title of research study example 1

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How to Make a Research Paper Title with Examples

What is a research paper title and why does it matter?

A research paper title summarizes the aim and purpose of your research study. Making a title for your research is one of the most important decisions when writing an article to publish in journals. The research title is the first thing that journal editors and reviewers see when they look at your paper and the only piece of information that fellow researchers will see in a database or search engine query. Good titles that are concise and contain all the relevant terms have been shown to increase citation counts and Altmetric scores .

Therefore, when you title research work, make sure it captures all of the relevant aspects of your study, including the specific topic and problem being investigated. It also should present these elements in a way that is accessible and will captivate readers. Follow these steps to learn how to make a good research title for your work.

How to Make a Research Paper Title in 5 Steps

You might wonder how you are supposed to pick a title from all the content that your manuscript contains—how are you supposed to choose? What will make your research paper title come up in search engines and what will make the people in your field read it? 

In a nutshell, your research title should accurately capture what you have done, it should sound interesting to the people who work on the same or a similar topic, and it should contain the important title keywords that other researchers use when looking for literature in databases. To make the title writing process as simple as possible, we have broken it down into 5 simple steps.

Step 1: Answer some key questions about your research paper

What does your paper seek to answer and what does it accomplish? Try to answer these questions as briefly as possible. You can create these questions by going through each section of your paper and finding the MOST relevant information to make a research title.

Step 2: Identify research study keywords

Now that you have answers to your research questions, find the most important parts of these responses and make these your study keywords. Note that you should only choose the most important terms for your keywords–journals usually request anywhere from 3 to 8 keywords maximum.

Step 3: Research title writing: use these keywords

“We employed a case study of 60 liver transplant patients around the US aged 20-50 years to assess how waiting list volume affects the outcomes of liver transplantation in patients; results indicate a positive correlation between increased waiting list volume and negative prognosis after the transplant procedure.”

The sentence above is clearly much too long for a research paper title. This is why you will trim and polish your title in the next two steps.

Step 4: Create a working research paper title

To create a working title, remove elements that make it a complete “sentence” but keep everything that is important to what the study is about. Delete all unnecessary and redundant words that are not central to the study or that researchers would most likely not use in a database search.

“ We employed a case study of 60 liver transplant patients around the US aged 20-50 years to assess how the waiting list volume affects the outcome of liver transplantation in patients ; results indicate a positive correlation between increased waiting list volume and a negative prognosis after transplant procedure ”

Now shift some words around for proper syntax and rephrase it a bit to shorten the length and make it leaner and more natural. What you are left with is:

“A case study of 60 liver transplant patients around the US aged 20-50 years assessing the impact of waiting list volume on outcome of transplantation and showing a positive correlation between increased waiting list volume and a negative prognosis” (Word Count: 38)

This text is getting closer to what we want in a research title, which is just the most important information. But note that the word count for this working title is still 38 words, whereas the average length of published journal article titles is 16 words or fewer. Therefore, we should eliminate some words and phrases that are not essential to this title.

Step 5: Remove any nonessential words and phrases from your title

Because the number of patients studied and the exact outcome are not the most essential parts of this paper, remove these elements first:

 “A case study of 60 liver transplant patients around the US aged 20-50 years assessing the impact of waiting list volume on outcomes of transplantation and showing a positive correlation between increased waiting list volume and a negative prognosis” (Word Count: 19)

In addition, the methods used in a study are not usually the most searched-for keywords in databases and represent additional details that you may want to remove to make your title leaner. So what is left is:

“Assessing the impact of waiting list volume on outcome and prognosis in liver transplantation patients” (Word Count: 15)

In this final version of the title, one can immediately recognize the subject and what objectives the study aims to achieve. Note that the most important terms appear at the beginning and end of the title: “Assessing,” which is the main action of the study, is placed at the beginning; and “liver transplantation patients,” the specific subject of the study, is placed at the end.

This will aid significantly in your research paper title being found in search engines and database queries, which means that a lot more researchers will be able to locate your article once it is published. In fact, a 2014 review of more than 150,000 papers submitted to the UK’s Research Excellence Framework (REF) database found the style of a paper’s title impacted the number of citations it would typically receive. In most disciplines, articles with shorter, more concise titles yielded more citations.

Adding a Research Paper Subtitle

If your title might require a subtitle to provide more immediate details about your methodology or sample, you can do this by adding this information after a colon:

“ : a case study of US adult patients ages 20-25”

If we abide strictly by our word count rule this may not be necessary or recommended. But every journal has its own standard formatting and style guidelines for research paper titles, so it is a good idea to be aware of the specific journal author instructions , not just when you write the manuscript but also to decide how to create a good title for it.

Research Paper Title Examples

The title examples in the following table illustrate how a title can be interesting but incomplete, complete by uninteresting, complete and interesting but too informal in tone, or some other combination of these. A good research paper title should meet all the requirements in the four columns below.

Tips on Formulating a Good Research Paper Title

In addition to the steps given above, there are a few other important things you want to keep in mind when it comes to how to write a research paper title, regarding formatting, word count, and content:

• Write the title after you’ve written your paper and abstract
• Include all of the essential terms in your paper
• Keep it short and to the point (~16 words or fewer)
• Avoid unnecessary jargon and abbreviations
• Use keywords that capture the content of your paper
• Never include a period at the end—your title is NOT a sentence

Research Paper Writing Resources

We hope this article has been helpful in teaching you how to craft your research paper title. But you might still want to dig deeper into different journal title formats and categories that might be more suitable for specific article types or need help with writing a cover letter for your manuscript submission.

In addition to getting English proofreading services , including paper editing services , before submission to journals, be sure to visit our academic resources papers. Here you can find dozens of articles on manuscript writing, from drafting an outline to finding a target journal to submit to.

6 Important Tips on Writing a Research Paper Title

When you are searching for a research study on a particular topic, you probably notice that articles with interesting, descriptive research titles draw you in. By contrast, research paper titles that are not descriptive are usually passed over, even though you may write a good research paper with interesting contents. This shows the importance of coming up with a good title for your research paper when drafting your own manuscript.

Importance of a Research Title

The research title plays a crucial role in the research process, and its importance can be summarized as follows:

Why do Research Titles Matter?

Before we look at how to title a research paper, let’s look at a research title example that illustrates why a good research paper should have a strong title.

Imagine that you are researching meditation and nursing, and you want to find out if any studies have shown that meditation makes nurses better communicators.  You conduct a keyword search using the keywords “nursing”, “communication”, and “meditation.” You come up with results that have the following titles:

• Benefits of Meditation for the Nursing Profession: A Quantitative Investigation
• Why Mindful Nurses Make the Best Communicators
• Meditation Gurus
• Nurses on the Move: A Quantitative Report on How Meditation Can Improve Nurse Performance

All four of these research paper titles may describe very similar studies—they could even be titles for the same study! As you can see, they give very different impressions.

• Title 1 describes the topic and the method of the study but is not particularly catchy.
• Title 2 partly describes the topic, but does not give any information about the method of the study—it could simply be a theoretical or opinion piece.
• Title 3 is somewhat catchier but gives almost no information at all about the article.
• Title 4 begins with a catchy main title and is followed by a subtitle that gives information about the content and method of the study.

As we will see, Title 4 has all the characteristics of a good research title.

Characteristics of a Good Research Title

According to rhetoric scholars Hairston and Keene, making a good title for a paper involves ensuring that the title of the research accomplishes four goals as mentioned below:

• It should predict the content of the research paper .
• It should be interesting to the reader .
• It should reflect the tone of the writing .
• It should contain important keywords that will make it easier to be located during a keyword search.

Let’s return to the examples in the previous section to see how to make a research title.

As you can see in the table above, only one of the four example titles fulfills all of the criteria of a suitable research paper title.

Related: You’ve chosen your study topic, but having trouble deciding where to publish it? Here’s a comprehensive course to help you identify the right journal .

Tips for Writing an Effective Research Paper Title

When writing a research title, you can use the four criteria listed above as a guide. Here are a few other tips you can use to make sure your title will be part of the recipe for an effective research paper :

• Make sure your research title describes (a) the topic, (b) the method, (c) the sample, and (d) the results of your study. You can use the following formula:

[ Result ]: A [ method ] study of [ topic ] among [ sample ] Example : Meditation makes nurses perform better: a qualitative study of mindfulness meditation among German nursing students

• Avoid unnecessary words and jargons. Keep the title statement as concise as possible. You want a title that will be comprehensible even to people who are not experts in your field. Check our article for a detailed list of things to avoid when writing an effective research title .
• Make sure your title is between 5 and 15 words in length.
• If you are writing a title for a university assignment or for a particular academic journal, verify that your title conforms to the standards and requirements for that outlet. For example, many journals require that titles fall under a character limit, including spaces. Many universities require that titles take a very specific form, limiting your creativity.
• Use a descriptive phrase to convey the purpose of your research efficiently.
• Most importantly, use critical keywords in the title to increase the discoverability of your article.

Resources for Further Reading

In addition to the tips above, there are many resources online that you can use to help write your research title. Here is a list of links that you may find useful as you work on creating an excellent research title:

• The University of Southern California has a guide specific to social science research papers: http://libguides.usc.edu/writingguide/title
• The Journal of European Psychology Students has a blog article focusing on APA-compliant research paper titles: http://blog.efpsa.org/2012/09/01/how-to-write-a-good-title-for-journal-articles/
• This article by Kristen Hamlin contains a step-by-step approach to writing titles: http://classroom.synonym.com/choose-title-research-paper-4332.html

Are there any tips or tricks you find useful in crafting research titles? Which tip did you find most useful in this article? Leave a comment to let us know!

• Hairston, M., & Keene, M. 2003. Successful writing . 5th ed. New York: Norton.
• University of Southern California. 2017. Organizing your social sciences research paper: choosing a title . [Online] Available at: http://libguides.usc.edu/writingguide/title

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Thank you for the excellent article and tips for creating a research work, because I always forget about such an essential element as the keywords when forming topics. In particular, I have found a rapid help with the formation of informative and sound titles that also conforms to the standards and requirements.

I am doing a research work on sales girls or shop girls using qualititative method. Basicly I am from Pakistan and writing on the scenario of mycountry. I am really confused about my research title can you kindly give some suggestions and give me an approperaite tilte

Hi Zubair, Thank you for your question. However, the information you have provided is insufficient for drafting an appropriate title. Information on what exactly you intend to study would be needed in order to draft a meaningful title. Meanwhile, you can try drafting your own title after going through the following articles our website: https://www.enago.com/academy/top-10-tips-on-choosing-an-attractive-research-title/ , https://www.enago.com/academy/writing-a-good-research-title-things-to-avoid/ , https://www.enago.com/academy/write-irresistible-research-paper-title/ We would be happy to give you feedback and suggest changes if required. Did you get a chance to install our free Mobile App? https://www.enago.com/academy/mobile-app/ . Make sure you subscribe to our weekly newsletter https://www.enago.com/academy/subscribe-now/ .

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Thank you for this. It helped me improve my research title. I just want to verify to you the title I have just made. “Ensuring the safety: A Quantitative Study of Radio Frequency Identification system among the selected students of ( school’s name ).

(I need your reply asap coz we will be doing the chap. 1 tomorrow. Thank u in advance. 🙂 )

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Hi Joan, Thank you for your question. We are glad to know that you found our resources useful. Your feedback is very valuable to us. You can try drafting your own title after going through the following articles on our website: https://www.enago.com/academy/top-10-tips-on-choosing-an-attractive-research-title/ , https://www.enago.com/academy/writing-a-good-research-title-things-to-avoid/ , https://www.enago.com/academy/write-irresistible-research-paper-title/

We would be happy to give you feedback and suggest changes if required. Did you get a chance to install our free Mobile App? https://www.enago.com/academy/mobile-app/ . Make sure you subscribe to our weekly newsletter https://www.enago.com/academy/subscribe-now/ .

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I need help. I need a research title for my study about early mobilization of the mechanically ventilated patients in the ICU. Any suggestions would be highly appreciated.

Thank you for posting your query on the website. When writing manuscripts, too many scholars neglect the research title. This phrase, along with the abstract, is what people will mostly see and read online. Title research of publications shows that the research paper title does matter a lot. Both bibliometrics and altmetrics tracking of citations are now, for better or worse, used to gauge a paper’s “success” for its author(s) and the journal publishing it. Interesting research topics coupled with good or clever yet accurate research titles can draw more attention to your work from peers and the public alike. You can check through the following search results for titles on similar topics: https://www.google.com/search?q=early+mobilization+of+the+mechanically+ventilated+patients+in+the+icu&rlz=1C1GCEU_enIN907IN907&oq=&aqs=chrome.0.69i59.4920093j0j7&sourceid=chrome&ie=UTF-8 .

We hope this would be helpful in drafting an attractive title for your research paper.

Please let us know in case of any other queries.

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How to write a good research paper title

“Unread science is lost science .”

Credit: Mykyta Dolmatov/Getty

“Unread science is lost science.”

28 July 2020

Mykyta Dolmatov/Getty

With the influx of publications brought on by the pandemic, it’s become more challenging than ever for researchers to attract attention to their work.

Understanding which elements of a title will attract readers – or turn them away – has been proven to increase a paper’s citations and Altmetric score .

“In the era of information overload, most students and researchers do not have time to browse the entire text of a paper,” says Patrick Pu , a librarian at the National University of Singapore.

“The title of a paper, together with its abstract, become very important to capture and sustain the attention of readers.”

1. A good title avoids technical language

Since the primary audience of a paper is likely to be researchers working in the same field, using technical language in the title seems to make sense.

But this alienates the wider lay audience, which can bring valuable attention to your work . It can also alienate inexperienced researchers, or those who have recently entered the field.

“A good title does not use unnecessary jargon,” says Elisa De Ranieri , editor-in-chief at the Nature Communications journal (published by Springer Nature, which also publishes Nature Index.) “It communicates the main results in the study in a way that is clear and accessible, ideally to non-specialists or researchers new to the field.”

How-to: When crafting a title, says De Ranieri, write down the main result of the manuscript in a short paragraph. Shorten the text to make it more concise, while still remaining descriptive. Repeat this process until you have a title of fewer than 15 words.

2. A good title is easily searchable

Most readers today are accessing e-journals, which are indexed in scholarly databases such as Scopus and Google Scholar.

“Although these databases usually index the full text of papers, retrieval weightage for ‘Title’ is usually higher than other fields, such as ‘Results’,” Pu explains.

At the National University of Singapore, Pu and his colleagues run information literacy programmes for editors and authors. They give advice for publishing best practice, such as how to identify the most commonly used keywords in literature searches in a given field.

“A professor once told us how he discovered that industry experts were using a different term or keyword to describe his research area,” says Pu.

“He had written a seminal paper that did not include this ‘industry keyword’. He believes his paper, which was highly cited by academics, would have a higher citation count if he had included this keyword in the title. As librarians, we try to highlight this example to our students so that they will consider all possible keywords to use in their searches and paper titles.”

How-to: Authors should speak to an academic librarian at their institution to gain an understanding of keyword and search trends in their field of research. This should inform how the paper title is written.

3. A good title is substantiated by data

Authors should be cautious to not make any claims in the title that can’t be backed up by evidence.

“For instance, if you make a discovery with potential therapeutic relevance, the title should specify whether it was tested or studied in animals or humans/human samples,” says Irene Jarchum , senior editor at the journal Nature Biotechnology (also published by Springer Nature, which publishes the Nature Index.)

