investigating self-management support interventions in men with LTCs (identified via Cochrane systematic reviews of self-management support interventions) were included. Studies which analysed the effects of self-management support interventions in sex groups within a RCT were also identified and synthesised separately.
The following population, intervention, comparison and outcome criteria were used:
An intervention primarily designed to develop the abilities of patients to undertake management of health conditions through education, training and support to develop patient knowledge, skills or psychological and social resources.
Criteria for defining a self-management support intervention The intervention should, through some means of education, training or support, help people with a LTC by:
We piloted the screening criteria on a sample of papers before undertaking the main screening, in order to identify and resolve any inconsistencies. Screening was conducted in two phases:
For phase 1, an initial screen by title and abstract was conducted by one researcher. Two researchers then screened each article independently according to the screening criteria to identify relevant systematic reviews. Disagreements were resolved by a third researcher (principal investigator) as required.
For phase 2, each Cochrane review was screened independently for eligible RCTs by two researchers. The eligibility of each RCT was checked using the study information presented within Cochrane reviews before full papers were sourced. Full texts of each RCT were independently screened by two researchers and disagreements were resolved by a third researcher (principal investigator) as required.
For this review we focused on identifying male-only RCTs and trials which analysed the effects of interventions by sex groups. Agreement on Cochrane review eligibility was 89% and agreement on male-only RCT inclusion/exclusion and identification of RCTs containing sex group analyses was > 90%.
We designed a data extraction sheet and piloted this on a sample of papers prior to the main data extraction. Relevant data from each included article were extracted by a member of the review team and checked for completeness and accuracy by a second member of the team. Disagreements were discussed and resolved by a third person (principal investigator) as required. In instances where key information for meta-analysis was missing, efforts were made to contact authors. We extracted data on study and population characteristics, intervention details (setting, duration, frequency, individual/group, delivered by), outcome measures of health status, clinical measures, health behaviour, health-care use, self-efficacy, knowledge and understanding, communication with HCPs and items for quality assessment (Cochrane risk of bias tool 35 ). Items for economic evaluations [hospital admission, service use, health-related quality of life (HRQoL), incremental cost-effectiveness ratios] were also extracted.
Where studies were reported in multiple publications, each publication was included and relevant data were extracted.
We extracted data on the methodological quality of all included male-only RCTs and appraised this using the Cochrane risk of bias tool. Quality appraisal was undertaken by two researchers independently and disagreements were resolved through discussion. Sequence generation, allocation concealment, blinding, incomplete outcome data, selective outcome reporting and other sources of bias were assessed, assigning low, high or unclear risk of bias, as appropriate. The purpose of the quality appraisal was to describe the quality of the evidence base, not to give an inclusion/exclusion criterion.
Randomised controlled trials containing sex group analyses were assessed for quality using assessment criteria adapted from Pincus et al. 36 and Sun et al. 37 ‘Yes’, ‘No’ and ‘Unclear’ were recorded as responses to the following quality appraisal questions:
Meta-analysis was conducted using Review Manager version 5.2 (The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark).
Data were extracted, analysed and presented as standardised mean difference (SMD) to account for the different instruments used, unless otherwise stated. As a guide to the magnitude of effect, we categorised an effect size of 0.2 as representing a ‘small’ effect, 0.5 a ‘moderate’ effect and 0.8 a ‘large’ effect. 38
A random-effects model was used to combine study data. Statistical heterogeneity was assessed with the I 2 value, with ‘low’ heterogeneity set at ≤ 25%, ‘moderate’ 50% and ‘high’ 75%.
In instances where studies contained multiple intervention groups, each group was extracted and analysed independently, dividing the control group sample size to avoid double counting in the analysis.
The following outcome measures were used in the analysis where possible: HRQoL, depression, anxiety, fatigue, stress, distress, pain and self-efficacy. Where a study contained more than one measure of a particular outcome (e.g. depression measured by the Centre for Epidemiologic Studies Depression Scale 39 and Beck Depression Inventory 40 ), the tool most established in the wider literature was chosen for meta-analysis. If the tool had multiple subscales, a judgement was made about the most relevant subscale. Where studies reported at multiple time periods, outcome measures reported at or closest to 6 months were used, as measures around this time were by far the most frequently reported.
Unless otherwise specified in the results section, positive effect sizes indicate beneficial outcomes for HRQoL and self-efficacy outcomes, while negative effect sizes indicate beneficial outcomes for depression, anxiety, fatigue, stress, distress and pain outcomes.
We conducted four types of analysis, described below.
Analysis 1 sought to determine whether studies in males show larger, similar or smaller effects than studies in females and mixed-sex groups within interventions included within the ‘parent’ Cochrane review. We screened all included Cochrane reviews of self-management support interventions to identify those that contained analysis on outcomes of interest and at least two relevant male-only RCTs. Where an eligible review was identified that met these criteria, the studies were categorised as male only, mixed sex and female only ( Figure 1 ).
Analysis 1: ‘within-Cochrane review analysis’.
Such comparisons across trials do not have the protection of randomisation, and there may be differences between the studies included in each sex group which account for differences in effects between groups. We presented data on the comparability of these trials within these three categories, including the age of the included patient populations, and on the quality of the studies (using allocation concealment as an indicator of quality).
We report the effect size [together with significance and 95% confidence interval (CI)] of self-management support in each sex group (male only, mixed sex, female only). We conducted analyses to test whether or not interventions showed significantly different effects in sex groups. It should be noted that the power to detect significant differences in such analyses can be limited.
Analysis 2 sought to determine whether studies in males show larger, similar or smaller effects than studies in females and mixed-sex groups within types of self-management support pooled across reviews.
In analysis 2, data were pooled according to broad intervention type across reviews, rather than within individual reviews as in analysis 1 ( Figure 2 ). This allowed us to determine whether broad types/components of self-management support interventions show larger, similar or smaller effects in males than in females and mixed populations. Limitations in the data meant that we were able to conduct analyses on only physical activity, education, peer support, and HCP monitoring and feedback interventions.
Analysis 2: ‘across-Cochrane review analysis’.
We report the effect size (together with significance and 95% CI) of self-management support in each sex group (male only, mixed sex, female only). We conducted analyses to test whether or not interventions showed significantly different effects in sex groups. It should be noted that the power to detect significant differences in such analyses can be limited.
We conducted a meta-analysis on trials including males only, according to broad intervention type – physical activity, education, peer support, and HCP monitoring and feedback – and compared effects between intervention types ( Figure 3 ). This allowed us to determine whether or not certain broad categories of self-management support intervention were effective in men.
Analysis 3: ‘male-only intervention type analyses’.
We identified RCTs which analysed the effects of self-management support interventions in sex groups. We sought to extract relevant data on the direction and size of moderating effects in secondary analysis (i.e. whether males show larger, similar or smaller effects than females), and assess these effects in the context of relevant design data, such as sample size, and the quality of the secondary analysis ( Figure 4 ).
Analysis 4: ‘within-trial sex group analysis’.
Sex group analyses within trials do in theory provide greater comparability in terms of patient and intervention characteristics than analyses 1–3.
A mixture of LTCs was included within each analysis, constituting the main analysis. Although this was not in the original protocol, we attempted to conduct an analysis by each disease area. We found there were sufficient data to conduct a sex-comparative analysis in only cancer studies; the results are presented in Appendix 2 .