Jarchum adds that titles can be contentious because different authors have different views on the use of specific words, such as acronyms, or more fundamentally, what the main message of the title should be.

Some authors may over-interpret the significance of their preliminary findings, and want to reflect this in the title.

How-to: If you know your paper will be contentious within the scientific community, have the data ready to defend your decisions .

4. A good title sparks curiosity

A one-liner that sparks a reader’s interest can be very effective.

“A title has to pique the interest of the person searching for literature in a split-second – enough that they click on the title to read the abstract. Unread science is lost science,” says Christine Mayer , editor-in-chief of the journal Advanced Therapeutics .

Paper titles such as, "White and wonderful? Microplastics prevail in snow from the Alps to the Arctic" ( 2019 Science ), and “Kids these days: Why the youth of today seem lacking” ( 2019 Science Advances ) are good examples of this principle. Both papers have high Altmetric Attention scores, indicating that they have been widely read and discussed online.

How-to: Take note of the characteristics of paper titles that spark your own interest. Keep a record of these and apply the same principles to your own paper titles.

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Writing the title and abstract for a research paper: Being concise, precise, and meticulous is the key

Milind s. tullu.

Department of Pediatrics, Seth G.S. Medical College and KEM Hospital, Parel, Mumbai, Maharashtra, India

This article deals with formulating a suitable title and an appropriate abstract for an original research paper. The “title” and the “abstract” are the “initial impressions” of a research article, and hence they need to be drafted correctly, accurately, carefully, and meticulously. Often both of these are drafted after the full manuscript is ready. Most readers read only the title and the abstract of a research paper and very few will go on to read the full paper. The title and the abstract are the most important parts of a research paper and should be pleasant to read. The “title” should be descriptive, direct, accurate, appropriate, interesting, concise, precise, unique, and should not be misleading. The “abstract” needs to be simple, specific, clear, unbiased, honest, concise, precise, stand-alone, complete, scholarly, (preferably) structured, and should not be misrepresentative. The abstract should be consistent with the main text of the paper, especially after a revision is made to the paper and should include the key message prominently. It is very important to include the most important words and terms (the “keywords”) in the title and the abstract for appropriate indexing purpose and for retrieval from the search engines and scientific databases. Such keywords should be listed after the abstract. One must adhere to the instructions laid down by the target journal with regard to the style and number of words permitted for the title and the abstract.

Introduction

This article deals with drafting a suitable “title” and an appropriate “abstract” for an original research paper. Because the “title” and the “abstract” are the “initial impressions” or the “face” of a research article, they need to be drafted correctly, accurately, carefully, meticulously, and consume time and energy.[ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ] Often, these are drafted after the complete manuscript draft is ready.[ 2 , 3 , 4 , 5 , 9 , 10 , 11 ] Most readers will read only the title and the abstract of a published research paper, and very few “interested ones” (especially, if the paper is of use to them) will go on to read the full paper.[ 1 , 2 ] One must remember to adhere to the instructions laid down by the “target journal” (the journal for which the author is writing) regarding the style and number of words permitted for the title and the abstract.[ 2 , 4 , 5 , 7 , 8 , 9 , 12 ] Both the title and the abstract are the most important parts of a research paper – for editors (to decide whether to process the paper for further review), for reviewers (to get an initial impression of the paper), and for the readers (as these may be the only parts of the paper available freely and hence, read widely).[ 4 , 8 , 12 ] It may be worth for the novice author to browse through titles and abstracts of several prominent journals (and their target journal as well) to learn more about the wording and styles of the titles and abstracts, as well as the aims and scope of the particular journal.[ 5 , 7 , 9 , 13 ]

The details of the title are discussed under the subheadings of importance, types, drafting, and checklist.

Importance of the title

When a reader browses through the table of contents of a journal issue (hard copy or on website), the title is the “ first detail” or “face” of the paper that is read.[ 2 , 3 , 4 , 5 , 6 , 13 ] Hence, it needs to be simple, direct, accurate, appropriate, specific, functional, interesting, attractive/appealing, concise/brief, precise/focused, unambiguous, memorable, captivating, informative (enough to encourage the reader to read further), unique, catchy, and it should not be misleading.[ 1 , 2 , 3 , 4 , 5 , 6 , 9 , 12 ] It should have “just enough details” to arouse the interest and curiosity of the reader so that the reader then goes ahead with studying the abstract and then (if still interested) the full paper.[ 1 , 2 , 4 , 13 ] Journal websites, electronic databases, and search engines use the words in the title and abstract (the “keywords”) to retrieve a particular paper during a search; hence, the importance of these words in accessing the paper by the readers has been emphasized.[ 3 , 4 , 5 , 6 , 12 , 14 ] Such important words (or keywords) should be arranged in appropriate order of importance as per the context of the paper and should be placed at the beginning of the title (rather than the later part of the title, as some search engines like Google may just display only the first six to seven words of the title).[ 3 , 5 , 12 ] Whimsical, amusing, or clever titles, though initially appealing, may be missed or misread by the busy reader and very short titles may miss the essential scientific words (the “keywords”) used by the indexing agencies to catch and categorize the paper.[ 1 , 3 , 4 , 9 ] Also, amusing or hilarious titles may be taken less seriously by the readers and may be cited less often.[ 4 , 15 ] An excessively long or complicated title may put off the readers.[ 3 , 9 ] It may be a good idea to draft the title after the main body of the text and the abstract are drafted.[ 2 , 3 , 4 , 5 ]

Types of titles

Titles can be descriptive, declarative, or interrogative. They can also be classified as nominal, compound, or full-sentence titles.

Descriptive or neutral title

This has the essential elements of the research theme, that is, the patients/subjects, design, interventions, comparisons/control, and outcome, but does not reveal the main result or the conclusion.[ 3 , 4 , 12 , 16 ] Such a title allows the reader to interpret the findings of the research paper in an impartial manner and with an open mind.[ 3 ] These titles also give complete information about the contents of the article, have several keywords (thus increasing the visibility of the article in search engines), and have increased chances of being read and (then) being cited as well.[ 4 ] Hence, such descriptive titles giving a glimpse of the paper are generally preferred.[ 4 , 16 ]

Declarative title

This title states the main finding of the study in the title itself; it reduces the curiosity of the reader, may point toward a bias on the part of the author, and hence is best avoided.[ 3 , 4 , 12 , 16 ]

Interrogative title

This is the one which has a query or the research question in the title.[ 3 , 4 , 16 ] Though a query in the title has the ability to sensationalize the topic, and has more downloads (but less citations), it can be distracting to the reader and is again best avoided for a research article (but can, at times, be used for a review article).[ 3 , 6 , 16 , 17 ]

From a sentence construct point of view, titles may be nominal (capturing only the main theme of the study), compound (with subtitles to provide additional relevant information such as context, design, location/country, temporal aspect, sample size, importance, and a provocative or a literary; for example, see the title of this review), or full-sentence titles (which are longer and indicate an added degree of certainty of the results).[ 4 , 6 , 9 , 16 ] Any of these constructs may be used depending on the type of article, the key message, and the author's preference or judgement.[ 4 ]

Drafting a suitable title

A stepwise process can be followed to draft the appropriate title. The author should describe the paper in about three sentences, avoiding the results and ensuring that these sentences contain important scientific words/keywords that describe the main contents and subject of the paper.[ 1 , 4 , 6 , 12 ] Then the author should join the sentences to form a single sentence, shorten the length (by removing redundant words or adjectives or phrases), and finally edit the title (thus drafted) to make it more accurate, concise (about 10–15 words), and precise.[ 1 , 3 , 4 , 5 , 9 ] Some journals require that the study design be included in the title, and this may be placed (using a colon) after the primary title.[ 2 , 3 , 4 , 14 ] The title should try to incorporate the Patients, Interventions, Comparisons and Outcome (PICO).[ 3 ] The place of the study may be included in the title (if absolutely necessary), that is, if the patient characteristics (such as study population, socioeconomic conditions, or cultural practices) are expected to vary as per the country (or the place of the study) and have a bearing on the possible outcomes.[ 3 , 6 ] Lengthy titles can be boring and appear unfocused, whereas very short titles may not be representative of the contents of the article; hence, optimum length is required to ensure that the title explains the main theme and content of the manuscript.[ 4 , 5 , 9 ] Abbreviations (except the standard or commonly interpreted ones such as HIV, AIDS, DNA, RNA, CDC, FDA, ECG, and EEG) or acronyms should be avoided in the title, as a reader not familiar with them may skip such an article and nonstandard abbreviations may create problems in indexing the article.[ 3 , 4 , 5 , 6 , 9 , 12 ] Also, too much of technical jargon or chemical formulas in the title may confuse the readers and the article may be skipped by them.[ 4 , 9 ] Numerical values of various parameters (stating study period or sample size) should also be avoided in the titles (unless deemed extremely essential).[ 4 ] It may be worthwhile to take an opinion from a impartial colleague before finalizing the title.[ 4 , 5 , 6 ] Thus, multiple factors (which are, at times, a bit conflicting or contrasting) need to be considered while formulating a title, and hence this should not be done in a hurry.[ 4 , 6 ] Many journals ask the authors to draft a “short title” or “running head” or “running title” for printing in the header or footer of the printed paper.[ 3 , 12 ] This is an abridged version of the main title of up to 40–50 characters, may have standard abbreviations, and helps the reader to navigate through the paper.[ 3 , 12 , 14 ]

Checklist for a good title

Table 1 gives a checklist/useful tips for drafting a good title for a research paper.[ 1 , 2 , 3 , 4 , 5 , 6 , 12 ] Table 2 presents some of the titles used by the author of this article in his earlier research papers, and the appropriateness of the titles has been commented upon. As an individual exercise, the reader may try to improvise upon the titles (further) after reading the corresponding abstract and full paper.

Checklist/useful tips for drafting a good title for a research paper

Some titles used by author of this article in his earlier publications and remark/comment on their appropriateness

The Abstract

The details of the abstract are discussed under the subheadings of importance, types, drafting, and checklist.

Importance of the abstract

The abstract is a summary or synopsis of the full research paper and also needs to have similar characteristics like the title. It needs to be simple, direct, specific, functional, clear, unbiased, honest, concise, precise, self-sufficient, complete, comprehensive, scholarly, balanced, and should not be misleading.[ 1 , 2 , 3 , 7 , 8 , 9 , 10 , 11 , 13 , 17 ] Writing an abstract is to extract and summarize (AB – absolutely, STR – straightforward, ACT – actual data presentation and interpretation).[ 17 ] The title and abstracts are the only sections of the research paper that are often freely available to the readers on the journal websites, search engines, and in many abstracting agencies/databases, whereas the full paper may attract a payment per view or a fee for downloading the pdf copy.[ 1 , 2 , 3 , 7 , 8 , 10 , 11 , 13 , 14 ] The abstract is an independent and stand-alone (that is, well understood without reading the full paper) section of the manuscript and is used by the editor to decide the fate of the article and to choose appropriate reviewers.[ 2 , 7 , 10 , 12 , 13 ] Even the reviewers are initially supplied only with the title and the abstract before they agree to review the full manuscript.[ 7 , 13 ] This is the second most commonly read part of the manuscript, and therefore it should reflect the contents of the main text of the paper accurately and thus act as a “real trailer” of the full article.[ 2 , 7 , 11 ] The readers will go through the full paper only if they find the abstract interesting and relevant to their practice; else they may skip the paper if the abstract is unimpressive.[ 7 , 8 , 9 , 10 , 13 ] The abstract needs to highlight the selling point of the manuscript and succeed in luring the reader to read the complete paper.[ 3 , 7 ] The title and the abstract should be constructed using keywords (key terms/important words) from all the sections of the main text.[ 12 ] Abstracts are also used for submitting research papers to a conference for consideration for presentation (as oral paper or poster).[ 9 , 13 , 17 ] Grammatical and typographic errors reflect poorly on the quality of the abstract, may indicate carelessness/casual attitude on part of the author, and hence should be avoided at all times.[ 9 ]

Types of abstracts

The abstracts can be structured or unstructured. They can also be classified as descriptive or informative abstracts.

Structured and unstructured abstracts

Structured abstracts are followed by most journals, are more informative, and include specific subheadings/subsections under which the abstract needs to be composed.[ 1 , 7 , 8 , 9 , 10 , 11 , 13 , 17 , 18 ] These subheadings usually include context/background, objectives, design, setting, participants, interventions, main outcome measures, results, and conclusions.[ 1 ] Some journals stick to the standard IMRAD format for the structure of the abstracts, and the subheadings would include Introduction/Background, Methods, Results, And (instead of Discussion) the Conclusion/s.[ 1 , 2 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 17 , 18 ] Structured abstracts are more elaborate, informative, easy to read, recall, and peer-review, and hence are preferred; however, they consume more space and can have same limitations as an unstructured abstract.[ 7 , 9 , 18 ] The structured abstracts are (possibly) better understood by the reviewers and readers. Anyway, the choice of the type of the abstract and the subheadings of a structured abstract depend on the particular journal style and is not left to the author's wish.[ 7 , 10 , 12 ] Separate subheadings may be necessary for reporting meta-analysis, educational research, quality improvement work, review, or case study.[ 1 ] Clinical trial abstracts need to include the essential items mentioned in the CONSORT (Consolidated Standards Of Reporting Trials) guidelines.[ 7 , 9 , 14 , 19 ] Similar guidelines exist for various other types of studies, including observational studies and for studies of diagnostic accuracy.[ 20 , 21 ] A useful resource for the above guidelines is available at www.equator-network.org (Enhancing the QUAlity and Transparency Of health Research). Unstructured (or non-structured) abstracts are free-flowing, do not have predefined subheadings, and are commonly used for papers that (usually) do not describe original research.[ 1 , 7 , 9 , 10 ]

The four-point structured abstract: This has the following elements which need to be properly balanced with regard to the content/matter under each subheading:[ 9 ]

Background and/or Objectives: This states why the work was undertaken and is usually written in just a couple of sentences.[ 3 , 7 , 8 , 9 , 10 , 12 , 13 ] The hypothesis/study question and the major objectives are also stated under this subheading.[ 3 , 7 , 8 , 9 , 10 , 12 , 13 ]

Methods: This subsection is the longest, states what was done, and gives essential details of the study design, setting, participants, blinding, sample size, sampling method, intervention/s, duration and follow-up, research instruments, main outcome measures, parameters evaluated, and how the outcomes were assessed or analyzed.[ 3 , 7 , 8 , 9 , 10 , 12 , 13 , 14 , 17 ]

Results/Observations/Findings: This subheading states what was found, is longer, is difficult to draft, and needs to mention important details including the number of study participants, results of analysis (of primary and secondary objectives), and include actual data (numbers, mean, median, standard deviation, “P” values, 95% confidence intervals, effect sizes, relative risks, odds ratio, etc.).[ 3 , 7 , 8 , 9 , 10 , 12 , 13 , 14 , 17 ]

Conclusions: The take-home message (the “so what” of the paper) and other significant/important findings should be stated here, considering the interpretation of the research question/hypothesis and results put together (without overinterpreting the findings) and may also include the author's views on the implications of the study.[ 3 , 7 , 8 , 9 , 10 , 12 , 13 , 14 , 17 ]