The plan to use the behavioural change techniques (BCT) taxonomy was dropped (see Box 1 on protocol deviations). Post hoc, we took a pragmatic approach to coding interventions. Development of the intervention categories was informed by the published literature identified in this project and previous work conducted by the PRISMS and RECURSIVE project teams. 7 , 33 Table 1 provides a list of the categories and their associated description. Categories were designed to be broadly representative of the interventions identified and facilitate comparison of intervention types in the analysis. Two members of the review team independently assessed the ‘type’ of self-management support intervention in each study in order to categorise it, and disagreements were identified and resolved by discussion with a team member.
Self-management support intervention categories and description
The review of cost-effectiveness studies was initially planned as a two-stage review. First, we would review economic evaluations of self-management interventions on males only. Subsequently, we would review all economic evaluations with group analyses in which the costs and effects for males and females could be separated.
Study quality was assessed using a modified version of the Drummond checklist where appropriate. 45
We identified a total of 40 RCTs on self-management support interventions conducted in male-only samples (some trials have more than one reference) ( Figure 5 ). The majority of the studies were conducted in the USA ( n = 23), 46 – 70 with the remainder conducted in the UK ( n = 6), 71 – 78 Canada ( n = 5), 79 – 83 Spain ( n = 3), 84 – 88 Sweden ( n = 1), 89 Poland ( n = 1) 90 and Greece ( n = 1). 91 Males with prostate cancer were the most frequently studied male-only population ( n = 15) included in this review. 48 , 49 , 52 , 58 , 59 , 61 , 64 – 66 , 68 , 69 , 72 , 78 , 80 , 89 Other disease areas included hypertension ( n = 6), 47 , 71 , 79 , 82 , 83 , 85 , 86 COPD ( n = 6), 54 , 55 , 73 – 76 , 81 , 84 , 87 , 88 heart failure ( n = 4), 62 , 67 , 90 , 91 type 2 diabetes ( n = 3), 46 , 50 , 51 , 70 diabetes of unspecified type ( n = 1), 56 arthritis ( n = 1) 63 and testicular cancer ( n = 1). 77 One multimorbidity study recruited obese men with type 2 diabetes and chronic kidney disease. 57 The age of participants ranged from 25 to 89 years and, where reported, ethnicity was predominantly white. Only one study reported socioeconomic status using a validated tool; 63 the majority of other publications included a description of education or annual income.
Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram for the quantitative review.
A total of 51 distinct self-management support interventions were reported across the 40 included male-only studies. Physical activity ( n = 16), 49 , 57 , 62 , 72 – 76 , 78 , 80 , 81 , 84 , 87 – 91 education ( n = 36), 46 – 55 , 58 – 61 , 63 – 67 , 70 – 72 , 77 , 79 – 81 , 83 – 88 peer support ( n = 17) 47 , 49 , 53 , 56 , 68 – 72 , 80 and HCP monitoring and feedback ( n = 25) 46 , 47 , 50 – 52 , 56 , 57 , 60 , 61 , 66 – 68 , 70 , 71 , 75 , 76 , 78 – 80 , 82 – 89 were the most frequently reported components of these interventions. Three interventions with a psychological component, 64 , 77 two interventions containing a financial incentive component 82 , 83 and one study containing an action plan component 19 were also identified.
Twenty-three of the interventions were aimed at individuals, 46 , 48 , 50 – 52 , 54 , 55 , 60 , 61 , 64 , 65 , 67 – 69 , 75 – 78 , 82 – 86 20 were aimed at groups 47 , 53 , 58 , 59 , 62 , 66 , 70 , 71 , 79 , 89 – 91 and the remainder used a mixed individual and group approach ( n = 6). 49 , 56 , 72 – 74 , 80 , 81 , 87 , 88 It was unclear what approach was used in two studies. 57 , 63 Over half of the interventions lasted 0–5 months ( n = 28), 47 , 53 , 58 – 64 , 67 – 69 , 71 – 80 , 85 , 86 12 interventions ranged between 6 and 11 months, 46 , 52 , 54 – 57 , 66 , 70 , 84 , 90 , 91 six interventions were 12 months or longer 49 , 65 , 81 , 82 , 84 , 87 , 88 and in five cases the total programme duration was unclear. 48 , 83 , 89
The mode of administration of the interventions varied. They included telephone-based support ( n = 6), 60 , 61 , 65 , 67 face-to-face delivery ( n = 21), 47 , 53 – 55 , 58 , 59 , 62 – 64 , 66 , 68 – 70 , 77 , 83 , 89 – 91 remote unsupervised activities ( n = 2), 75 , 76 , 78 a combination of face-to-face delivery and remote unsupervised activities ( n = 20), 46 – 51 , 57 , 71 – 74 , 79 – 82 , 84 – 89 and a combination of face-to-face delivery and telephone support ( n = 2). 52 , 56
In terms of setting, interventions were reported to be home-based ( n = 11), 46 , 52 , 60 , 61 , 65 , 67 , 75 , 76 , 78 at a non-home location such as a dedicated gym, pharmacy, hospital clinic, work, university laboratory, coffee shop or other community-based venue ( n = 12), 53 – 55 , 62 – 64 , 68 – 70 , 77 , 85 , 86 , 90 a combination of home and non-home-based venue ( n = 14) 48 – 51 , 56 , 57 , 72 – 74 , 79 – 84 , 87 , 88 or not clearly reported in the publication ( n = 14). 47 , 58 , 59 , 66 , 71 , 89 , 91
Half of the studies 79 – 82 , 46 , 48 – 51 , 53 , 56 , 58 , 59 , 66 , 70 , 72 , 78 , 84 , 87 , 88 reported on some aspect of compliance with the self-management intervention and most participants were followed up for 6 months or less ( n = 24) following participation in the intervention.
Table 2 provides an overview of study details and Table 3 includes detailed descriptions of the self-management support intervention.
Male-only study characteristics
Male-only studies: self-management support intervention characteristics
Study quality was assessed using the Cochrane risk of bias tool, 92 which covers six key domains: sequence generation, allocation concealment, blinding performance, incomplete outcome data, selective outcome reporting and other sources of bias.
Studies were often poorly reported, making judgements of quality difficult. With the exception of selective outcome reporting, the most frequent rating for all domains was an unclear risk of bias. For the selective outcome-reporting domain, a low risk of bias was most frequently reported assignment. Table 4 describes the risk of bias allocation for each study by each domain. Figure 6 presents a summary of the male-only study quality assessment findings.
Male-only study Cochrane risk of bias findings
Summary of male-only study Cochrane risk of bias findings.
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Enhancing risk management in road infrastructure facing flash floods through epistemological approaches.
2. literature review, 2.1. uncertainty in risk management, 2.2. theoretical approach in risk management and risk assessment, 2.3. flood risk assessment, 2.4. pavement failure risk assessment, 3. materials and methods, 3.1. integrative approach to addressing uncertainty, 3.2. case study, 4.1. rainfall analysis, 4.2. analysis of underlying causes and response strategies, 5. discussion, 6. conclusions, author contributions, data availability statement, conflicts of interest.
Click here to enlarge figure
Likelihood | Impact | ||||
---|---|---|---|---|---|
Minor | Moderate | Major | Severe | Catastrophic | |
Rare | Low | Low | Low | Low | Low |
Unlikely | Low | Low | Medium | Medium | Medium |
Possible | Low | Medium | Medium | High | High |
Likely | Low | Medium | High | High | Extreme |
Almost Certain | Low | Medium | High | Extreme | Extreme |
Concept | IRI (m/km) | PCI |
---|---|---|
Excellent | 1.0–1.9 | 5–4 |
Good | 1.9–2.7 | 4–3 |
Regular | 2.7–3.5 | 3–2 |
Poor | 3.5–4.6 | 2–1 |
Very Poor | >4.6 | 1–0 |
Aspect | Question |
---|---|
Risk Identification | What methods have been used to identify risks related to flash floods? |
Have previous experiences and expert knowledge on flash floods been considered in identifying risks? | |
Have all potential sources of risk, including those internal and external to the road infrastructure project, been explored? | |
Risk Analysis | How have the identified risks from flash floods been quantified or qualified? |
Have flash flood risks been assessed based on their likelihood of occurrence and potential impact? | |
Have contextual and cultural factors, particularly those related to flash flood-prone areas, been considered in the risk analysis? | |
Risk Response Planning | Have mitigation, transfer, acceptance, or avoidance strategies been developed for the identified flash flood risks? |
How will response strategies adapt if flash flood conditions or the environment change? | |
Risk Monitoring and Control | What mechanisms are in place to monitor flash flood risks throughout the road infrastructure project? |
How will the risk management plan be updated in the face of new knowledge or changes in flash flood conditions? | |
Sustainability Assessment | How do the planned risk mitigation strategies for flash floods impact environmental sustainability? |
What measures are in place to ensure that sustainability goals (such as reduced carbon footprint, minimal waste, etc.) are not compromised in the face of flash flood risks? | |
Epistemological Reflection | Are there assumptions or biases that might have influenced flash flood risk identification and analysis? |
Has an environment been fostered that allows for questioning and critically reviewing the assumptions underlying flash flood risk management? | |
How do you incorporate new knowledge or technological advances into the management of flash flood risks in road infrastructure projects? | |
How do you critically assess the validity and reliability of information used in managing flash flood risks? |
Date | Section (km) | Municipality | Longitude | Latitude |
---|---|---|---|---|
09/04/2010 | 617 | Salvador | −38.438097 | −12.886053 |
14/04/2010 | 616 | Salvador | −38.432163 | −12.879618 |
23/08/2011 | 615 | Feira de Santana | −38.427477 | −12.872084 |
09/11/2011 | 622 | Salvador | −38.464935 | −12.918797 |
09/11/2011 | 624 | Salvador | −38.471872 | −12.933742 |
09/11/2011 | 614 | Salvador | −38.423701 | −12.863979 |
19/12/2014 | 416 | Nova Fátima | −39.550888 | −11.681749 |
19/12/2014 | 410 | Nova Fátima | −39.591691 | −11.643446 |
04/01/2016 | 622 | Salvador | −38.464935 | −12.9188 |
04/01/2016 | 625 | Salvador | −38.470833 | −12.94188 |
22/01/2016 | 438.9 | Riachão do Jacuípe | −39.38542 | −11.81236 |
Municipality | K | a | b | c |
---|---|---|---|---|
Salvador | 1288.500 | 0.200 | 22.000 | 0.810 |
Feira de Santana | 5853.367 | 0.212 | 51.823 | 1.021 |
Nova Fátima | 8614.915 | 0.241 | 55.485 | 1.107 |
Riachão do Jacuípe | 8263.036 | 0.237 | 55.035 | 1.096 |
Date | Section (km) | Municipality | Precipitation Accumulated Day (mm) | Total Accumulated in the Month (mm) |
---|---|---|---|---|
09/04/2010 | 617 | Salvador | 339.81 | 1090.81 |
14/04/2010 | 616 | Salvador | 102.10 | |
23/08/2011 | 615 | Feira de Santana | 73.81 | 307.92 |
09/11/2011 | 614–622–624 | Salvador | 74.75 | 400.22 |
19/12/2014 | 410–416 | Nova Fátima | 195.00 | 4706.85 |
04/01/2016 | 622–625 | Salvador | 245.37 | 745.99 |
22/01/2016 | 438.9 | Riachão do Jacuípe | 74.29 |
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Ariza Flores, V.A.; de Sousa, F.O.; Oda, S. Enhancing Risk Management in Road Infrastructure Facing Flash Floods through Epistemological Approaches. Buildings 2024 , 14 , 1931. https://doi.org/10.3390/buildings14071931
Ariza Flores VA, de Sousa FO, Oda S. Enhancing Risk Management in Road Infrastructure Facing Flash Floods through Epistemological Approaches. Buildings . 2024; 14(7):1931. https://doi.org/10.3390/buildings14071931
Ariza Flores, Victor Andre, Fernanda Oliveira de Sousa, and Sandra Oda. 2024. "Enhancing Risk Management in Road Infrastructure Facing Flash Floods through Epistemological Approaches" Buildings 14, no. 7: 1931. https://doi.org/10.3390/buildings14071931
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There is a growing literature exploring the placebo response within specific mental disorders, but no overarching quantitative synthesis of this research has analyzed evidence across mental disorders. We carried out an umbrella review of meta-analyses of randomized controlled trials (RCTs) of biological treatments (pharmacotherapy or neurostimulation) for mental disorders. We explored whether placebo effect size differs across distinct disorders, and the correlates of increased placebo effects. Based on a pre-registered protocol, we searched Medline, PsycInfo, EMBASE, and Web of Knowledge up to 23.10.2022 for systematic reviews and/or meta-analyses reporting placebo effect sizes in psychopharmacological or neurostimulation RCTs. Twenty meta-analyses, summarising 1,691 RCTs involving 261,730 patients, were included. Placebo effect size varied, and was large in alcohol use disorder ( g = 0.90, 95% CI [0.70, 1.09]), depression ( g = 1.10, 95% CI [1.06, 1.15]), restless legs syndrome ( g = 1.41, 95% CI [1.25, 1.56]), and generalized anxiety disorder ( d = 1.85, 95% CI [1.61, 2.09]). Placebo effect size was small-to-medium in obsessive-compulsive disorder ( d = 0.32, 95% CI [0.22, 0.41]), primary insomnia ( g = 0.35, 95% CI [0.28, 0.42]), and schizophrenia spectrum disorders (standardized mean change = 0.33, 95% CI [0.22, 0.44]). Correlates of larger placebo response in multiple mental disorders included later publication year (opposite finding for ADHD), younger age, more trial sites, larger sample size, increased baseline severity, and larger active treatment effect size. Most (18 of 20) meta-analyses were judged ‘low’ quality as per AMSTAR-2. Placebo effect sizes varied substantially across mental disorders. Future research should explore the sources of this variation. We identified important gaps in the literature, with no eligible systematic reviews/meta-analyses of placebo response in stress-related disorders, eating disorders, behavioural addictions, or bipolar mania.
Introduction.