The eight-point structured abstract: This has the following eight subheadings – Objectives, Study Design, Study Setting, Participants/Patients, Methods/Intervention, Outcome Measures, Results, and Conclusions.[ 3 , 9 , 18 ] The instructions to authors given by the particular journal state whether they use the four- or eight-point abstract or variants thereof.[ 3 , 14 ]

Descriptive and Informative abstracts

Descriptive abstracts are short (75–150 words), only portray what the paper contains without providing any more details; the reader has to read the full paper to know about its contents and are rarely used for original research papers.[ 7 , 10 ] These are used for case reports, reviews, opinions, and so on.[ 7 , 10 ] Informative abstracts (which may be structured or unstructured as described above) give a complete detailed summary of the article contents and truly reflect the actual research done.[ 7 , 10 ]

Drafting a suitable abstract

It is important to religiously stick to the instructions to authors (format, word limit, font size/style, and subheadings) provided by the journal for which the abstract and the paper are being written.[ 7 , 8 , 9 , 10 , 13 ] Most journals allow 200–300 words for formulating the abstract and it is wise to restrict oneself to this word limit.[ 1 , 2 , 3 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 22 ] Though some authors prefer to draft the abstract initially, followed by the main text of the paper, it is recommended to draft the abstract in the end to maintain accuracy and conformity with the main text of the paper (thus maintaining an easy linkage/alignment with title, on one hand, and the introduction section of the main text, on the other hand).[ 2 , 7 , 9 , 10 , 11 ] The authors should check the subheadings (of the structured abstract) permitted by the target journal, use phrases rather than sentences to draft the content of the abstract, and avoid passive voice.[ 1 , 7 , 9 , 12 ] Next, the authors need to get rid of redundant words and edit the abstract (extensively) to the correct word count permitted (every word in the abstract “counts”!).[ 7 , 8 , 9 , 10 , 13 ] It is important to ensure that the key message, focus, and novelty of the paper are not compromised; the rationale of the study and the basis of the conclusions are clear; and that the abstract is consistent with the main text of the paper.[ 1 , 2 , 3 , 7 , 9 , 11 , 12 , 13 , 14 , 17 , 22 ] This is especially important while submitting a revision of the paper (modified after addressing the reviewer's comments), as the changes made in the main (revised) text of the paper need to be reflected in the (revised) abstract as well.[ 2 , 10 , 12 , 14 , 22 ] Abbreviations should be avoided in an abstract, unless they are conventionally accepted or standard; references, tables, or figures should not be cited in the abstract.[ 7 , 9 , 10 , 11 , 13 ] It may be worthwhile not to rush with the abstract and to get an opinion by an impartial colleague on the content of the abstract; and if possible, the full paper (an “informal” peer-review).[ 1 , 7 , 8 , 9 , 11 , 17 ] Appropriate “Keywords” (three to ten words or phrases) should follow the abstract and should be preferably chosen from the Medical Subject Headings (MeSH) list of the U.S. National Library of Medicine ( https://meshb.nlm.nih.gov/search ) and are used for indexing purposes.[ 2 , 3 , 11 , 12 ] These keywords need to be different from the words in the main title (the title words are automatically used for indexing the article) and can be variants of the terms/phrases used in the title, or words from the abstract and the main text.[ 3 , 12 ] The ICMJE (International Committee of Medical Journal Editors; http://www.icmje.org/ ) also recommends publishing the clinical trial registration number at the end of the abstract.[ 7 , 14 ]

Checklist for a good abstract

Table 3 gives a checklist/useful tips for formulating a good abstract for a research paper.[ 1 , 2 , 3 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 17 , 22 ]

Checklist/useful tips for formulating a good abstract for a research paper

Concluding Remarks

This review article has given a detailed account of the importance and types of titles and abstracts. It has also attempted to give useful hints for drafting an appropriate title and a complete abstract for a research paper. It is hoped that this review will help the authors in their career in medical writing.

Financial support and sponsorship

Conflicts of interest.

There are no conflicts of interest.

Acknowledgement

The author thanks Dr. Hemant Deshmukh - Dean, Seth G.S. Medical College & KEM Hospital, for granting permission to publish this manuscript.

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The title summarizes the main idea or ideas of your study. A good title contains the fewest possible words needed to adequately describe the content and/or purpose of your research paper.

Importance of Choosing a Good Title

The title is the part of a paper that is read the most, and it is usually read first . It is, therefore, the most important element that defines the research study. With this in mind, avoid the following when creating a title:

• If the title is too long, this usually indicates there are too many unnecessary words. Avoid language, such as, "A Study to Investigate the...," or "An Examination of the...." These phrases are obvious and generally superfluous unless they are necessary to covey the scope, intent, or type of a study.
• On the other hand, a title which is too short often uses words which are too broad and, thus, does not tell the reader what is being studied. For example, a paper with the title, "African Politics" is so non-specific the title could be the title of a book and so ambiguous that it could refer to anything associated with politics in Africa. A good title should provide information about the focus and/or scope of your research study.
• In academic writing, catchy phrases or non-specific language may be used, but only if it's within the context of the study [e.g., "Fair and Impartial Jury--Catch as Catch Can"]. However, in most cases, you should avoid including words or phrases that do not help the reader understand the purpose of your paper.
• Academic writing is a serious and deliberate endeavor. Avoid using humorous or clever journalistic styles of phrasing when creating the title to your paper. Journalistic headlines often use emotional adjectives [e.g., incredible, amazing, effortless] to highlight a problem experienced by the reader or use "trigger words" or interrogative words like how, what, when, or why to persuade people to read the article or click on a link. These approaches are viewed as counter-productive in academic writing. A reader does not need clever or humorous titles to catch their attention because the act of reading research is assumed to be deliberate based on a desire to learn and improve understanding of the problem. In addition, a humorous title can merely detract from the seriousness and authority of your research. 
• Unlike everywhere else in a college-level social sciences research paper [except when using direct quotes in the text], titles do not have to adhere to rigid grammatical or stylistic standards. For example, it could be appropriate to begin a title with a coordinating conjunction [i.e., and, but, or, nor, for, so, yet] if it makes sense to do so and does not detract from the purpose of the study [e.g., "Yet Another Look at Mutual Fund Tournaments"] or beginning the title with an inflected form of a verb such as those ending in -ing [e.g., "Assessing the Political Landscape: Structure, Cognition, and Power in Organizations"].

Appiah, Kingsley Richard et al. “Structural Organisation of Research Article Titles: A Comparative Study of Titles of Business, Gynaecology and Law.” Advances in Language and Literary Studies 10 (2019); Hartley James. “To Attract or to Inform: What are Titles for?” Journal of Technical Writing and Communication 35 (2005): 203-213; Jaakkola, Maarit. “Journalistic Writing and Style.” In Oxford Research Encyclopedia of Communication . Jon F. Nussbaum, editor. (New York: Oxford University Press, 2018): https://oxfordre.com/communication.

Structure and Writing Style

The following parameters can be used to help you formulate a suitable research paper title:

• The purpose of the research
• The scope of the research
• The narrative tone of the paper [typically defined by the type of the research]
• The methods used to study the problem

The initial aim of a title is to capture the reader’s attention and to highlight the research problem under investigation.

Create a Working Title Typically, the final title you submit to your professor is created after the research is complete so that the title accurately captures what has been done . The working title should be developed early in the research process because it can help anchor the focus of the study in much the same way the research problem does. Referring back to the working title can help you reorient yourself back to the main purpose of the study if you find yourself drifting off on a tangent while writing. The Final Title Effective titles in research papers have several characteristics that reflect general principles of academic writing.

• Indicate accurately the subject and scope of the study,
• Rarely use abbreviations or acronyms unless they are commonly known,
• Use words that create a positive impression and stimulate reader interest,
• Use current nomenclature from the field of study,
• Identify key variables, both dependent and independent,
• Reveal how the paper will be organized,
• Suggest a relationship between variables which supports the major hypothesis,
• Is limited to 5 to 15 substantive words,
• Does not include redundant phrasing, such as, "A Study of," "An Analysis of" or similar constructions,
• Takes the form of a question or declarative statement,
• If you use a quote as part of the title, the source of the quote is cited [usually using an asterisk and footnote],
• Use correct grammar and capitalization with all first words and last words capitalized, including the first word of a subtitle. All nouns, pronouns, verbs, adjectives, and adverbs that appear between the first and last words of the title are also capitalized, and
• Rarely uses an exclamation mark at the end of the title.

The Subtitle Subtitles are frequently used in social sciences research papers because it helps the reader understand the scope of the study in relation to how it was designed to address the research problem. Think about what type of subtitle listed below reflects the overall approach to your study and whether you believe a subtitle is needed to emphasize the investigative parameters of your research.

1.  Explains or provides additional context , e.g., "Linguistic Ethnography and the Study of Welfare Institutions as a Flow of Social Practices: The Case of Residential Child Care Institutions as Paradoxical Institutions." [Palomares, Manuel and David Poveda.  Text & Talk: An Interdisciplinary Journal of Language, Discourse and Communication Studies 30 (January 2010): 193-212]

2.  Adds substance to a literary, provocative, or imaginative title or quote , e.g., "Listen to What I Say, Not How I Vote": Congressional Support for the President in Washington and at Home." [Grose, Christian R. and Keesha M. Middlemass. Social Science Quarterly 91 (March 2010): 143-167]

3.  Qualifies the geographic scope of the research , e.g., "The Geopolitics of the Eastern Border of the European Union: The Case of Romania-Moldova-Ukraine." [Marcu, Silvia. Geopolitics 14 (August 2009): 409-432]

4.  Qualifies the temporal scope of the research , e.g., "A Comparison of the Progressive Era and the Depression Years: Societal Influences on Predictions of the Future of the Library, 1895-1940." [Grossman, Hal B. Libraries & the Cultural Record 46 (2011): 102-128]

5.  Focuses on investigating the ideas, theories, or work of a particular individual , e.g., "A Deliberative Conception of Politics: How Francesco Saverio Merlino Related Anarchy and Democracy." [La Torre, Massimo. Sociologia del Diritto 28 (January 2001): 75 - 98]

6.  Identifies the methodology used , e.g. "Student Activism of the 1960s Revisited: A Multivariate Analysis Research Note." [Aron, William S. Social Forces 52 (March 1974): 408-414]

7.  Defines the overarching technique for analyzing the research problem , e.g., "Explaining Territorial Change in Federal Democracies: A Comparative Historical Institutionalist Approach." [ Tillin, Louise. Political Studies 63 (August 2015): 626-641.

With these examples in mind, think about what type of subtitle reflects the overall approach to your study. This will help the reader understand the scope of the study in relation to how it was designed to address the research problem.

Anstey, A. “Writing Style: What's in a Title?” British Journal of Dermatology 170 (May 2014): 1003-1004; Balch, Tucker. How to Compose a Title for Your Research Paper. Augmented Trader blog. School of Interactive Computing, Georgia Tech University; Bavdekar, Sandeep B. “Formulating the Right Title for a Research Article.” Journal of Association of Physicians of India 64 (February 2016); Choosing the Proper Research Paper Titles. AplusReports.com, 2007-2012; Eva, Kevin W. “Titles, Abstracts, and Authors.” In How to Write a Paper . George M. Hall, editor. 5th edition. (Oxford: John Wiley and Sons, 2013), pp. 33-41; Hartley James. “To Attract or to Inform: What are Titles for?” Journal of Technical Writing and Communication 35 (2005): 203-213; General Format. The Writing Lab and The OWL. Purdue University; Kerkut G.A. “Choosing a Title for a Paper.” Comparative Biochemistry and Physiology Part A: Physiology 74 (1983): 1; “Tempting Titles.” In Stylish Academic Writing . Helen Sword, editor. (Cambridge, MA: Harvard University Press, 2012), pp. 63-75; Nundy, Samiran, et al. “How to Choose a Title?” In How to Practice Academic Medicine and Publish from Developing Countries? A Practical Guide . Edited by Samiran Nundy, Atul Kakar, and Zulfiqar A. Bhutta. (Springer Singapore, 2022), pp. 185-192.

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Writing Effective Research Paper Titles: Advice and Examples

Are you ready to submit your research paper for publication but haven't settled on a title yet? Do you have a title but aren't sure if it will be the right one for the journal editor or research database search engines? This article will help you fine tune or create an effective research paper title for your work.

Now that you have finished your research and analysis, and you're ready to take the final step before sending your work to journal editors and reviewers. The first thing journal editors and search engine results will see and show is your research paper title. Creating an effective research paper title is highly important to getting your paper in front of the right people. It is also going to be the only part of your paper that is available to everyone for free, and it will be what search engines use to index and show your work in search results. You therefore must design a clear and persuasive title that accurately represents your work.

When writing an effective research paper title, you want to ensure that the title includes all the relevant aspects of your work. Showcase those aspects in a way that entices the audience to read more. Be sure to use the nomenclature common in your field of study, because that will help your work show up in more search results and it will grab the attention of journal editors looking for articles that clearly represent the industry. If you are studying landslides, for example, you will want to include keywords relating to soil composition or grain size; if you are working on a study about organ transplants, then include the specific feature or procedure that affected successful transplants. Identify what parts of your research are going to interest your intended audience.

There are two key pieces of information that people will need to see in your paper title: the subject and the objective. Because you are already familiar with your study and its purpose, creating an effective research paper title is simply a matter of whittling down the words that describe the important aspects of your paper. The advice below will help you take steps to identify key areas of your research, organize the information, and trim it down to the right size for a title.

Develop a topic statement

To get started, consider a topic statement of your paper that includes the subject and scope of the study. The first step in building a topic statement is to ask yourself the following questions:

• What is your research paper about? "My paper is about gene therapy and how it can improve cognitive function in dementia patients."
• What was the subject of your study? "I used data from 40 dementia patients from 10 states in the US."
• What method did you use to perform your research? "I performed a randomized trial."
• What were the results? "My study showed that gene therapy improved cognitive function in those who received the treatment."

Once you have answered those questions (such as in the example answers above), make a list of the keywords you used. For this example, those keywords would include the following:

• gene therapy
• cognitive function
• 40 dementia patients
• improved cognitive function
• 10 states in the US
• randomized trial

Then, create your topic statement using those keywords. It might read something like this:

"This study is a randomized trial that investigates whether gene therapy improved cognitive function in 40 dementia patients from 10 states in the US. The results show improved cognitive function in those who received the treatment."

This statement has 36 words — too long for a title. However, it does contain the main required elements: the subject and the objective. It also includes a summary of the results, which can be used to increase the persuasive nature of the title. If you are writing this down on paper, it may be helpful to underline or circle the keywords you used in the statement, as this will help you visually see how the keywords work together in your statement.

Trim the statement

The next step is to remove all unnecessary words to create a working title. Unnecessary words include elements that make the sentences complete sentences. Also remove words that are not central to your study or that would not be used in a research database search.

" This study is a randomized trial that investigates whether gene therapy improved cognitive function in 40 dementia patients from 10 states in the US. The results show improved cognitive function in those who received the treatment ."

Next, take those words and move them around to form a new phrase. This may take a few tries to get it right, but it is worth the time.

"A randomized trial investigating whether gene therapy improved cognitive function in 40 dementia patients from 10 states in the US showed improved cognitive function."

This sample now has 24 words. We still need to get it down to the ideal 15 or fewer total words, with just the exact information journal editors will want. One way to do this is to use the keywords at the beginning and end of your title. Remove any irrelevant facts that other researchers will not be searching for. For example, the method you used is not usually the most searched-for keyword.