A placebo is an ‘inactive’ substance or ‘sham’ technique that is used as a control for assessing the efficacy of an active treatment [ 1 ]. However, study participants in a placebo control group may experience considerable symptom improvements - a ‘placebo response’ [ 1 , 2 , 3 ]. Statistical artifacts or non-specific effects account for some of the placebo response. For example, many individuals seek treatment and are enrolled in clinical trials while their symptoms are at their worst. Their symptoms will gradually return to their usual severity (‘regression to the mean’), giving the appearance of a placebo response [ 4 ]. Further, it has been suggested that the placebo response is exacerbated due to unreliable ratings as well as baseline symptom severity inflation if raters are aware of severity criteria for entry to a trial [ 5 , 6 ]. Other potential sources of apparent placebo responses include sampling biases caused by the withdrawal of the least improved patients in the placebo arm, non-specific beneficial effects resulting from interactions with staff delivering the trial, environmental effects due to inpatient care during placebo-controlled trials, or other unaccounted for factors, such as dietary or exercise changes during the trial [ 7 , 8 , 9 ]. Nonetheless, there is evidence that placebo administration results in ‘true’ - or non-artefactual - placebo effects, that is, identifiable changes in biological systems [ 1 , 10 , 11 ]. For example, placebo administration is capable of causing immunosuppression [ 12 , 13 ], placebo effects in Parkinson’s disease are driven by striatal dopamine release [ 10 , 14 ], and placebo analgesia is mediated by endogenous opioid release [ 15 , 16 ]. Furthermore, there is evidence that placebo effects in depressive and anxiety disorders are correlated with altered activity in the ventral striatum, orbitofrontal cortex, rostral anterior cingulate cortex, and the default mode network [ 17 ]. The placebo effect size can be increased through the use of verbal suggestions and conditioning procedures, thus suggesting the underlying role of psychological mechanisms including learning and expectations [ 11 , 18 ].
Across age groups, treatment modalities, and diverse mental disorders, biological treatments (pharmacotherapy or neurostimulation) do reduce symptoms [ 19 , 20 , 21 , 22 ], but only a subgroup of patients experience a clinically significant symptom response or enter remission [ 23 , 24 , 25 ]. Furthermore, current medications may also have unfavourable side effects [ 23 , 26 , 27 , 28 , 29 , 30 , 31 ]. Given the high prevalence of mental disorders and their significant socioeconomic burden [ 32 , 33 , 34 ], there is a need to develop more effective and safer psychopharmacologic and neurostimulation treatments. However, in randomized-controlled trials (RCTs), the magnitude of the placebo response may be considerable, which can affect the interpretation of their results [ 35 , 36 , 37 ]. For example, in antipsychotic trials over the past 40 years, placebo response has increased while medication response has remained consistent [ 38 , 39 ]. Consequently, the trial’s ability to statistically differentiate between an active medication and a placebo is diminished [ 40 ]. Indeed, large placebo response rates have been implicated in hindering psychotropic drug development [ 41 , 42 ]. The increased placebo response can also affect larger data synthesis approaches, such as network meta-analysis, in which assumptions about placebo responses (e.g. stability over time) might affect the validity of results [ 43 ].
Improved understanding of participant, trial, and mental disorder-related factors that contribute to placebo response might allow better clinical trial design to separate active treatment from placebo effects. There is a growing body of research, including individual studies and systematic reviews/meta-analyses, examining the placebo response within specific mental disorders [ 35 ]. However, to date, no overarching synthesis of this literature, to detect any similarities or differences across mental disorders, has been published. We therefore carried out an umbrella review of meta-analyses to address this need. We aimed to assess the placebo effect size in RCTs for a range of mental disorders, whether the effect size differs across distinct mental disorders, and identify any correlates of increased placebo effect size or response rate.
The protocol for this systematic umbrella review was pre-registered on the open science framework ( https://osf.io/fxvn4/ ) and published [ 44 ]. Deviations from this protocol, and additions to it, were: eight authors were involved in record screening rather than two; we reported effect sizes pooled across age groups and analyses comparing placebo effect sizes between age groups; and we included a meta-analysis that incorporated trials of dietary supplements as well as medications in autism. For the rationale behind these decisions, see eMethods.
Eight authors (NH, AB, VB, LE, OKF, LM, CR, SS) carried out the systematic review and data extraction independently in pairs. Discrepancies were resolved through consensus or through arbitration by a third reviewer (NH or SCo). We searched, without date or language restrictions, up to 23.10.2022, Medline, PsycInfo, EMBASE + EMBASE Classic, and Web of Knowledge for systematic reviews with or without meta-analyses of RCTs of biological treatments (psychopharmacotherapy or neurostimulation) compared with a placebo or sham treatment in individuals with mental disorders diagnosed according to standardized criteria. The full search strategy is included in eMethods. We also sought systematic reviews of RCTs conducted in patients with sleep-wake disorders, since these disorders are included in the DSM-5 and their core symptoms overlap with those of mental disorders [ 45 ]. We retained systematic reviews with or without meta-analyses that reported within-group changes in symptoms in the placebo arm.
Next, to prevent duplication of data, a matrix containing all eligible systematic reviews/meta-analyses for each category of mental disorder was created. Where there were multiple eligible systematic reviews/meta-analyses for the same disorder and treatment, we preferentially included meta-analyses, and if multiple eligible meta-analyses remained, then we included the one containing the largest number of studies for the same disorder and treatment, in line with recent umbrella reviews [ 46 , 47 ].
Data were extracted by at least two among six reviewers (AB, VB, LE, OKF, CR, SS) independently in pairs via a piloted form. All extracted data were further checked by a third reviewer (NH). See eMethods for a list of extracted data.
Our primary outcome was the pre-post effect size of the placebo/sham related to the condition-specific primary symptom change for each mental disorder. Secondary outcomes included any other reported clinical outcomes in eligible reviews. We report effect sizes calculated within-group from baseline and post-treatment means by meta-analysis authors, including Cohen’s d and Hedges’ g for repeated measures, which account for both mean difference and correlation between paired observations; and standardized mean change, where the average change score is divided by standard deviation of the change scores. We interpreted the effect size in line with the suggestion by Cohen [ 48 ], i.e. small (~0.2), medium (~0.5), or large (~0.8).
In addition, we extracted data regarding potential correlates of increased placebo effect size or response rate (as defined and assessed by the authors of each meta-analysis) in each mental disorder identified through correlation analyses or meta-regression. Where available, results from multivariate analyses were preferred.
The methodological quality of included reviews was assessed by at least two among six reviewers (AB, VB, LE, OKF, NH, CR) independently and in pairs using the AMSTAR-2 tool, a critical appraisal tool that enables reproducible assessments of the conduct of systematic reviews [ 49 ]. The methodological quality of each included review was rated as high, moderate, low, or critically low.
Our initial search identified 6,108 records. After screening titles and abstracts, we obtained and assessed 115 full-text reports (see eResults for a list of articles excluded following full-text assessment, with reasons). Of these, 20 were deemed eligible, and all were systematic reviews with meta-analysis (Fig. 1 ). In total, the 20 included meta-analyses synthesized data from 1,691 RCTs (median 55) involving 261,730 patients (median 5,365). These meta-analyses were published between 2007 and 2022 and involved individuals with the following mental disorders: major depressive disorder (MDD; n = 6) [ 50 , 51 , 52 , 53 , 54 , 55 ], anxiety disorders ( n = 4) [ 55 , 56 , 57 , 58 ], schizophrenia spectrum disorders ( n = 3) [ 38 , 59 , 60 ], alcohol use disorder (AUD; n = 1) [ 61 ], attention-deficit/hyperactivity disorder (ADHD; n = 1) [ 62 ], autism spectrum disorders ( n = 1) [ 63 ], bipolar depression ( n = 1) [ 64 ], intellectual disability ( n = 1) [ 65 ], obsessive-compulsive disorder (OCD; n = 1) [ 66 ], primary insomnia ( n = 1) [ 67 ], and restless legs syndrome (RLS; n = 1) [ 68 ].
Twenty meta-analyses were included.
The methodological quality of the included meta-analyses according to AMSTAR-2 ratings was high in two meta-analyses (ADHD and autism), low in four meta-analyses, and critically low in the remaining 14 meta-analyses (Table 1 ). The most common sources of bias that led to downgrading on the AMSTAR-2 were: no list of excluded full-text articles with reasons ( k = 14), no explicit statement that the protocol was pre-registered ( k = 14), and no assessment of the potential impact of risk of bias in individual studies on the results ( k = 13). The full reasoning behind our AMSTAR-2 ratings is included in eResults.
Our first objective was to determine placebo effect sizes across mental conditions. Data regarding within-group placebo efficacy were reported in sixteen of the included meta-analyses [ 38 , 50 , 52 , 53 , 55 , 56 , 57 , 58 , 60 , 61 , 62 , 63 , 65 , 66 , 67 , 68 ]. Placebo effect sizes for the primary outcomes ranged from 0.23 to 1.85, with a median of 0.64 (Fig. 2 ). Median heterogeneity across meta-analyses was I 2 = 72%, suggesting a generally high percentage of heterogeneity due to true variation across studies.
Dots represent placebo group effect size while triangles represent active effect size. CI confidence interval, MDD major depressive disorder, GAD generalized anxiety disorder, SAD social anxiety disorder, OCD obsessive-compulsive disorder, g Hedges’ g, d Cohen’s d, SMC standardized mean change, NR not reported.
A detailed description of each meta-analysis included for this objective is included in eResults. Here, we report a summary of these results in order of the greatest number of RCT’s and meta-analyses included per disorder. In MDD, a large within-group placebo effect was observed ( g = 1.10, 95% CI [1.06, 1.15]), although active medication had an even larger effect size ( g = 1.49, 95% CI [1.44, 1.53]) [ 50 ]. Similarly, in children and adolescents with MDD, placebo effect size was large ( g = 1.57, 95% CI [1.36, 1.78]), as was serotonergic medication effect size ( g = 1.85, 95% CI [1.70, 2.00]) [ 55 ]. In treatment-resistant MDD, the within-group placebo effect size was smaller than in non-treatment-resistant MDD ( g = 0.89, 95% CI [0.81, 0.98]) [ 52 ]. In neuromodulation trials for MDD, the effect size of sham was g = 0.80 (95% CI [0.65, 0.95]) [ 53 ]. In this meta-analysis, the effect size was larger for non-treatment-resistant ( g = 1.28, 95% CI [0.47, 2.97]) compared to treatment-resistant participants (g = 0.50 95% CI [0.03, 0.99]) [ 53 ]. In adults with anxiety disorders, placebo effect sizes varied across disorders, with a medium effect size in panic disorder ( d = 0.57, 95% CI [0.50, 0.64]) [ 56 ] and large effect sizes in generalized anxiety disorder (GAD) ( d = 1.85, 95% CI [1.61, 2.09]) and social anxiety disorder (SAD) ( d = 0.94, 95% CI [0.77, 1.12]) [ 57 ]. Other meta-analyses in children and adolescents and older adults pooled RCTs across anxiety disorders, and found large placebo effect sizes ( g = 1.03, 95% CI [0.84, 1.21] and d = 1.06, 95% CI [0.71, 1.42], respectively) [ 55 , 58 ]. In ADHD, placebo effect size was medium-to-large for clinician-rated outcomes (SMC = 0.75, 95% CI [0.67, 0.83]) [ 62 ]. There was additionally a significant negative relationship between placebo effect size and drug-placebo difference (−0.56, p < 0.01) for self-rated outcomes [ 62 ]. In schizophrenia spectrum disorders, placebo effect size was small-to-medium in antipsychotic RCTs (SMC = 0.33, 95% CI [0.22, 0.44]) [ 38 ] and medium in RCTs focusing specifically on negative symptoms ( d = 0.64, 95% CI [0.46, 0.83]) [ 60 ]. Placebo effect size in RLS was large when measured via rating scales ( g = 1.41, 95% CI [1.25, 1.56]), but small ( g = 0.02 to 0.24) in RCTs using objective outcomes [ 68 ]. In autism, placebo effect sizes were small (SMC ranged 0.23 to 0.36) [ 63 ]. Similarly, placebo effect size was small in OCD ( d = 0.32, 95% CI [0.22, 0.41]), although larger in children and adolescents ( d = 0.45, 95% CI [0.35, 0.56]) compared with adults ( d = 0.27, 95% CI [0.15, 0.38]) [ 66 ]. Placebo effect size was large in AUD ( g = 0.90, 95% CI [0.70, 1.09]) [ 61 ], small in primary insomnia ( g ranged 0.25 to 0.43) [ 67 ], and medium in intellectual disability related to genetic causes ( g = 0.47, 95% CI [0.18, 0.76]) [ 65 ].
Our second objective was to examine the correlates of increased placebo response. We included 14 meta-analyses that reported correlates of placebo effect size or response rate through correlation analysis or meta-regression [ 38 , 51 , 53 , 54 , 56 , 57 , 59 , 60 , 61 , 62 , 63 , 64 , 66 , 68 ]. The key correlates extracted from these studies are summarized in Table 2 .
Several variables were consistently identified across meta-analyses. Increased number of trial sites was a positive correlate of increased placebo response in MDD [ 51 , 54 ], schizophrenia spectrum disorders [ 59 ], and autism spectrum disorders [ 63 ]. Similarly, increased sample size was positively associated with placebo effect size in schizophrenia spectrum disorders [ 59 ], OCD [ 66 ], and panic disorder [ 56 ]. Later publication or study year was associated with greater placebo response in anxiety disorders [ 56 , 57 ], schizophrenia spectrum disorders [ 38 ], AUD [ 61 ], and OCD [ 66 ] but not in MDD [ 51 ], and with reduced placebo response in ADHD [ 62 ]. Younger age was associated with increased placebo responses in schizophrenia spectrum disorders [ 38 , 59 ] and OCD [ 66 ]. Increased baseline illness severity was associated with increased placebo response in schizophrenia spectrum disorders [ 38 ], ADHD [ 62 ], and AUD [ 61 ]. Increased trial or follow-up duration was positively associated with increased placebo response in MDD [ 51 ], but negatively associated with placebo response in schizophrenia spectrum disorders [ 38 , 60 ] and OCD [ 66 ]. Finally, the effect size of active treatment was positively associated with increased placebo response in neurostimulation trials for MDD [ 53 ], bipolar depression [ 64 ], autistic spectrum disorders [ 63 ], and ADHD [ 62 ].
There were also some variables associated with increased placebo response in single disorders only. Flexible dosing, rather than fixed dosing, was associated with increased placebo response in MDD [ 51 ]. Increased illness duration was associated with reduced placebo response in schizophrenia spectrum disorders [ 38 ]. In RCTs for negative symptoms of schizophrenia, a higher number of active treatment arms was associated with increased placebo response [ 60 ]. A number of treatment administrations was a positive correlate of increased placebo response in patients with AUD [ 61 ]. A low risk of bias in selective reporting was associated with increased placebo response in ADHD [ 62 ]. Finally, a low risk of bias in allocation concealment was associated with increased placebo response in autism [ 63 ].
To our knowledge, this is the first overarching synthesis of the literature exploring the placebo response in RCTs of biological treatments across a broad range of mental disorders. We found that placebo responses were present and detectable across mental disorders. Further, the placebo effect size across these disorders varied between small and large (see Fig. 3 ). Additionally, several variables appeared to be associated with increased placebo effect size or response rate across a number of disorders, while others were reported for individual disorders only.