" A randomized trial investigating whether gene therapy improved cognitive function in 40 dementia patients from 10 states in the US showed improved cognitive function. "

The final result may be something like this:

"Investigating the impact of gene therapy on cognitive function in dementia patients"

The resulting title has 13 words, had the main action at the beginning, and the main subject of the study at the end. This is a good example of how to create an effective research paper title that will increase journal editors' and reviewers' interest, and it may even help your paper receive more citations down the road.

Main tips to remember

If you are working on your first research paper title, the process can seem intimidating. Even with the process outlined above, creating the best research paper title possible for your work can be difficult and time consuming. Be sure to set aside a good amount of time to developing your title so that you don't feel rushed. Some writers go through 20 or more iterations before they arrive at a title that achieves effectiveness, persuasiveness, and clarity of purpose all in one.

In addition to the above process, keep the following main tips in mind when writing an effective research paper title:

• Write your paper and abstract first, then work on your title. This will make the process much easier than trying to nail a title down without a full, finished paper to start from.
• Keep your title short! Do not include more than 15 words.
• Do not use a period at the end of your title.
• Be sure that the keywords you use truly represent the content of your paper.
• Do not use abbreviations in your title.
• Include all essential key terms from your paper. This ensures your paper will be indexed properly in research databases and search engines. If you are unsure of the best keywords to use, talk to an academic librarian at your institution. They can help you identify keyword and search trends in your research field.

Examples of research paper titles

The lists below illustrate what effective and ineffective research paper titles look like. Use these examples to help guide your research paper title.

Effective titles

• Nurses on the Move: A Quantitative Report on How Meditation Can Improve Nurse Performance
• Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy
• Landslide mapping techniques and their use in the assessment of the landslide hazard
• HLA compatibility and organ transplant survival: Collaborative Transplant Study

Ineffective titles

• Meditation Gurus
• The landslide story
• Landslide hazard and risk assessment
• Pharmacodynamics of oral ganciclovir and valganciclovir in solid organ transplant recipients

No matter what kind of field you are doing research in, you have the opportunity to create an amazing and effective research paper title that will engage your readers and get your paper in front of the journal editors and reviewers you want. By taking the time to go through the title development process, you will finish your work with a title that matches the work outlined in your research paper.

Header photo by Stokkete .

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Your title is the first thing anyone who reads your article is going to see, and for many it will be where they stop reading. Learn how to write a title that helps readers find your article, draws your audience in and sets the stage for your research!

How your title impacts the success of your article

Researchers are busy and there will always be more articles to read than time to read them.  Good titles help readers find your research, and decide whether to keep reading. Search engines use titles to retrieve relevant articles based on users’ keyword searches. Once readers find your article, they’ll use the title as the first filter to decide whether your research is what they’re looking for. A strong and specific title is the first step toward citations, inclusion in meta-analyses, and influencing your field. 

What to include in a title

Include the most important information that will signal to your target audience that they should keep reading.

Key information about the study design

Important keywords

What you discovered

Writing tips

Getting the title right can be more difficult than it seems, and researchers refine their writing skills throughout their career. Some journals even help editors to re-write their titles during the publication process! 

• Keep it concise and informative What’s appropriate for titles varies greatly across disciplines. Take a look at some articles published in your field, and check the journal guidelines for character limits. Aim for fewer than 12 words, and check for journal specific word limits.
• Write for your audience Consider who your primary audience is: are they specialists in your specific field, are they cross-disciplinary, are they non-specialists?
• Entice the reader Find a way to pique your readers’ interest, give them enough information to keep them reading.
• Incorporate important keywords Consider what about your article will be most interesting to your audience: Most readers come to an article from a search engine, so take some time and include the important ones in your title!
• Write in sentence case In scientific writing, titles are given in sentence case. Capitalize only the first word of the text, proper nouns, and genus names. See our examples below.

Don’t

• Write your title as a question In most cases, you shouldn’t need to frame your title as a question. You have the answers, you know what you found. Writing your title as a question might draw your readers in, but it’s more likely to put them off.
• Sensationalize your research Be honest with yourself about what you truly discovered. A sensationalized or dramatic title might make a few extra people read a bit further into your article, but you don’t want them disappointed when they get to the results.

Examples…

Format: Prevalence of [disease] in [population] in [location]

Example: Prevalence of tuberculosis in homeless women in San Francisco

Format: Risk factors for [condition] among [population] in [location]

Example: Risk factors for preterm births among low-income women in Mexico City

Format (systematic review/meta-analysis): Effectiveness of [treatment] for [disease] in [population] for [outcome] : A systematic review and meta-analysis

Example: Effectiveness of Hepatitis B treatment in HIV-infected adolescents in the prevention of liver disease: A systematic review and meta-analysis

Format (clinical trial): [Intervention] improved [symptoms] of [disease] in [population] : A randomized controlled clinical trial

Example: Using a sleep app lessened insomnia in post-menopausal women in southwest United States: A randomized controlled clinical trial

Format  (general molecular studies): Characterization/identification/evaluation of [molecule name] in/from [organism/tissue] (b y [specific biological methods] ) 

Example: Identification of putative Type-I sex pheromone biosynthesis-related genes expressed in the female pheromone gland of Streltzoviella insularis

Format  (general molecular studies): [specific methods/analysis] of organism/tissue reveal insights into [function/role] of [molecule name] in [biological process]  

Example: Transcriptome landscape of Rafflesia cantleyi floral buds reveals insights into the roles of transcription factors and phytohormones in flower development

Format  (software/method papers): [tool/method/software] for [what purpose] in [what research area]

Example: CRISPR-based tools for targeted transcriptional and epigenetic regulation in plants

Tip: How to edit your work

Editing is challenging, especially if you are acting as both a writer and an editor. Read our guidelines for advice on how to refine your work, including useful tips for setting your intentions, re-review, and consultation with colleagues.

• How to Write an Abstract
• How to Write Your Methods
• How to Report Statistics
• How to Write Discussions and Conclusions
• How to Edit Your Work

The contents of the Peer Review Center are also available as a live, interactive training session, complete with slides, talking points, and activities. …

The contents of the Writing Center are also available as a live, interactive training session, complete with slides, talking points, and activities. …

There’s a lot to consider when deciding where to submit your work. Learn how to choose a journal that will help your study reach its audience, while reflecting your values as a researcher…

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Title, Abstract and Keywords

The importance of titles.

The title of your manuscript is usually the first introduction readers (and reviewers) have to your work. Therefore, you must select a title that grabs attention, accurately describes the contents of your manuscript, and makes people want to read further.

An effective title should:

• Convey the  main topics  of the study
• Highlight the  importance  of the research
• Be  concise
• Attract  readers

Writing a good title for your manuscript can be challenging. First, list the topics covered by the manuscript. Try to put all of the topics together in the title using as few words as possible. A title that is too long will seem clumsy, annoy readers, and probably not meet journal requirements.

Does Vaccinating Children and Adolescents with Inactivated Influenza Virus Inhibit the Spread of Influenza in Unimmunized Residents of Rural Communities?

This title has too many unnecessary words.

Influenza Vaccination of Children: A Randomized Trial

This title doesn’t give enough information about what makes the manuscript interesting.

Effect of Child Influenza Vaccination on Infection Rates in Rural Communities: A Randomized Trial This is an effective title. It is short, easy to understand, and conveys the important aspects of the research.

Think about why your research will be of interest to other scientists. This should be related to the reason you decided to study the topic. If your title makes this clear, it will likely attract more readers to your manuscript. TIP: Write down a few possible titles, and then select the best to refine further. Ask your colleagues their opinion. Spending the time needed to do this will result in a better title.

Abstract and Keywords

The Abstract is:

• A  summary  of the content of the journal manuscript
• A time-saving  shortcut  for busy researchers
• A guide to the most important parts of your manuscript’s written content

Many readers will only read the Abstract of your manuscript. Therefore, it has to be able to  stand alone . In most cases the abstract is the only part of your article that appears in indexing databases such as Web of Science or PubMed and so will be the most accessed part of your article; making a good impression will encourage researchers to read your full paper.

A well written abstract can also help speed up the peer-review process. During peer review, referees are usually only sent the abstract when invited to review the paper. Therefore, the abstract needs to contain enough information about the paper to allow referees to make a judgement as to whether they have enough expertise to review the paper and be engaging enough for them to want to review it.

Your Abstract should answer these questions about your manuscript:

• What was done?
• Why did you do it?
• What did you find?
• Why are these findings useful and important?

Answering these questions lets readers know the most important points about your study, and helps them decide whether they want to read the rest of the paper. Make sure you follow the proper journal manuscript formatting guidelines when preparing your abstract.

TIP: Journals often set a maximum word count for Abstracts, often 250 words, and no citations. This is to ensure that the full Abstract appears in indexing services.

Keywords  are a tool to help indexers and search engines find relevant papers. If database search engines can find your journal manuscript, readers will be able to find it too. This will increase the number of people reading your manuscript, and likely lead to more citations.

However, to be effective, Keywords must be chosen carefully. They should:

• Represent  the content of your manuscript
• Be  specific  to your field or sub-field

Manuscript title:  Direct observation of nonlinear optics in an isolated carbon nanotube

Poor keywords:  molecule, optics, lasers, energy lifetime

Better keywords:  single-molecule interaction, Kerr effect, carbon nanotubes, energy level structure

Manuscript title:  Region-specific neuronal degeneration after okadaic acid administration Poor keywords:  neuron, brain, OA (an abbreviation), regional-specific neuronal degeneration, signaling

Better keywords:  neurodegenerative diseases; CA1 region, hippocampal; okadaic acid; neurotoxins; MAP kinase signaling system; cell death

Manuscript title:  Increases in levels of sediment transport at former glacial-interglacial transitions

Poor keywords:  climate change, erosion, plant effects Better keywords:  quaternary climate change, soil erosion, bioturbation

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Ever find it hard to come up with a catchy title for your research paper? You're not alone! Many people struggle with creating titles that grab attention and show what their work is about.

It can be frustrating because your title is like a first impression. If it's not interesting, people might ignore your research. 

But no worries! 

In this blog, we'll give you practical tips and examples to make sure your research paper title stands out. 

Whether you're a beginner or an expert, we want to help you write research paper titles that would make others excited about your work!

So, let’s get started.

• 1. What is a Research Paper Title, and Why Does it Matter?
• 2. How to Write a Good Research Paper Title in 5 Steps
• 3. Step 2: Keep it Clear and Concise
• 4. Research Paper Title Examples
• 5. Tips for Writing an Effective Research Paper Title

What is a Research Paper Title, and Why Does it Matter?

A research paper title is like the name tag for your work. It tells people what your research paper is about. It's the first thing readers see, and it's important because it helps them decide if they want to read more.

Think of it like this: Have you ever picked up a book because the title sounded interesting? It's kind of the same idea. A good title grabs attention and makes people curious about what's inside.

In the world of research, a well-crafted title is crucial because it sets the stage for your whole paper. 

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Key Characteristics of a Good Research Paper Title

Here are some important factors that create an engaging and interesting research paper title:

• Clarity and Precision: Clearly conveys the main idea.
• Relevance to Content: Reflects core focus and findings.
• Conciseness: Keeps title brief and to the point.
• Keywords and Phrases: Includes important search keywords.
• Captivating Language: Engages interest without sacrificing accuracy.
• Reflects Paper's Tone: Matches the research paper's tone and style.

How to Write a Good Research Paper Title in 5 Steps

Writing an effective research paper title doesn't have to be difficult. Follow these five straightforward steps to craft a title that not only reflects your research but also captures the reader's interest.

Step 1: Understand Your Paper's Main Message

Think of your research as a big idea or a story. Imagine it as the most important thing you want to share with others. 

Ask yourself: What's the main thing or research problem I want people to know about my research? 

Once you're clear on this, you're ready to move on.

Step 2: Keep it Clear and Concise

When making your title, make it short and simple. Don't use too many words or make it confusing. 

The goal is to make it easy for people to understand what your paper is about right away. Think of it like telling a quick and clear story with your title!

Step 3: Be Specific, Not Too General

When writing your title, make sure it talks about your research and not just anything general. Don't use titles that could fit lots of different studies. 

Being specific helps people know exactly what your paper is going to tell them. It's like giving them a clear roadmap to your research!

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Step 4: Inject a Hint of Creativity or Intrigue

Make your title a little exciting! Use engaging words or ask a fun question to make people curious. Imagine your title as a little mystery that makes them want to learn more

Step 5: Check for Keywords and Relevance

Think about the words people might use when searching for research like yours. Use those words in your title to help people find your work. 

Including relevant keywords can improve the visibility of your paper in searches.

Adding a Research Paper Subtitle

A research paper subtitle is like an extra description that comes after the main title. It gives more details about what your research is about. 

Adding a subtitle is a choice, but it can be helpful. If your main title is short and you want to say more about your research, a subtitle is a good idea. 

It's like a bonus that provides extra information for readers. Consider using a subtitle when you want to give a bit more insight into your research topic.

Research Paper Title Examples

Check out the examples below and see how they perform in front of different factors:

Tips for Writing an Effective Research Paper Title

Follow these tips to make your research paper title engaging and attention-grabbing:

• Add important words related to your research for better search results.
• Make your title brief and clear to convey your research focus effectively.
• Use words that grab attention and spark curiosity about your study.
• Craft a title that anyone, whether an expert or newcomer, can understand.
• Aim for a title that's not too general or too technical, striking the right balance.

In conclusion,

Writing a standout research paper title is a crucial step to ensure your work gets the attention it deserves. Following the simple tips shared in this guide can help you create a title that is clear, engaging, and perfectly aligned with your research focus. 

Remember, your title is the first thing readers see, so making it count is key!

However, if you need writing assistance, MyPerfectWords.com is here for you. Our skilled writers are not only ready to help with writing compelling titles but can also write custom research paper just for you.

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John K. is a professional writer and author with many publications to his name. He has a Ph.D. in the field of management sciences, making him an expert on the subject matter. John is highly sought after for his insights and knowledge, and he regularly delivers keynote speeches and conducts workshops on various topics related to writing and publishing. He is also a regular contributor to various online publications.

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Keep reading

1000+ FREE Research Topics & Title Ideas

If you’re at the start of your research journey and are trying to figure out which research topic you want to focus on, you’ve come to the right place. Select your area of interest below to view a comprehensive collection of potential research ideas.

Research Topic FAQs

What (exactly) is a research topic.

A research topic is the subject of a research project or study – for example, a dissertation or thesis. A research topic typically takes the form of a problem to be solved, or a question to be answered.

A good research topic should be specific enough to allow for focused research and analysis. For example, if you are interested in studying the effects of climate change on agriculture, your research topic could focus on how rising temperatures have impacted crop yields in certain regions over time.

To learn more about the basics of developing a research topic, consider our free research topic ideation webinar.

What constitutes a good research topic?

A strong research topic comprises three important qualities : originality, value and feasibility.

• Originality – a good topic explores an original area or takes a novel angle on an existing area of study.
• Value – a strong research topic provides value and makes a contribution, either academically or practically.
• Feasibility – a good research topic needs to be practical and manageable, given the resource constraints you face.

To learn more about what makes for a high-quality research topic, check out this post .

What's the difference between a research topic and research problem?

A research topic and a research problem are two distinct concepts that are often confused. A research topic is a broader label that indicates the focus of the study , while a research problem is an issue or gap in knowledge within the broader field that needs to be addressed.