CI confidence interval, MDD major depressive disorder, GAD generalized anxiety disorder, SAD social anxiety disorder, OCD obsessive-compulsive disorder, g Hedges’ g, d Cohen’s d, SMC standardized mean change.
Our umbrella review distinguishes itself from a recent publication on placebo mechanisms across medical conditions [ 69 ]. Only four systematic reviews of research in mental disorders were included in that recent review [ 69 ], none of which were eligible for inclusion in our umbrella review, as we focus specifically on RCTs in mental disorders. Thus, our current umbrella review synthesizes different literature and is complementary [ 69 ].
We found substantial variation in placebo effect sizes across mental disorders. In GAD, SAD, MDD, AUD, and RLS (for subjective outcomes), placebo effects were large (>0.9), while they were small (approximately 0.3) in OCD, primary insomnia, autism, RLS (for objective outcomes), and schizophrenia spectrum disorders. It is noteworthy that placebo effect size/response rate correlated with active treatment effect size/response rate in many disorders (MDD, bipolar depression, ADHD, and autism). Nonetheless, where reported, active treatment was always superior. This possibly suggests an underlying ‘treatment responsiveness’ of these disorders that can vary in size. Perhaps, the natural history of a disorder is an important factor in ‘responsiveness’, i.e., disorders in which there is greater natural fluctuation in severity will show larger placebo (and active treatment) effect sizes. Supporting this hypothesis, increased trial duration predicted a larger placebo effect size in MDD, a disorder in which the natural course includes improvement [ 31 , 51 , 70 ]. Conversely, in schizophrenia spectrum disorders where improvement (particularly of negative symptoms) is less likely [ 71 ], increased trial and illness duration predicted a smaller placebo effect size [ 38 , 60 ]. However, previous meta-analyses suggest that natural improvement, for example, measured via waiting list control, does not fully account for the placebo effect in depression and anxiety disorders [ 72 , 73 ]. Statistical artifact, therefore, does not seem to fully explain the variation in effect size.
Non-specific treatment mechanisms are likely an additional source of the observed placebo effect. For example, those with treatment-resistant illness might have reduced expectations regarding treatment. This assumption is supported by the subgroup analysis reported by Razza and colleagues showing sham neuromodulation efficacy reduced as the number of previous failed antidepressant trials increased [ 53 ]. Another factor to consider is the outcome measure chosen. For example, the placebo effect size in panic disorder was smaller when calculated with objective or self-report measures compared with clinician-rated measures [ 56 ]. A similar finding was reported in ADHD trials [ 62 ]. Why placebo effect sizes would differ with clinician-rated versus self-rated scales is unclear. This might result from ‘demand characteristics’ (i.e., cues that suggest to a patient how they ‘should’ respond), or unblinding of the rater, or a combination of the two [ 74 , 75 ].
Several correlates of increased placebo response were reported in included meta-analyses. These included a larger sample size, more study sites, a later publication year (but with an opposite finding for ADHD), younger age, and increased baseline illness severity. This might reflect changes in clinical trial methods over time, the potential for increased ‘noise’ in the data with larger samples or more study sites, and, more speculatively, variables associated with increased volatility in symptoms [ 39 , 51 , 76 ]. A more extensive discussion regarding the potential reasons these variables might correlate with, or predict, placebo response is included in the eDiscussion. Although some correlates of increased placebo response were identified, perhaps more pertinently, it is unknown whether these also predict the separation between active treatment and placebo in most mental disorders. Three included meta-analyses did show that as placebo response increases, the likelihood of drug-placebo separation decreases [ 38 , 62 , 64 ]. This suggests correlates of placebo effect size are also correlates of trial success or failure, but this hypothesis needs explicit testing. In addition, few of the meta-analyses we included explored whether correlates of placebo response differed from correlates of active treatment response. For example, in clinical trials for gambling disorder, response to active treatment was predicted by weeks spent in the trial and by baseline severity, while response to placebo was predicted by baseline depressive and anxiety symptoms [ 77 ]. Furthermore, there is evidence that industry sponsorship is a specific correlate of reduced drug-placebo separation in schizophrenia spectrum disorders [ 78 ]. The largest meta-analysis that we included (conducted by Scott et al. [ 50 ]) did not explore correlates of increased placebo response through meta-regression analysis; rather, it was designed specifically to assess the impact of the use of placebo run-in periods in antidepressant trials. The authors found that use of a placebo run-in was associated with reduced placebo response. However, this effect did not enhance sensitivity to detect medication efficacy versus control groups, as trials with placebo run-in periods were also associated with a reduced medication response. Similar effects of placebo run-in were seen in univariate (but not multivariable) models in ADHD, where placebo run-in reduced placebo effect size in youth, but did not affect drug vs placebo difference [ 62 ]. Further work should be undertaken to ascertain whether trial-level correlates (including the use of placebo run-in) differentially explain active treatment or placebo response and whether controlling for these can improve drug-placebo separation.
Our results should be considered in the light of several possible limitations. First, as in any umbrella review, we were limited by the quality of the meta-analyses we included. Our AMSTAR-2 ratings suggest that confidence in the conclusions of most included meta-analyses should be critically low or low. Indeed, several meta-analyses did not assess for publication bias or for bias in included RCTs. This is relevant, as the risk of bias in selective reporting was highlighted as potentially being associated with placebo effect size in ADHD [ 62 ], and might therefore be relevant in other mental disorders. Second, our results are potentially vulnerable to biases or unmeasured confounders present in the included meta-analyses. Third, we attempted to prevent overlap and duplication of information by including only the meta-analyses with the most information. This might, however, have resulted in some data not being included in our synthesis. Fourth, an exploration of the potential clinical relevance of the placebo effect sizes reported here was outside the scope of the current review but should be considered an important question for future research. Finally, the meta-analyses we included encompassed RCTs with different levels of blinding (double-blind, single-blind). Although the majority of trials were likely double-blind, it is possible that different levels of blinding could have influenced placebo effect sizes through effects on expectations. Future analyses of placebo effects and their correlates should either focus on double-blind trials or compare results across levels of blinding. Related to this, the included meta-analyses pooled phase 2 and phase 3 trials (the latter of which will usually follow positive phase 2 trials), which might result in different expectation biases. Therefore, placebo effects should be compared between phase 2 and phase 3 trials in the future.
In this umbrella review, we found placebo effect sizes varied substantially across mental disorders. The sources of this variation remain unknown and require further study. Some variables were correlates of increased placebo response across mental disorders, including larger sample size, higher number of study sites, later publication year (opposite for ADHD), younger age, and increased baseline illness severity. There was also evidence that clinician-rated outcomes were associated with larger placebo effect sizes than self-rated or objective outcomes. We additionally identified important gaps in the literature, with no eligible systematic reviews identified in stress-related disorders, eating disorders, behavioural addictions, or bipolar mania. In relation to these disorders, some analyses have been published but they have not been included in systematic reviews/meta-analyses (e.g. analyses of individual patient data pooled across RCTs in acute mania [ 79 ] or gambling disorder [ 77 , 80 ]) and therefore were not eligible for inclusion here. We also focused on placebo response in RCTs of pharmacotherapies and neurostimulation interventions for mental disorders. We did not include placebo effects in psychosocial interventions, but such an analysis would also be valuable. Future studies should address these gaps in the literature and furthermore should compare findings in placebo arms with active treatment arms, both regarding treatment effect size and its correlates. Gaining additional insights into the placebo response may improve our ability to separate active treatment effects from placebo effects, thus paving the way for potentially effective new treatments for mental disorders.