To illustrate this distinction, consider a student who has chosen “teenage pregnancy in the United Kingdom” as their research topic. This research topic could encompass any number of issues related to teenage pregnancy such as causes, prevention strategies, health outcomes for mothers and babies, etc.

Within this broad category (the research topic) lies potential areas of inquiry that can be explored further – these become the research problems . For example:

• What factors contribute to higher rates of teenage pregnancy in certain communities?
• How do different types of parenting styles affect teen pregnancy rates?
• What interventions have been successful in reducing teenage pregnancies?

Simply put, a key difference between a research topic and a research problem is scope ; the research topic provides an umbrella under which multiple questions can be asked, while the research problem focuses on one specific question or set of questions within that larger context.

How can I find potential research topics for my project?

There are many steps involved in the process of finding and choosing a high-quality research topic for a dissertation or thesis. We cover these steps in detail in this video (also accessible below).

How can I find quality sources for my research topic?

Finding quality sources is an essential step in the topic ideation process. To do this, you should start by researching scholarly journals, books, and other academic publications related to your topic. These sources can provide reliable information on a wide range of topics. Additionally, they may contain data or statistics that can help support your argument or conclusions.

Identifying Relevant Sources

When searching for relevant sources, it’s important to look beyond just published material; try using online databases such as Google Scholar or JSTOR to find articles from reputable journals that have been peer-reviewed by experts in the field.

You can also use search engines like Google or Bing to locate websites with useful information about your topic. However, be sure to evaluate any website before citing it as a source—look for evidence of authorship (such as an “About Us” page) and make sure the content is up-to-date and accurate before relying on it.

Evaluating Sources

Once you’ve identified potential sources for your research project, take some time to evaluate them thoroughly before deciding which ones will best serve your purpose. Consider factors such as author credibility (are they an expert in their field?), publication date (is the source current?), objectivity (does the author present both sides of an issue?) and relevance (how closely does this source relate to my specific topic?).

By researching the current literature on your topic, you can identify potential sources that will help to provide quality information. Once you’ve identified these sources, it’s time to look for a gap in the research and determine what new knowledge could be gained from further study.

How can I find a good research gap?

Finding a strong gap in the literature is an essential step when looking for potential research topics. We explain what research gaps are and how to find them in this post.

How should I evaluate potential research topics/ideas?

When evaluating potential research topics, it is important to consider the factors that make for a strong topic (we discussed these earlier). Specifically:

• Originality
• Feasibility

So, when you have a list of potential topics or ideas, assess each of them in terms of these three criteria. A good topic should take a unique angle, provide value (either to academia or practitioners), and be practical enough for you to pull off, given your limited resources.

Finally, you should also assess whether this project could lead to potential career opportunities such as internships or job offers down the line. Make sure that you are researching something that is relevant enough so that it can benefit your professional development in some way. Additionally, consider how each research topic aligns with your career goals and interests; researching something that you are passionate about can help keep motivation high throughout the process.

How can I assess the feasibility of a research topic?

When evaluating the feasibility and practicality of a research topic, it is important to consider several factors.

First, you should assess whether or not the research topic is within your area of competence. Of course, when you start out, you are not expected to be the world’s leading expert, but do should at least have some foundational knowledge.

Time commitment

When considering a research topic, you should think about how much time will be required for completion. Depending on your field of study, some topics may require more time than others due to their complexity or scope.

Additionally, if you plan on collaborating with other researchers or institutions in order to complete your project, additional considerations must be taken into account such as coordinating schedules and ensuring that all parties involved have adequate resources available.

Resources needed

It’s also critically important to consider what type of resources are necessary in order to conduct the research successfully. This includes physical materials such as lab equipment and chemicals but can also include intangible items like access to certain databases or software programs which may be necessary depending on the nature of your work. Additionally, if there are costs associated with obtaining these materials then this must also be factored into your evaluation process.

Potential risks

It’s important to consider the inherent potential risks for each potential research topic. These can include ethical risks (challenges getting ethical approval), data risks (not being able to access the data you’ll need), technical risks relating to the equipment you’ll use and funding risks (not securing the necessary financial back to undertake the research).

If you’re looking for more information about how to find, evaluate and select research topics for your dissertation or thesis, check out our free webinar here . Alternatively, if you’d like 1:1 help with the topic ideation process, consider our private coaching services .

Psst... there’s more!

This post was based on one of our popular Research Bootcamps . If you're working on a research project, you'll definitely want to check this out ...

6 tips for writing a great title for your research article

Title is the first thing the reader sees from your research article. Based on the title the reader decides to have a look at the article — or not. So a better title will attract more readers and quite possibly increase the impact of your research. If you wonder what makes a good title, and how you can formulate one for your paper as well, then check out our six tips for writing a great research article title.

Goal: catch the attention of the *right* reader

A good title helps the reader quickly recognize whether this paper is relevant for them. The title should give the reader an accurate picture of the article — and motivate the *right* reader to go on and read the article.

Additionally, an ideal title is memorable : researchers are reading many papers, some will be inevitably forgotten. A good title ensures that your paper will stick in your reader’s mind.

Case study: Important paper missed because of its title

Let me tell you an example from my own research, about an important paper that we missed because of its title.

Article entitled Distinct contributions of Na V 1.6 and Na V 1.2 in action potential initiation and backpropagation has been published in July 2009 in the prestigious journal Nature Neuroscience .

A couple of months later I started to work on a project that later became my PhD thesis. And the above mentioned article turned out to be the most important study on which my whole work was based.

Yet when I started, I didn’t know about the paper. My supervisor and another professor working on similar topics didn’t know about it either.

They had surely seen the title since they were following the journal’s publications. But they didn’t recognize that this might be a relevant paper.

Eventually we learned about the paper from a collaborator from a different institute. Later when I was presenting my work at conferences, I encountered many other researchers who missed this paper, even though it was clearly relevant to them.

So, what’s the issue with this title? Read on my tips on how to write a great title , and learn along the way what is problematic with this title and how we can fix it.

1. Headline the main result, not the main effort

If your paper has a clear main finding that can be summarized in a sentence , put it in the title. Such a title is much more interesting (and informative) than a title describing your approach.

Prof. Kevin Plaxco gives the following examples in his commentary article The art of writing science :

• Main effort (not optimal): A phylogenetic analysis of humans and chimps
• Main result (preferred): Phylogenetic evidence indicates an exceptionally close relationship between humans and chimps

Here is another example:

• Main result missing: Cognitive-behavioural stress management skills and quality of life in stress-related disorders
• Main result in the title: Cognitive-behavioural stress management skills improve quality of life in stress-related disorders

Concerning our case study example, the title Distinct contributions of Na V 1.6 and Na V 1.2 in action potential initiation and backpropagation does (kind of) contain the main result, albeit it is not formulated as a full sentence. We’ll see later how we can improve it.

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Click here for an efficient step-by-step revision of your scientific texts.

2. Adapt the level of detail to your target audience

If your article is intended for a broader audience (that is, you want to publish it in a general journal), your title should be more general , so that it is understandable to this broader audience.

On the other hand, if your article is intended for a specialized audience and a specialized journal, you can include more details and jargon in the title.

• article published in the broad journal Nature: The hippocampus is crucial for forming non-hippocampal long-term memory during sleep
• article on a similar topic published in the specialized journal Neurobiology of Learning and Memory: Sleep enhances memory consolidation in the hippocampus-dependent object-place recognition task in rats

However, be careful with short and general titles . Such titles are typical for review articles , because they suggest a broad scope of the article. So your readers might mistaken your original research article for a review article.

For example, the title Axon Initial Segment–Associated Microglia sounds like it’s a review, but it is an original research article. Such a title is misleading for the readers, so it’s better to avoid it.

Not every neuroscientist knows what is “Na V 1.6″ and “Na V 1.2″. My supervisor didn’t know either — and it turns out that this was one of the reasons why he and the other professor missed this article. “Na V 1.6″ and “Na V 1.2″ are sodium channels — and every neuroscientist knows what are those. So the keyword “sodium channels” should definitely be included in an article title published in such a general journal as Nature Neuroscience .

3. Avoid “fluff” at the beginning of the title

Beginning of the title is especially salient , especially visible to the reader. And often this is your only chance to convince your potential reader that this paper is relevant to them.

So it’s a mistake to start the title with “fluff”, that is, a phrase that doesn’t carry much content and can be safely omitted. Instead, begin your title with an important keyword .

For example:

• Aspects of ​immune dysfunction in end-stage renal disease
• Revisiting the role of xanthophylls in nonphotochemical quenching

Our case-study title Distinct contributions of Na V 1.6 and Na V 1.2 in action potential initiation and backpropagation does not start with a meaningless phrase that can be simply deleted. However, it also doesn’t start with an important keyword. Let’s see in the next point what would be a better beginning of the title.

4. Use the Context – Emphasis structure

A great title follows the optimal sentence structure : The beginning of the title acts as context for the rest of the title while the end of the title is naturally emphasized (if the reader gets this far).

So a good strategy is to include at the beginning of the title a keyword that will be recognized by all of your target readers and at the end of the title a keyword that is specific to your paper and its contribution.

However, what is a general keyword and what is a specific contribution might depend on your audience .

For example, the title Selective Adsorption to Particular Crystal Faces of ZnO suggests that this article primarily targets researchers interested in adsorption processes: “selective adsorption” is the general process, which is examined in this paper for the particular case of ZnO. However, if the paper targets researchers working on ZnO (zinc oxide), then it would be better to mention “ZnO” at beginning of the title.

Now let’s consider our case study : Distinct contributions of Na V 1.6 and Na V 1.2 in action potential initiation and backpropagation .

Then, what is a specific keyword related to the contribution of this paper? I would say it could be “Na V 1.6 and Na V 1.2 sodium channels”: although there are some previous studies investigating these two channel types, this paper put all the puzzle pieces together and provided a coherent picture about the interplay of these two channel types in — you guessed it — action potential initiation and backpropagation.

So, let’s improve this title by putting “Action potential initiation and backpropagation” at the beginning and “Na V 1.6 and Na V 1.2 sodium channels” at the end. Then we can rearrange the rest such that it makes sense — and reveals the main message of the paper:

Action potential initiation and backpropagation is differentially regulated by Na V 1.6 and Na V 1.2 sodium channels

A much better title, don’t you think?

5. “Context: Details” structure also works

But what to do with papers that have no single take-home message that can be summarized in a sentence?

For explorative papers that cover several problems or aspects of a topic, the “Context: Details” structure is often suitable. Here, you start with the general contextual keyword(s) that grab the attention of the reader, and then supplement relevant details after the colon.

• UCB revisited: Improved regret bounds for the stochastic multi-armed bandit problem
• Single Cell Assay for Molecular Diagnostics and Medicine: Monitoring Intracellular Concentrations of Macromolecules by Two-photon Fluorescence Lifetime Imaging

Here are some examples that don’t work very well:

• Noise statistics identification for Kalman filtering of the electron radiation belt observations: 2. Filtration and smoothing
• A better oscillation detection method robustly extracts EEG rhythms across brain state changes: The human alpha rhythm as a test case

In these cases, the first part before the colon is too long, it provides much more information than just the context, and therefore the whole title becomes harder to understand and remember.

So for an effective “Context: Details” type of title, make sure that the first part before the colon is short and memorable . Then the second part after the colon can be longer and detailed, and the title will still create a clear image in reader’s mind.

6. Title as a question or catchy title? It depends…

Now you might ask yourself: can’t we write more interesting titles than those that accurately reflect the content of the paper? These can be pretty boring… What about titles formulated as questions? And “catchy” titles?

Well, the general rule is to follow the conventions of your field . If some of the research articles you are reading have catchy titles, then it’s most probably OK for you to do this as well.

For example, questions and catchy titles are quite common in research articles from psychology:

• How often is p rep close to the true replication probability?
• Must interesting things be pleasant? A test of competing appraisal structures.

On the other hand, I have rarely seen a question as a title in a research article from neuroscience.

However, in most fields catchy and even funny titles are appreciated in commentary and opinion articles . For example, the “news & views” commentary article introducing our case-study paper Distinct contributions of Na V 1.6 and Na V 1.2 in action potential initiation and backpropagation is entitled Who let the spikes out?

Also the titles of review articles might be less formal. Which brings us to the next point…

Titles of review articles

Titles of review articles tend to be more general and broad than titles of original research articles. This, of course, reflects the broader scope and content of review articles. For example:

• Carbohydrate inhibitors of cholera toxin
• Neural circuits underlying thirst and fluid homeostasis

These titles don’t consist of a full sentence — because there is rarely a main take-home message in a review article. However, what is helpful here is to follow the Context-Emphasis structure introduced in point 4.

Titles of review articles often include the word “review” in the title, for example:

• Gap junctions in developing neocortex: a review
• A systematic review of COVID-19 epidemiology based on current evidence

And as we said in the previous point, titles of review articles may be less formal and more catchy even in fields where such titles are not used for original research articles:

• Spooky sodium balance
• Remembering the past to imagine the future: the prospective brain

How to find the perfect title for your article

Now you have learned all the rules for good titles, but one question remains: How to proceed? How to come up with a great title for your article?

Then I recommend the following procedure :

• First, generate 10 possible titles . These 10 titles don’t have to be unique: some of them might only differ in one or two words or in the word order.
• Next, select the best title . You can do this together with your co-authors. Or each co-author picks one or two favorites and then you discuss and select the final title together.

With this procedure it’s much easier to find the most suitable title for your paper than if you would create just one title and then try to improve it.

So that was quite some theory about how to write a great title. Now if you want to practice this new knowledge, here is a little exercise for you.

What is good and what is not optimal about these titles? How would you improve them?

• Analysis of processes leading to localized electron enhancements in the outer radiation belt
• Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramers
• A New Murine Model to Define the Critical Pathologic and Therapeutic Mediators of Polymyositis

If you are currently writing a manuscript and would like to get feedback and suggestions for your title: please, feel free to post it as a comment . Alternatively, you can also ask for feedback in our Facebook group Academic writing — peer feedback .

Do you need to revise & polish your manuscript or thesis but don’t know where to begin? Is your text a mess and you don't know how to improve it?

Click here for an efficient step-by-step revision of your scientific texts. You will be guided through each step with concrete tips for execution.

3 thoughts on “ 6 tips for writing a great title for your research article ”

Dear Martina,

Thank you very much for another portion of valuable information! It’s really helpful!

I’d be very greatful if you could comment on a title for a review article I’m writting now. Which of the two title you think is better:

Novel approaches to epigenetic therapies Novel approaches to epigenetic therapies: from drug combinations to epigenetic editing

Thank you for your suggestion, Kind regards, Aleksandra

Dear Aleksandra,

I am happy to hear that you found the article helpful!

Concerning your question: I prefer the second, longer title. It gives the reader a much better idea of what your review article is about. “Novel approaches to epigenetic therapies” alone is rather unspecific…

All the best, Martina

That was my choice as well! Thank you for ensuring me about it!

All the best, Aleksandra

Comments are closed.

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5 Simple steps to write a good research paper title

Title, Abstract & keywords

Jayashree Rajagopalan

The first thing journal editors and reviewers will see upon receiving your research paper is the title, and will immediately form a view on what they should expect in your research paper. Moreover, the tile of your research paper is the only aspect that will be freely available to readers through search engines or indexing databases. It is therefore imperative that you write a clear, persuasive title that leads readers to know more about your research.