The datasets generated during and/or analysed during the current study are available in the Open Science Framework repository, https://osf.io/fxvn4/ .
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Dr Nathan TM Huneke is an NIHR Academic Clinical Lecturer. The views expressed in this publication are those of the author(s) and not necessarily those of the NIHR, NHS, or the UK Department of Health and Social Care. For the purpose of open access, the author has applied a Creative Commons Attribution License (CC BY) to any Author Accepted Manuscript version arising from this submission.
NTMH, JA, DSB, SRC, CUC, MG, CMH, RH, ODH, JMAS, MS, and SCo conceptualized the study. NTMH, AB, VB, LE, CJG, OKF, LM, CR, SS, and SCo contributed to data collection, data curation, or data analysis. NTMH, MS, and SCo wrote the first draft of the manuscript. All authors had access to the raw data. All authors reviewed and edited the manuscript and had final responsibility for the decision to submit it for publication.
These authors contributed equally: Marco Solmi, Samuele Cortese.
Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
Nathan T. M. Huneke, Jay Amin, David S. Baldwin, Samuel R. Chamberlain, Matthew Garner, Catherine M. Hill, Ruihua Hou, Konstantinos Ioannidis, Julia M. A. Sinclair & Samuele Cortese
Southern Health NHS Foundation Trust, Southampton, UK
Nathan T. M. Huneke, Jay Amin, David S. Baldwin, Samuel R. Chamberlain, Konstantinos Ioannidis & Satneet Singh
University Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
David S. Baldwin
School of Psychology, University of Nottingham Malaysia, Semenyih, Malaysia
Alessio Bellato
Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK
Alessio Bellato, Valerie Brandt, Matthew Garner, Corentin J. Gosling, Claire Reed, Marco Solmi & Samuele Cortese
Clinic of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hanover, Germany
Valerie Brandt
Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany
Christoph U. Correll
Department of Psychiatry, Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, USA
Department of Psychiatry and Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA
Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY, USA
Faculty of Education and Psychology, University of Navarra, Pamplona, Spain
Luis Eudave
School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK
Matthew Garner
Université Paris Nanterre, DysCo Lab, F-92000, Nanterre, France
Corentin J. Gosling
Université de Paris, Laboratoire de Psychopathologie et Processus de Santé, F-92100, Boulogne-Billancourt, France
Department of Sleep Medicine, Southampton Children’s Hospital, Southampton, UK
Catherine M. Hill
Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Oliver D. Howes
H Lundbeck A/s, Iveco House, Watford, UK
Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Ole Köhler-Forsberg
Psychosis Research Unit, Aarhus University Hospital–Psychiatry, Aarhus, Denmark
Department of Translational Biomedicine and Neuroscience (DIBRAIN), University of Studies of Bari “Aldo Moro”, Bari, Italy
Lucia Marzulli
Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada
Marco Solmi
Department of Mental Health, Ottawa Hospital, Ottawa, ON, Canada
Ottawa Hospital Research Institute (OHRI) Clinical Epidemiology Program, University of Ottawa, Ottawa, ON, Canada
School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
Solent NHS Trust, Southampton, UK
Samuele Cortese
DiMePRe-J-Department of Precision and Regenerative Medicine-Jonic Area, University “Aldo Moro”, Bari, Italy
Hassenfeld Children’s Hospital at NYU Langone, New York University Child Study Center, New York, NY, USA
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Correspondence to Nathan T. M. Huneke .
Competing interests.
DSB is President of the British Association for Psychopharmacology, Editor of the Human Psychopharmacology journal (for which he receives an editor’s honorarium), and has received royalties from UpToDate. CMH has acted on an expert advisory board for Neurim Pharmaceuticals. ODH is a part-time employee and stockholder of Lundbeck A/s. He has received investigator-initiated research funding from and/or participated in advisory/speaker meetings organized by Angellini, Autifony, Biogen, Boehringer-Ingelheim, Eli Lilly, Heptares, Global Medical Education, Invicro, Jansenn, Lundbeck, Neurocrine, Otsuka, Sunovion, Recordati, Roche and Viatris/Mylan. ODH has a patent for the use of dopaminergic imaging. All other authors declare no competing interests. MS has received honoraria/has been a consultant for Angelini, Lundbeck, and Otsuka. SCo has received honoraria from non-profit associations (BAP, ACAMH, CADDRA) for educational activities and an honorarium from Medice. KI has received honoraria from Elsevier for editorial work. SRC receives honoraria from Elsevier for associate editor roles at comprehensive psychiatry and NBR journals. CUC has been a consultant and/or advisor to or has received honoraria from: AbbVie, Acadia, Adock Ingram, Alkermes, Allergan, Angelini, Aristo, Biogen, Boehringer-Ingelheim, Bristol-Meyers Squibb, Cardio Diagnostics, Cerevel, CNX Therapeutics, Compass Pathways, Darnitsa, Denovo, Gedeon Richter, Hikma, Holmusk, IntraCellular Therapies, Jamjoom Pharma, Janssen/J&J, Karuna, LB Pharma, Lundbeck, MedAvante-ProPhase, MedInCell, Merck, Mindpax, Mitsubishi Tanabe Pharma, Mylan, Neurocrine, Neurelis, Newron, Noven, Novo Nordisk, Otsuka, Pharmabrain, PPD Biotech, Recordati, Relmada, Reviva, Rovi, Sage, Seqirus, SK Life Science, Sumitomo Pharma America, Sunovion, Sun Pharma, Supernus, Takeda, Teva, Tolmar, Vertex, and Viatris. He provided expert testimony for Janssen and Otsuka. He served on a Data Safety Monitoring Board for Compass Pathways, Denovo, Lundbeck, Relmada, Reviva, Rovi, Supernus, and Teva. He has received grant support from Janssen and Takeda. He received royalties from UpToDate and is also a stock option holder of Cardio Diagnostics, Kuleon Biosciences, LB Pharma, Mindpax, and Quantic.
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41380_2024_2638_moesm1_esm.docx.
PLACEBO EFFECTS IN RANDOMIZED TRIALS OF PHARMACOLOGICAL AND NEUROSTIMULATION INTERVENTIONS FOR MENTAL DISORDERS: AN UMBRELLA REVIEW SUPPLEMENTARY APPENDIX
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Huneke, N.T.M., Amin, J., Baldwin, D.S. et al. Placebo effects in randomized trials of pharmacological and neurostimulation interventions for mental disorders: An umbrella review. Mol Psychiatry (2024). https://doi.org/10.1038/s41380-024-02638-x
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Received : 01 February 2024
Revised : 17 June 2024
Accepted : 19 June 2024
Published : 24 June 2024
DOI : https://doi.org/10.1038/s41380-024-02638-x
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Social‑ecological systems like fisheries provide food, livelihoods and recreation. However, lack of data and its integration into governance hinders their conservation and management. Stakeholders possess site‑specific knowledge crucial for confronting these challenges. There is increasing recognition that Indigenous and local knowledge (ILK) is valuable, but structural differences between ILK and quantitative archetypes have stalled the assimilation of ILK into fisheries management, despite acknowledged bias and uncertainty in scientific methods. Conducting a systematic review of fisheries‑associated ILK research (n = 397 articles), we examined how ILK is accessed, applied, distributed across space and species, and has evolved. We show that ILK has generated qualitative, semi‑quantitative and quantitative information for diverse taxa across 98 countries. Fisheries‑associated ILK research mostly targets small‑scale and artisanal fishers (70% of studies) and typically uses semi‑structured interviews (60%). We revealed large variability in sample size (n = 4–7638), predicted by the approach employed and the data generated (i.e. qualitative studies target smaller groups). Using thematic categorisation, we show that scientists are still exploring techniques, or 'validating' ILK through comparisons with quantitative scientific data (20%), and recording qualitative information of what fishers understand (40%). A few researchers are applying quantitative social science methods to derive trends in abundance, catch and effort. Such approaches facilitate recognition of local insight in fisheries management but fall short of accepting ILK as a valid complementary way of knowing about fisheries systems. This synthesis reveals that development and increased opportunities are needed to bridge ILK and quantitative scientific data.