In a hurry? We have just the thing for you -- The following 3-minute interactive video will give you a quick summary of the 5 simple steps to follow while writing an effective research paper title. 

You can also go on to read the rest of the article to deepen your understanding of which best practices to follow while writing a captivating, yet informative title for your research paper. 

The following example will help you understand how you can go about writing a good title for your research paper in 5 simple steps:

Ask yourself these questions and make note of the answers:

• What is my paper about?

My paper studies whether X therapy improves the cognitive function of patients suffering from dementia.

• What techniques/ designs were used?

It was a randomized trial.

• Who/what is studied?

I studied 40 cases from six cities in Japan.

• What were the results?

There was an improvement in the cognitive function of patients.

Use your answers to list key words.

• Randomized trial
• 6 Japanese cities
• Improved cognitive function

Does your publication goal seem near yet too far?

Explore Researcher.Life to get the boost you need to achieve all your goals

Create a sentence that includes the key words you listed.

This study is a randomized trial that investigates whether X therapy improved cognitive function in 40 dementia patients from 6 cities in Japan; it reports improved cognitive function.

(Current length: 28 words)

Delete all unnecessary/ repetitive words and link the remaining. 

This study is a  randomized trial  that investigates whether  X therapy improved cognitive function in 40 dementia patients from 6 cities in Japan;  it reports improved cognitive function Randomized trial of X therapy for improving cognitive function in 40 dementia patients from 6 cities in Japan

(Length of revised title: 18 words)

Delete non-essential information and reword the title. 

Randomized trial  of  X therapy  for improving  cognitive function in 40 dementia patients  from 6 cities in Japan reports improved cognitive function

Randomized trial of X therapy for improving cognitive function in 40 dementia patients 

(Length of finalized title: 13 words) 

Include a subtitle

X therapy improves cognitive function in 40 dementia patients: A randomized trial 

(Title length: 12 words) Following the steps outlined above will help you arrive at an effective title for your research paper. Learn in depth how you can write a persuasive title for your manuscript with this course designed exclusively for researchers: How and how not to title your research paper - A handbook for authors

Related reading: The complete guide to writing a brilliant research paper

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Published on: Nov 18, 2014

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Organizing Academic Research Papers: Choosing a Title

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The title summarizes the main idea or ideas of your study. A good title contains the fewest possible words that adequately describe the contents and/or purpose of your research paper.

The title is without doubt the part of a paper that is read the most, and it is usually read first . If the title is too long it usually contains too many unnecessary words, e.g., "A Study to Investigate the...." On the other hand, a title which is too short often uses words which are too general. For example, "African Politics" could be the title of a book, but it does not provide any information on the focus of a research paper.

Structure and Writing Style

The following parameters can be used to help you formulate a suitable research paper title:

• The purpose of the research
• The narrative tone of the paper [typically defined by the type of the research]
• The methods used

The initial aim of a title is to capture the reader’s attention and to draw his or her attention to the research problem being investigated.

Create a Working Title Typically, the final title you submit to your professor is created after the research is complete so that the title accurately captures what was done . The working title should be developed early in the research process because it can help anchor the focus of the study in much the same way the research problem does. Referring back to the working title can help you reorient yourself back to the main purpose of the study if you feel yourself drifting off on a tangent while writing. The Final Title Effective titles in academic research papers have several characteristics.

• Indicate accurately the subject and scope of the study.
• Avoid using abbreviations.
• Use words that create a positive impression and stimulate reader interest.
• Use current nomenclature from the field of study.
• Identify key variables, both dependent and independent.
• May reveal how the paper will be organized.
• Suggest a relationship between variables which supports the major hypothesis.
• Is limited to 10 to 15 substantive words.
• Do not include "study of," "analysis of" or similar constructions.
• Titles are usually in the form of a phrase, but can also be in the form of a question.
• Use correct grammar and capitalization with all first words and last words capitalized, including the first word of a subtitle. All nouns,  pronouns, verbs, adjectives, and adverbs that appear between the first and last words of the title are also capitalized.
• In academic papers, rarely is a title followed by an exclamation mark. However, a title or subtitle can be in the form of a question.

The Subtitle Subtitles are quite common in social science research papers. Examples of why you may include a subtitle:

• Explains or provides additional context , e.g., "Linguistic Ethnography and the Study of Welfare Institutions as a Flow of Social Practices: The Case of Residential Child Care Institutions as Paradoxical Institutions."
• Adds substance to a literary, provocative, or imaginative title , e.g., "Listen to What I Say, Not How I Vote: Congressional Support for the President in Washington and at Home."
• Qualifies the geographic scope of the research , e.g., "The Geopolitics of the Eastern Border of the European Union: The Case of Romania-Moldova-Ukraine."
• Qualifies the temporal scope of the research , e.g., "A Comparison of the Progressive Era and the Depression Years: Societal Influences on Predictions of the Future of the Library, 1895-1940."
• Focuses on investigating the ideas, theories, or work of a particular individual , e.g., "A Deliberative Conception of Politics: How Francesco Saverio Merlino Related Anarchy and Democracy."

Balch, Tucker. How to Compose a Title for Your Research Paper . Augmented Trader blog. School of Interactive Computing, Georgia Tech University;  Choosing the Proper Research Paper Titles . AplusReports.com, 2007-2012; General Format. The Writing Lab and The OWL. Purdue University.

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80+ Great Research Titles Examples in Various Academic Fields

Coming up with a research title for an academic paper is one of the most challenging parts of the writing process. Even though there is an unlimited quantity of research titles to write about, knowing which one is best for you can be hard. We have done the research for you and compiled eighty examples of research titles to write on. Additionally, we have divided the research titles examples into sections to make them easier to choose.

Research Study Examples of Current Events

Examples of research topics on ethics, title of research study examples on health, research paper title examples on social concerns, examples of research title on art and culture, example of research interest in religion, samples of research study topics on technology, research examples of environmental studies, good research title examples on history, specific topic examples regarding education, research title examples for students on family, food, and nutrition, research problems examples computer science, samples of research title about business marketing and communications, sample of research study topics in women’s studies, research problem example on politics, what are some examples of research paper topics on law, final words about research titles.

When it comes to choosing a good sample research title, research is one of the best tips you can get. By reading widely, including your school notes and scholarly articles, you will have a problem/line of interest examples in research. Then, you can derive any question from areas that appear to have a knowledge gap and proceed with researching the answer. As promised, below are eighty research title examples categorized into different areas, including social media research topics .

• Discuss the peculiar policies of a named country – for example, discuss the impacts of the one-child policy of China.
• Research on the influence of a named political leader, say a president, on the country they governed and other countries around. For instance, you can talk about how Trump’s presidency has changed international relations.
• Conduct an analysis of a particular aspect of two named countries – for example, the history of the relationship between the U.S. and North Korea.
• Compare the immigration laws in two or more named countries – for example, discuss how the immigration laws in the U.S. compares with other countries.
• Discuss how the Black Lives Matter movement has affected the view and discussions about racism in the United States.
• Enumerate the different ways the government of the United States can reduce deaths arising from the unregulated use of guns.
• Analyze the place of ethics in medicine or of medical practitioners. For instance, you can discuss the prevalence of physician-assisted suicides in a named country. You may also talk about the ethicality of such a practice and whether it should be legal.
• Explain how recent research breakthroughs have affected that particular field – for instance, how stem cell research has impacted the medical field.
• Explain if and why people should be able to donate organs in exchange for money.
• Discuss ethical behaviors in the workplace and (or) the educational sector. For example, talk about whether or not affirmative action is still important or necessary in education or the workplace.
• Weigh the benefits and risks of vaccinating children and decide which one outweighs the other. Here, you might want to consider the different types of vaccinations and the nature and frequency of associated complications.
• Investigate at least one of the health issues that currently pose a threat to humanity and which are under investigation. These issues can include Alzheimer’s, cancer, depression, autism, and HIV/AIDS. Research how these issues affect individuals and society and recommend solutions to alleviate cost and suffering.
• Study some individuals suffering from and under treatment for depression. Then, investigate the common predictors of the disease and how this information can help prevent the issue.

Tip : To make this example of a research title more comprehensive, you can focus on a certain age range – say, teenagers.

• Discuss whether or not free healthcare and medication should be available to people and the likely implications.
• Identify and elucidate different methods or programs that have been most effective in preventing or reducing teen pregnancy.
• Analyze different reasons and circumstances for genetic manipulation and the different perspectives of people on this matter. Then, discuss whether or not parents should be allowed to engineer designer babies.
• Identify the types of immigration benefits, including financial, medical, and education, your country provides for refugees and immigrants. Then, discuss how these benefits have helped them in settling down and whether more or less should be provided.
• Discuss the acceptance rate of the gay community in your country or a specific community. For example, consider whether or not gay marriage is permitted if they can adopt children, and if they are welcome in religious gatherings.
• Explore and discuss if terrorism truly creates a fear culture that can become a society’s unintended terrorist.
• Consider and discuss the different techniques one can use to identify pedophiles on social media.

Tip : Social issues research topics are interesting, but ensure you write formally and professionally.

• Investigate the importance or lack of importance of art in primary or secondary education. You can also recommend whether or not it should be included in the curriculum and why.

Tip : You can write on this possible research title based on your experiences, whether positive or negative.

• Discuss the role of illustration in children’s books and how it facilitates easy understanding in children. You may focus on one particular book or select a few examples and compare and contrast.
• Should the use of art in books for adults be considered, and what are the likely benefits?
• Compare and contrast the differences in art from two named cultural Renaissance – for instance, the Northern Renaissance and the Italian Renaissance.
• Investigate how sexism is portrayed in different types of media, including video games, music, and film. You can also talk about whether or not the amount of sexism portrayed has reduced or increased over the years.
• Explore different perspectives and views on dreams; are they meaningful or simply a game of the sleeping mind? You can also discuss the functions and causes of dreams, like sleeping with anxiety, eating before bed, and prophecies.
• Investigate the main reasons why religious cults are powerful and appealing to the masses, referring to individual cases.
• Investigate the impact of religion on the crime rate in a particular region.

Tip : Narrow down this research title by choosing to focus on a particular age group, say children or teenagers, or family. Alternatively, you can focus on a particular crime in the research to make the paper more extensive.

• Explore reasons why Martin Luther decided to split with the Catholic church.
• Discuss the circumstances in Siddhartha’s life that led to him becoming the Buddha.

Tip : It is important to remove sentiments from your research and base your points instead on clear evidence from a sound study. This ensures your title of research does not lead to unsubstantiated value judgments, which reduces the quality of the paper.

• Discuss how the steel sword, gunpowder, biological warfare, longbow, or atomic bomb has changed the nature of warfare.

Tip : For this example of the research problem, choose only one of these technological developments or compare two or more to have a rich research paper.

• Explore the changes computers, tablets, and smartphones have brought to human behaviors and culture, using published information and personal experience.

Tip : Approach each research study example in a research paper context or buy research paper online , giving a formal but objective view of the subject.

• Are railroads and trains primary forces in the industrialization, exploitation, and settlement of your homeland or continent?
• Discuss how the use of fossil fuels has changed or shaped the world.

Tip : Narrow down this title of the research study to focus on a local or particular area or one effect of fossil fuels, like oil spill pollution.

• Discuss what progress countries have made with artificial intelligence. You can focus on one named country or compare the progress of one country with another.
• Investigate the factual status of global warming – that is, is it a reality or a hoax? If it is a reality, explore the primary causes and how humanity can make a difference.
• Conduct in-depth research on endangered wildlife species in your community and discuss why they have become endangered. You can also enumerate what steps the community can take to prevent these species from going extinct and increase their chances of survival.
• Investigate the environmental soundness of the power sources in your country or community. Then, recommend alternative energy sources that might be best suited for the area and why.
• Consider an area close to wildlife reserves and national parks, and see whether oil and mineral exploration has occurred there. Discuss whether this action should be allowed or not, with fact-backed reasons.
• Investigate how the use and abolishment of DDT have affected the population of birds in your country.

Tip : Each example research title requires that you consult authoritative scientific reports to improve the quality of your paper. Furthermore, specificity and preciseness are required in each example of research title and problem, which only an authority source can provide.

• Discuss the importance of a major historical event and why it was so important in the day. These events can include the assassination of John F. Kennedy or some revolutionary document like the Magna Carta.
• Consider voyagers such as the Vikings, Chinese, as well as native populations and investigate whether Columbus discovered America first.
• Choose a named historical group, family, or individual through their biographies, examining them for reader responses.
• Research people of different cultural orientations and their responses to the acts of others who live around them.
• Investigate natural disasters in a named country and how the government has responded to them. For example, explore how the response of the New Orleans government to natural disasters has changed since Hurricane Katrina.

Tip : Focus this research title sample on one particular country or natural disaster or compare the responses of two countries with each other.

• Explore the educational policy, “no child left behind,” investigating its benefits and drawbacks.
• Investigate the concept of plagiarism in the twenty-first century, its consequences, and its prevalence in modern universities. Take a step further to investigate how and why many students don’t understand the gravity of their errors.
• Do in-depth research on bullying in schools, explaining the seriousness of the problem in your area in particular. Also, recommend actions schools, teachers, and parents can take to improve the situation if anything.
• Explore the place of religion in public schools; if it has a place, explain why, and if it does not, explain why not.
• Does a student’s financial background have any effect on his or her academic performance? In this sample research title, you can compare students from different financial backgrounds, from wealthy to average, and their scores on standardized tests.
• Is spanking one’s child considered child abuse; if so, why? In this research problem example for students, consider whether or not parents should be able to spank their children.
• Investigate the relationship between family health and nutrition, focusing on particular nutrition. This example of the title of the research study, for instance, can focus on the relationship between breastfeeding and baby health.
• Elucidate on, if any, the benefits of having a home-cooked meal and sitting down as a family to eat together.
• Explore the effect of fast-food restaurants on family health and nutrition, and whether or not they should be regulated.
• Research local food producers and farms in your community, pinpointing how much of your diet is acquired from them.

Tip : These are great research titles from which you can coin research topics for STEM students .

• Compare and contrast the two major operating systems: Mac and Windows, and discuss which one is better.

Tip : This title of the research study example can lead to strong uninformed opinions on the matter. However, it is important to investigate and discuss facts about the two operating systems, basing your conclusions on these.

• Explain the effect of spell checkers, autocorrect functions, and grammar checkers on the writing skills of computer users. Have these tools improved users’ writing skills or weakened them?

Tip : For this example of title research, it is better to consider more than one of these tools to write a comprehensive paper.

• Discuss the role(s) artificial intelligence is playing now or will likely play in the future as regards human evolution.
• Identify and investigate the next groundbreaking development in computer science (like the metaverse), explaining why you believe it will be important.
• Discuss a particular trendsetting technological tool, like blockchain technology, and how it has benefited different sectors.

Tip : For this research title example, you may want to focus on the effect of one tool on one particular sector. This way, you can investigate this example of research and thesis statement about social media more thoroughly and give as many details as possible.

• Consider your personal experiences as well as close friends’ and families experiences. Then, determine how marketing has invaded your lives and whether these impersonal communications are more positive than negative or vice versa.
• Investigate the regulations (or lack thereof) that apply to marketing items to children in your region. Do you think these regulations are unfounded, right, or inadequate?
• Investigate the merits and demerits of outsourcing customer services; you can compare the views of businesses with those of their customers.
• How has the communication we do through blog sites, messaging, social media, email, and other online platforms improved interpersonal communications if it has?
• Can understanding culture change the way you do business? Discuss how.

Tip : Ensure you share your reasoning on this title of the research study example and provide evidence-backed information to support your points.

• Learn everything you can about eating disorders like bulimia and anorexia, as well as their causes, and symptoms. Then, investigate and discuss the impact of its significance and recommend actions that might improve the situation.
• Research a major development in women’s history, like the admission of women to higher institutions and the legalization of abortion. Discuss the short-term and (or) long-term implications of the named event or development.
• Discuss gender inequality in the workplace – for instance, the fact that women tend to earn less than men for doing the same job. Provide specific real-life examples as you explain the reasons for this and recommend solutions to the problem.
• How have beauty contests helped women: have they empowered them in society or objectified them?

Tip : You may shift the focus of this topic research example to female strippers or women who act in pornographic movies.

• Investigate exceptional businesswomen in the 21st century; you can focus on one or compare two or more.

Tip : When writing on the title of a research example related to women, avoid using persuasion tactics; instead, be tactful and professional in presenting your points.

• Discuss the unique nature and implications of Donald Trump’s presidency on the United States and the world.
• Investigate the conditions and forces related to the advent and rise of Nazi Germany. Shift the focus of this title research example on major wars like WWI or the American Civil War.
• Is the enormous amount of money spent during election campaigns a legitimate expense?
• Investigate a named major political scandal that recently occurred in your region or country. Discuss how it started, how its news spread, and its impacts on individuals in that area.
• Discuss the impacts British rule had on India.
• Investigate the rate of incarceration in your region and compare it with that of other countries or other regions.
• Is incarcerating criminals an effective solution in promoting the rehabilitation of criminals and controlling crime rates?
• Consider various perspectives on the issue of gun control and coin several argumentative essay topics on the matter.
• Why do drivers continue to text while driving despite legal implications and dire consequences?
• Discuss the legality of people taking their own lives due to suffering from a debilitating terminal disease.

Each example of the research title provided in this article will make for a rich, information-dense research paper. However, you have a part to play in researching thoroughly on the example of the research study. To simplify the entire process for you, hiring our writing services is key as you wouldn’t have to worry about choosing topics. Our team of skilled writers knows the right subject that suits your research and how to readily get materials on them.

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200+ Research Title Ideas To Explore In 2024

Choosing a compelling research title is a critical step in the research process, as it serves as the gateway to capturing the attention of readers and potential collaborators. A well-crafted research title not only encapsulates the essence of your study but also entices readers to delve deeper into your work. 

In this blog post, we will explore the significance of research title ideas, the characteristics of an effective title, strategies for generating compelling titles, examples of successful titles, common pitfalls to avoid, the importance of iterative refinement, and ethical considerations in title creation.

Characteristics of a Good Research Title

Table of Contents

Clarity and Precision

A good research title should communicate the core idea of your study clearly and precisely. Avoid vague or overly complex language that might confuse readers.

Relevance to the Research Topic

Ensure that your title accurately reflects the content and focus of your research. It should provide a clear indication of what readers can expect from your study.

Conciseness and Avoidance of Ambiguity

Keep your title concise and to the point. Avoid unnecessary words or phrases that may add ambiguity. Aim for clarity and directness to make your title more impactful.

Use of Keywords

Incorporating relevant keywords in your title can enhance its visibility and accessibility. Consider the terms that researchers in your field are likely to search for and integrate them into your title.

Reflecting the Research Methodology or Approach

If your research employs a specific methodology or approach, consider incorporating that information into your title. This helps set expectations for readers and indicates the uniqueness of your study.

What are the Strategies for Generating Research Title Ideas?

• Brainstorming
• Individual Brainstorming: Set aside time to generate title ideas on your own. Consider different angles, perspectives, and aspects of your research.
• Group Brainstorming: Collaborate with peers or mentors to gather diverse perspectives and insights. Group brainstorming can lead to innovative and multidimensional title ideas.
• Keyword Analysis
• Identifying Key Terms and Concepts: Break down your research into key terms and concepts. These will form the foundation of your title.
• Exploring Synonyms and Related Terms: Expand your search by exploring synonyms and related terms. This can help you discover alternative ways to express your research focus.
• Literature Review
• Examining Existing Titles in the Field: Review titles of relevant studies in your field to identify common patterns and effective strategies.
• Analyzing Successful Titles for Inspiration: Analyze successful research titles to understand what makes them stand out. Look for elements that resonate with your own research.
• Consultation with Peers and Mentors
• Seek feedback from peers and mentors during the title creation process. External perspectives can offer valuable insights and help refine your ideas.
• Use of Online Tools and Title Generators
• Explore online tools and title generators designed to aid in the generation of creative and relevant research titles. While these tools can be helpful, exercise discretion and ensure the generated titles align with the essence of your research.

200+ Research Title Ideas: Category-Wise

Technology and computer science.

• “Cybersecurity Measures in the Age of Quantum Computing”
• “Machine Learning Applications for Predictive Maintenance”
• “The Impact of Augmented Reality on Learning Outcomes”
• “Blockchain Technology: Enhancing Supply Chain Transparency”
• “Human-Computer Interaction in Virtual Reality Environments”

Environmental Science and Sustainability

• “Evaluating the Efficacy of Green Infrastructure in Urban Areas”
• “Climate Change Resilience Strategies for Coastal Communities”
• “Biodiversity Conservation in Tropical Rainforests”
• “Renewable Energy Adoption in Developing Economies”
• “Assessing the Environmental Impact of Plastic Alternatives”

Health and Medicine

• “Precision Medicine Approaches in Cancer Treatment”
• “Mental Health Interventions for Youth in Urban Settings”
• “Telemedicine: Bridging Gaps in Rural Healthcare Access”
• “The Role of Gut Microbiota in Metabolic Disorders”
• “Ethical Considerations in Genetic Editing Technologies”

Social Sciences and Psychology

• “Social Media Influence on Body Image Perception”
• “Impact of Cultural Diversity on Team Performance”
• “Psychological Resilience in the Face of Global Crises”
• “Parental Involvement and Academic Achievement in Adolescents”
• “Exploring the Dynamics of Online Communities and Identity”

Business and Economics

• “Sustainable Business Practices and Consumer Behavior”
• “The Role of Big Data in Financial Decision-Making”
• “Entrepreneurship and Innovation in Emerging Markets”
• “Corporate Social Responsibility and Brand Loyalty”
• “Economic Implications of Remote Work Adoption”

Education and Pedagogy

• “Inclusive Education Models for Diverse Learning Needs”
• “Gamification in STEM Education: A Comparative Analysis”
• “Online Learning Effectiveness in Higher Education”
• “Teacher Training for Integrating Technology in Classrooms”
• “Assessment Strategies for Measuring Critical Thinking Skills”

Psychology and Behavior

• “The Influence of Social Media on Adolescent Well-being”
• “Cognitive Biases in Decision-Making: A Cross-Cultural Study”
• “The Role of Empathy in Conflict Resolution”
• “Positive Psychology Interventions for Workplace Satisfaction”
• “Exploring the Relationship Between Sleep Patterns and Mental Health”

Biology and Genetics

• “Genetic Markers for Predisposition to Neurodegenerative Diseases”
• “CRISPR-Cas9 Technology: Ethical Implications and Future Prospects”
• “Evolutionary Adaptations in Response to Environmental Changes”
• “Understanding the Microbiome’s Impact on Immune System Function”
• “Epigenetic Modifications and Their Role in Disease Development”

Urban Planning and Architecture

• “Smart Cities: Balancing Technological Innovation and Privacy”
• “Revitalizing Urban Spaces: Community Engagement in Design”
• “Sustainable Architecture: Integrating Nature into Urban Designs”
• “Transit-Oriented Development and Its Impact on City Dynamics”
• “Assessing the Cultural Significance of Urban Landscapes”

Linguistics and Communication

• “The Influence of Language on Cross-Cultural Communication”
• “Language Development in Multilingual Environments”
• “The Impact of Nonverbal Communication on Interpersonal Relationships”
• “Digital Communication and the Evolution of Language”
• “Language Processing in Bilingual Individuals: A Neuroscientific Approach”

Political Science and International Relations

• “The Role of Social Media in Political Mobilization”
• “Global Governance in the Era of Transnational Challenges”
• “Human Rights and the Ethics of Intervention in International Affairs”
• “Political Polarization: Causes and Consequences”
• “Climate Change Diplomacy: Assessing International Agreements”

Physics and Astronomy

• “Dark Matter: Unraveling the Mysteries of the Universe”
• “Quantum Entanglement and Its Potential Applications”
• “The Search for Exoplanets in Habitable Zones”
• “Astrophysical Phenomena: Exploring Black Holes and Neutron Stars”
• “Advancements in Quantum Computing Algorithms”

Education Technology (EdTech)

• “Adaptive Learning Platforms: Personalizing Education for Every Student”
•  “The Impact of Virtual Reality Simulations on STEM Education”
• “E-Learning Accessibility for Students with Disabilities”
• “Gamified Learning: Enhancing Student Engagement and Retention”
• “Digital Literacy Education: Navigating the Information Age”

Sociology and Anthropology

• “Cultural Shifts in Modern Society: An Anthropological Exploration”
• “Social Movements in the Digital Age: Activism and Connectivity”
• “Gender Roles and Equality: A Cross-Cultural Perspective”
•  “Urbanization and Its Effects on Traditional Societal Structures”
• “Cultural Appropriation: Understanding Boundaries and Respect”

Materials Science and Engineering

• “Nanostructured Materials: Innovations in Manufacturing and Applications”
•  “Biodegradable Polymers: Towards Sustainable Packaging Solutions”
• “Materials for Energy Storage: Advancements and Challenges”
• “Smart Materials in Healthcare: From Diagnosis to Treatment”
• “Robust Coatings for Extreme Environments: Applications in Aerospace”

History and Archaeology

• “Digital Reconstruction of Historical Sites: Preserving the Past”
• “Trade Routes in Ancient Civilizations: A Comparative Study”
• “Archaeogenetics: Unraveling Human Migrations Through DNA Analysis”
• “Historical Linguistics: Tracing Language Evolution Over Millennia”
• “The Archaeology of Conflict: Studying War through Artifacts”

Marketing and Consumer Behavior

• “Influencer Marketing: Impact on Consumer Trust and Purchasing Decisions”
• “The Role of Brand Storytelling in Consumer Engagement”
• “E-commerce Personalization Strategies: Balancing Customization and Privacy”
• “Cross-Cultural Marketing: Adapting Campaigns for Global Audiences”
• “Consumer Perceptions of Sustainable Products: A Market Analysis”

Neuroscience and Cognitive Science

• “Neuroplasticity and Cognitive Rehabilitation: Implications for Therapy”
• “The Neuroscience of Decision-Making: Insights from Brain Imaging”
• “Cognitive Aging: Understanding Memory Decline and Cognitive Resilience”
• “The Role of Neurotransmitters in Emotional Regulation”
• “Neuroethical Considerations in Brain-Computer Interface Technologies”

Public Health and Epidemiology

• “Epidemiological Trends in Infectious Diseases: Lessons from Global Outbreaks”
• “Public Health Interventions for Reducing Non-Communicable Diseases”
• “Health Disparities Among Marginalized Communities: Addressing the Gaps”
• “The Impact of Climate Change on Vector-Borne Diseases”
• “Community-Based Approaches to Promoting Health Equity”

Robotics and Automation

• “Human-Robot Collaboration in Manufacturing: Enhancing Productivity and Safety”
• “Autonomous Vehicles: Navigating the Path to Mainstream Adoption”
• “Soft Robotics: Engineering Flexibility for Real-World Applications”
• “Ethical Considerations in the Development of AI-powered Robotics”
• “Bio-Inspired Robotics: Learning from Nature to Enhance Machine Intelligence”

Literature and Literary Criticism

• “Postcolonial Narratives: Deconstructing Power Structures in Literature”
• “Digital Storytelling Platforms: Changing the Landscape of Narrative Arts”
• “Literature and Cultural Identity: Exploring Representations in Global Contexts”
• “Eco-Critical Perspectives in Contemporary Literature”
• “Feminist Literary Criticism: Reinterpreting Classic Texts Through a New Lens”

Chemistry and Chemical Engineering

• “Green Chemistry: Sustainable Approaches to Chemical Synthesis”
• “Nanomaterials for Drug Delivery: Innovations in Biomedical Applications”
• “Chemical Process Optimization: Towards Energy-Efficient Production”
• “The Chemistry of Taste: Molecular Insights into Food Flavors”
•  “Catalytic Converters: Advancements in Pollution Control Technologies”

Cultural Studies and Media

• “Media Representations of Social Movements: Framing and Impact”
• “Pop Culture and Identity: Exploring Trends in a Globalized World”
• “The Influence of Social Media on Political Discourse”
• “Reality Television and Perceptions of Reality: A Cultural Analysis”
• “Media Literacy Education: Navigating the Digital Information Age”

Astronomy and Astrophysics

• “Gravitational Waves: Probing the Cosmos for New Discoveries”
• “The Life Cycle of Stars: From Birth to Supernova”
•  “Astrobiology: Searching for Extraterrestrial Life in the Universe”
• “Dark Energy and the Accelerating Expansion of the Universe”
• “Cosmic Microwave Background: Insights into the Early Universe”

Social Work and Community Development

• “Community-Based Mental Health Interventions: A Social Work Perspective”
• “Youth Empowerment Programs: Fostering Resilience in Vulnerable Communities”
• “Social Justice Advocacy in Contemporary Social Work Practice”
• “Intersectionality in Social Work: Addressing the Complex Needs of Individuals”
• “The Role of Technology in Enhancing Social Services Delivery”

Artificial Intelligence and Ethics

• “Ethical Considerations in AI Decision-Making: Balancing Autonomy and Accountability”
• “Bias and Fairness in Machine Learning Algorithms: A Critical Examination”
•  “Explainable AI: Bridging the Gap Between Complexity and Transparency”
• “The Social Implications of AI-Generated Content: Challenges and Opportunities”
• “AI and Personal Privacy: Navigating the Ethical Dimensions of Data Usage”

Linguistics and Computational Linguistics

• “Natural Language Processing: Advancements in Understanding Human Communication”
• “Multilingualism in the Digital Age: Challenges and Opportunities”
•  “Cognitive Linguistics: Exploring the Relationship Between Language and Thought”
• “Speech Recognition Technologies: Applications in Everyday Life”
• “Syntax and Semantics: Unraveling the Structure of Language”

Geology and Earth Sciences

• “Geological Hazards Assessment in Urban Planning: A Case Study”
• “Paleoclimatology: Reconstructing Past Climate Patterns for Future Predictions”
• “Geomorphological Processes in Coastal Landscapes: Implications for Conservation”
• “Volcanic Activity Monitoring: Early Warning Systems and Mitigation Strategies”
• “The Impact of Human Activities on Soil Erosion: An Ecological Perspective”

Political Economy and Global Governance

• “Global Trade Agreements: Assessing Economic Impacts and Equity”
• “Political Economy of Energy Transition: Policies and Socioeconomic Effects”
• “The Role of International Organizations in Global Governance”
• “Financial Inclusion and Economic Development: A Comparative Analysis”
•  “The Political Economy of Pandemics: Governance and Crisis Response”