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2. Read the article thoroughly: Carefully read the article multiple times to get a complete understanding of its content, arguments, and conclusions. As you read, take notes on key points, supporting evidence, and any areas that require further exploration or clarification. 3. Summarize the main ideas: In your review's introduction, briefly ...
There is a continuing need to support researchers in the creation of innovative research questions and hypotheses, as well as for journal articles that carefully review these elements.1 When research questions and hypotheses are not carefully thought of, unethical studies and poor outcomes usually ensue. Carefully formulated research questions ...
3. Identify the article. Start your review by referring to the title and author of the article, the title of the journal, and the year of publication in the first paragraph. For example: The article, "Condom use will increase the spread of AIDS," was written by Anthony Zimmerman, a Catholic priest.
2. Benefits of Review Articles to the Author. Analysing literature gives an overview of the "WHs": WHat has been reported in a particular field or topic, WHo the key writers are, WHat are the prevailing theories and hypotheses, WHat questions are being asked (and answered), and WHat methods and methodologies are appropriate and useful [].For new or aspiring researchers in a particular ...
Meta-analysis is the most popular example of quantitative systematic review types. Highlights. Review articles summarize the current state of evidence on a particular topic. Review articles translate the relevance of evidence for readers. Independent of the review type, all reviews must have a predefined methodology.
Students will read selected article critically and write a review of the article. This review essay should contain two components: (1) the assessment of the author's main argument or thesis statement by reviewing how the author (s) uses both qualitative and quantitative evidences in the articles; and (2) the assessment of the use, misuse, and ...
For example: Qualitative versus quantitative research; Empirical versus theoretical scholarship; Divide the research by sociological, historical, or cultural sources; Theoretical: In many humanities articles, the literature review is the foundation for the theoretical framework. You can use it to discuss various theories, models, and ...
This article is a practical guide to conducting data analysis in general literature reviews. The general literature review is a synthesis and analysis of published research on a relevant clinical issue, and is a common format for academic theses at the bachelor's and master's levels in nursing, physiotherapy, occupational therapy, public health and other related fields.
Actions to Take. 1. Skim the article without taking notes: Read the abstract. The abstract will tell you the major findings of the article and why they matter. Read first for the "big picture.". Note any terms or techniques you need to define. Jot down any questions or parts you don't understand.
Step 1: Define the right organization for your review. Knowing the future setup of your paper will help you define how you should read the article. Here are the steps to follow: Summarize the article — seek out the main points, ideas, claims, and general information presented in the article.
Revised on June 22, 2023. Quantitative research is the process of collecting and analyzing numerical data. It can be used to find patterns and averages, make predictions, test causal relationships, and generalize results to wider populations. Quantitative research is the opposite of qualitative research, which involves collecting and analyzing ...
The amount of detail should match the amount needed by the audience. Use the guidelines (e.g., proposal guidelines, publisher guidelines for authors) to write a literature review as a back- ground to the proposed research. Previous findings are usually needed and frequently previous meth- ods are also important.
Article Review vs. Response Paper . Now, let's consider the difference between an article review and a response paper: If you're assigned to critique a scholarly article, you will need to compose an article review.; If your subject of analysis is a popular article, you can respond to it with a well-crafted response paper.; The reason for such distinctions is the quality and structure of ...
article pro vides the practical points of conducting a formally written quantitative research article critique while providing a brief example to demonstrate the principles and form.
to identify what is best practice. This article is a step-by step-approach to critiquing quantitative research to help nurses demystify the process and decode the terminology. Key words: Quantitative research methodologies Review process • Research]or many qualified nurses and nursing students research is research, and it is often quite difficult
A systematic review is a type of review that uses repeatable methods to find, select, and synthesize all available evidence. It answers a clearly formulated research question and explicitly states the methods used to arrive at the answer. Example: Systematic review. In 2008, Dr. Robert Boyle and his colleagues published a systematic review in ...
The first step in the critique process is for the reader to browse the abstract and article for an overview. During this initial review a great deal of information can be obtained. The abstract should provide a clear, concise overview of the study. During this review it should be noted if the title, problem statement, and research question (or ...
In The Literature Review: A Step-by-Step Guide for Students, Ridley presents that literature reviews serve several purposes (2008, p. 16-17). Included are the following points: Historical background for the research; Overview of current field provided by "contemporary debates, issues, and questions;" Theories and concepts related to your research;
Title, keywords and the authors. The title of a paper should be clear and give a good idea of the subject area. The title should not normally exceed 15 words 2 and should attract the attention of the reader. 3 The next step is to review the key words. These should provide information on both the ideas or concepts discussed in the paper and the ...
Because there are few published examples of critique examples, this article provides the practical points of conducting a formally written quantitative research article critique while providing a brief example to demonstrate the principles and form. Keywords: quantitative article critique, statistics, methodology, graduate students Introduction
When collecting and analyzing data, quantitative research deals with numbers and statistics, while qualitative research deals with words and meanings. Both are important for gaining different kinds of knowledge. Quantitative research. Quantitative research is expressed in numbers and graphs. It is used to test or confirm theories and assumptions.
The integrative review (IR) is an important methodology to provide a comprehensive view of a topic. A distinguishing feature of the IR is the use of diverse data sources. The complexity inherent to the IR process increases the degree of rigor required. This article uses an example IR to demonstrate key points and lessons learned during the process.
Examples of Article Critique For Students Psychology Article Critique. Reference: Smith, J. A., & Brown, R. L. (2022). ... "The article offers a comprehensive review of the impacts of deforestation on climate change, but it would be strengthened by incorporating more case studies from diverse geographic regions." ... Quantitative Article ...
In this descriptive-analytical quantitative study, the sample size was calculated using Cochrane's formula and considering a p-value of 0.51, α = 0.05, and d = 0.05, and 313 students were selected based on stratified and random method. To gather data and assess various aspects of variables, a questionnaires were utilized, focusing on health ...
For example, we included physical activity-based interventions if they involved an element of education, training or service support, but we excluded studies which involved exercise only. ... Quantitative review methods - A systematic review and metaethnography to identify how effective, cost-effective, accessible and acceptable self-management ...
This study examines the integration of epistemological principles into road infrastructure risk management, emphasizing the need for adaptive strategies in the face of inherent climate uncertainties, particularly flash floods. A systematic review of peer-reviewed articles, industry reports, and case studies from the past two decades was conducted, focusing on the application of epistemological ...
There is a growing literature exploring the placebo response within specific mental disorders, but no overarching quantitative synthesis of this research has analyzed evidence across mental disorders.
Conducting a systematic review of fisheries‑associated ILK research (n = 397 articles), we examined how ILK is accessed, applied, distributed across space and species, and has evolved. We show that ILK has generated qualitative, semi‑quantitative and quantitative information for diverse taxa across 98 countries.