Food Science and Nutrition

• “Nutrigenomics: Personalized Nutrition for Optimal Health”
• “Functional Foods: Exploring Health Benefits Beyond Basic Nutrition”
• “Sustainable Food Production: Innovations in Agriculture and Aquaculture”
•  “Dietary Patterns and Mental Health: A Comprehensive Review”
• “Food Allergies and Sensitivities: Mechanisms and Management Strategies”

Sociology and Technology

• “Digital Inequalities: Examining Access and Usage Patterns Across Demographics”
• “The Impact of Social Media on Social Capital and Community Building”
• “Technological Surveillance and Privacy Concerns: A Sociological Analysis”
• “Virtual Communities: An Exploration of Identity Formation in Online Spaces”
• “The Social Dynamics of Online Activism: Mobilization and Participation”

Materials Science and Nanotechnology

• “Nanomaterials for Biomedical Imaging: Enhancing Diagnostic Precision”
• “Self-Healing Materials: Advances in Sustainable and Resilient Infrastructure”
• “Smart Textiles: Integrating Nanotechnology for Enhanced Functionality”
• “Multifunctional Nanoparticles in Drug Delivery: Targeted Therapies and Beyond”
• “Nanocomposites for Energy Storage: Engineering Efficient Capacitors”

Communication and Media Studies

• “Media Convergence: The Evolution of Content Delivery in the Digital Age”
• “The Impact of Social Media Influencers on Consumer Behavior”
• “Crisis Communication in a Hyperconnected World: Lessons from Global Events”
• “Media Framing of Environmental Issues: A Comparative Analysis”
• “Digital Detox: Understanding Media Consumption Patterns and Well-being”

Developmental Psychology

• “Early Childhood Attachment and Its Long-Term Impact on Adult Relationships”
• “Cognitive Development in Adolescence: Challenges and Opportunities”
• “Parenting Styles and Academic Achievement: A Cross-Cultural Perspective”
• “Identity Formation in Emerging Adulthood: The Role of Social Influences”
• “Interventions for Promoting Resilience in At-Risk Youth Populations”

Aerospace Engineering

• “Advancements in Aerodynamics: Redefining Flight Efficiency”
• “Space Debris Management: Mitigating Risks in Earth’s Orbit”
• “Aerodynamic Design Optimization for Supersonic Flight”
• “Hypersonic Propulsion Technologies: Pushing the Boundaries of Speed”
• “Materials for Space Exploration: Engineering Solutions for Harsh Environments”

Political Psychology

• “Political Polarization and Public Opinion: Exploring Cognitive Biases”
• “Leadership Styles and Public Perception: A Psychological Analysis”
• “Nationalism and Identity: Psychological Factors Shaping Political Beliefs”
• “The Influence of Emotional Appeals in Political Communication”
• “Crisis Leadership: The Psychological Dynamics of Decision-Making in Times of Uncertainty”

Marine Biology and Conservation

• “Coral Reef Restoration: Strategies for Biodiversity Conservation”
• “Ocean Plastic Pollution: Assessing Impacts on Marine Ecosystems”
• “Marine Mammal Communication: Insights from Bioacoustics”
• “Sustainable Fisheries Management: Balancing Ecological and Economic Concerns”
• “The Role of Mangrove Ecosystems in Coastal Resilience”

Artificial Intelligence and Creativity

• “Generative AI in Creative Industries: Challenges and Innovations”
• “AI-Enhanced Creativity Tools: Empowering Artists and Designers”
• “Machine Learning for Music Composition: Bridging Art and Technology”
• “Creative AI in Film and Entertainment: Transforming Storytelling”
• “Ethical Considerations in AI-Generated Art and Content”

Cultural Anthropology

• “Cultural Relativism in Anthropological Research: Opportunities and Challenges”
• “Rituals and Symbolism: Unraveling Cultural Practices Across Societies”
• “Migration and Cultural Identity: An Ethnographic Exploration”
• “Material Culture Studies: Understanding Societies through Objects”
• “Indigenous Knowledge Systems: Preserving and Promoting Cultural Heritage”

Quantum Computing and Information Science

• “Quantum Information Processing: Algorithms and Applications”
• “Quantum Cryptography: Securing Communication in the Quantum Era”
•  “Quantum Machine Learning: Enhancing AI through Quantum Computing”
• “Quantum Computing in Finance: Opportunities and Challenges”
• “Quantum Internet: Building the Next Generation of Information Networks”

Public Policy and Urban Planning

• “Smart Cities and Inclusive Urban Development: A Policy Perspective”
• “Public-Private Partnerships in Infrastructure Development: Lessons Learned”
• “The Impact of Transportation Policies on Urban Mobility Patterns”
• “Housing Affordability: Policy Approaches to Addressing Urban Challenges”
• “Data-Driven Decision-Making in Urban Governance: Opportunities and Risks”

Gerontology and Aging Studies

• “Healthy Aging Interventions: Promoting Quality of Life in Older Adults”
• “Social Isolation and Mental Health in Aging Populations: Interventions and Support”
• “Technology Adoption Among Older Adults: Bridging the Digital Divide”
• “End-of-Life Decision-Making: Ethical Considerations and Legal Frameworks”
• “Cognitive Resilience in Aging: Strategies for Maintaining Mental Sharpness”

Examples of Effective Research Titles

Illustrative Examples from Various Disciplines

Here are examples of effective research titles from different disciplines:

• “Unlocking the Mysteries of Neural Plasticity: A Multidisciplinary Approach”
• “Sustainable Urban Development: Integrating Environmental and Social Perspectives”
• “Quantum Computing: Navigating the Path to Practical Applications”

Analysis of What Makes Each Title Effective

• Clear indication of the research focus.
• Inclusion of key terms relevant to the field.
• Incorporation of a multidisciplinary or integrated approach where applicable.

Common Pitfalls to Avoid in Research Title Creation

A. Vagueness and Ambiguity

Vague or ambiguous titles can deter readers from engaging with your research. Ensure your title is straightforward and leaves no room for misinterpretation.

B. Overuse of Jargon

While technical terms are essential, excessive jargon can alienate readers who may not be familiar with the specific terminology. Strike a balance between precision and accessibility.

C. Lack of Alignment with Research Objectives

Your title should align seamlessly with the objectives and findings of your research. Avoid creating titles that misrepresent the core contributions of your study.

D. Lengthy and Complicated Titles

Lengthy titles can be overwhelming and may not effectively convey the essence of your research. Aim for brevity while maintaining clarity and informativeness.

E. Lack of Creativity and Engagement

A bland title may not capture the interest of potential readers. Inject creativity where appropriate and strive to create a title that sparks curiosity.

Ethical Considerations in Research Title Creation

• Avoiding Sensationalism and Misleading Titles

Ensure that your title accurately represents the content of your research. Avoid sensationalism or misleading language that may compromise the integrity of your work.

• Ensuring Accuracy and Integrity in Representing Research Content

Your title should uphold the principles of accuracy and integrity. Any claims or implications in the title should be supported by the actual findings of your research.

Crafting a captivating research title is a nuanced process that requires careful consideration of various factors. From clarity and relevance to creativity and ethical considerations, each element plays a crucial role in the success of your title. 

By following the outlined strategies and avoiding common pitfalls for research title ideas, researchers can enhance the visibility and impact of their work, contributing to the broader scholarly conversation. Remember, your research title is the first impression readers have of your work, so make it count.

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13.1 Formatting a Research Paper

Learning objectives.

• Identify the major components of a research paper written using American Psychological Association (APA) style.
• Apply general APA style and formatting conventions in a research paper.

In this chapter, you will learn how to use APA style , the documentation and formatting style followed by the American Psychological Association, as well as MLA style , from the Modern Language Association. There are a few major formatting styles used in academic texts, including AMA, Chicago, and Turabian:

• AMA (American Medical Association) for medicine, health, and biological sciences
• APA (American Psychological Association) for education, psychology, and the social sciences
• Chicago—a common style used in everyday publications like magazines, newspapers, and books
• MLA (Modern Language Association) for English, literature, arts, and humanities
• Turabian—another common style designed for its universal application across all subjects and disciplines

While all the formatting and citation styles have their own use and applications, in this chapter we focus our attention on the two styles you are most likely to use in your academic studies: APA and MLA.

If you find that the rules of proper source documentation are difficult to keep straight, you are not alone. Writing a good research paper is, in and of itself, a major intellectual challenge. Having to follow detailed citation and formatting guidelines as well may seem like just one more task to add to an already-too-long list of requirements.

Following these guidelines, however, serves several important purposes. First, it signals to your readers that your paper should be taken seriously as a student’s contribution to a given academic or professional field; it is the literary equivalent of wearing a tailored suit to a job interview. Second, it shows that you respect other people’s work enough to give them proper credit for it. Finally, it helps your reader find additional materials if he or she wishes to learn more about your topic.

Furthermore, producing a letter-perfect APA-style paper need not be burdensome. Yes, it requires careful attention to detail. However, you can simplify the process if you keep these broad guidelines in mind:

• Work ahead whenever you can. Chapter 11 “Writing from Research: What Will I Learn?” includes tips for keeping track of your sources early in the research process, which will save time later on.
• Get it right the first time. Apply APA guidelines as you write, so you will not have much to correct during the editing stage. Again, putting in a little extra time early on can save time later.
• Use the resources available to you. In addition to the guidelines provided in this chapter, you may wish to consult the APA website at http://www.apa.org or the Purdue University Online Writing lab at http://owl.english.purdue.edu , which regularly updates its online style guidelines.

General Formatting Guidelines

This chapter provides detailed guidelines for using the citation and formatting conventions developed by the American Psychological Association, or APA. Writers in disciplines as diverse as astrophysics, biology, psychology, and education follow APA style. The major components of a paper written in APA style are listed in the following box.

These are the major components of an APA-style paper:

Body, which includes the following:

• Headings and, if necessary, subheadings to organize the content
• In-text citations of research sources
• References page

All these components must be saved in one document, not as separate documents.

The title page of your paper includes the following information:

• Title of the paper
• Author’s name
• Name of the institution with which the author is affiliated
• Header at the top of the page with the paper title (in capital letters) and the page number (If the title is lengthy, you may use a shortened form of it in the header.)

List the first three elements in the order given in the previous list, centered about one third of the way down from the top of the page. Use the headers and footers tool of your word-processing program to add the header, with the title text at the left and the page number in the upper-right corner. Your title page should look like the following example.

The next page of your paper provides an abstract , or brief summary of your findings. An abstract does not need to be provided in every paper, but an abstract should be used in papers that include a hypothesis. A good abstract is concise—about one hundred fifty to two hundred fifty words—and is written in an objective, impersonal style. Your writing voice will not be as apparent here as in the body of your paper. When writing the abstract, take a just-the-facts approach, and summarize your research question and your findings in a few sentences.

In Chapter 12 “Writing a Research Paper” , you read a paper written by a student named Jorge, who researched the effectiveness of low-carbohydrate diets. Read Jorge’s abstract. Note how it sums up the major ideas in his paper without going into excessive detail.

Write an abstract summarizing your paper. Briefly introduce the topic, state your findings, and sum up what conclusions you can draw from your research. Use the word count feature of your word-processing program to make sure your abstract does not exceed one hundred fifty words.

Depending on your field of study, you may sometimes write research papers that present extensive primary research, such as your own experiment or survey. In your abstract, summarize your research question and your findings, and briefly indicate how your study relates to prior research in the field.

Margins, Pagination, and Headings

APA style requirements also address specific formatting concerns, such as margins, pagination, and heading styles, within the body of the paper. Review the following APA guidelines.

Use these general guidelines to format the paper:

• Set the top, bottom, and side margins of your paper at 1 inch.
• Use double-spaced text throughout your paper.
• Use a standard font, such as Times New Roman or Arial, in a legible size (10- to 12-point).
• Use continuous pagination throughout the paper, including the title page and the references section. Page numbers appear flush right within your header.
• Section headings and subsection headings within the body of your paper use different types of formatting depending on the level of information you are presenting. Additional details from Jorge’s paper are provided.

Begin formatting the final draft of your paper according to APA guidelines. You may work with an existing document or set up a new document if you choose. Include the following:

• Your title page
• The abstract you created in Note 13.8 “Exercise 1”
• Correct headers and page numbers for your title page and abstract

APA style uses section headings to organize information, making it easy for the reader to follow the writer’s train of thought and to know immediately what major topics are covered. Depending on the length and complexity of the paper, its major sections may also be divided into subsections, sub-subsections, and so on. These smaller sections, in turn, use different heading styles to indicate different levels of information. In essence, you are using headings to create a hierarchy of information.

The following heading styles used in APA formatting are listed in order of greatest to least importance:

• Section headings use centered, boldface type. Headings use title case, with important words in the heading capitalized.
• Subsection headings use left-aligned, boldface type. Headings use title case.
• The third level uses left-aligned, indented, boldface type. Headings use a capital letter only for the first word, and they end in a period.
• The fourth level follows the same style used for the previous level, but the headings are boldfaced and italicized.
• The fifth level follows the same style used for the previous level, but the headings are italicized and not boldfaced.

Visually, the hierarchy of information is organized as indicated in Table 13.1 “Section Headings” .

Table 13.1 Section Headings

A college research paper may not use all the heading levels shown in Table 13.1 “Section Headings” , but you are likely to encounter them in academic journal articles that use APA style. For a brief paper, you may find that level 1 headings suffice. Longer or more complex papers may need level 2 headings or other lower-level headings to organize information clearly. Use your outline to craft your major section headings and determine whether any subtopics are substantial enough to require additional levels of headings.

Working with the document you developed in Note 13.11 “Exercise 2” , begin setting up the heading structure of the final draft of your research paper according to APA guidelines. Include your title and at least two to three major section headings, and follow the formatting guidelines provided above. If your major sections should be broken into subsections, add those headings as well. Use your outline to help you.

Because Jorge used only level 1 headings, his Exercise 3 would look like the following:

Citation Guidelines

In-text citations.

Throughout the body of your paper, include a citation whenever you quote or paraphrase material from your research sources. As you learned in Chapter 11 “Writing from Research: What Will I Learn?” , the purpose of citations is twofold: to give credit to others for their ideas and to allow your reader to follow up and learn more about the topic if desired. Your in-text citations provide basic information about your source; each source you cite will have a longer entry in the references section that provides more detailed information.

In-text citations must provide the name of the author or authors and the year the source was published. (When a given source does not list an individual author, you may provide the source title or the name of the organization that published the material instead.) When directly quoting a source, it is also required that you include the page number where the quote appears in your citation.

This information may be included within the sentence or in a parenthetical reference at the end of the sentence, as in these examples.

Epstein (2010) points out that “junk food cannot be considered addictive in the same way that we think of psychoactive drugs as addictive” (p. 137).

Here, the writer names the source author when introducing the quote and provides the publication date in parentheses after the author’s name. The page number appears in parentheses after the closing quotation marks and before the period that ends the sentence.

Addiction researchers caution that “junk food cannot be considered addictive in the same way that we think of psychoactive drugs as addictive” (Epstein, 2010, p. 137).

Here, the writer provides a parenthetical citation at the end of the sentence that includes the author’s name, the year of publication, and the page number separated by commas. Again, the parenthetical citation is placed after the closing quotation marks and before the period at the end of the sentence.

As noted in the book Junk Food, Junk Science (Epstein, 2010, p. 137), “junk food cannot be considered addictive in the same way that we think of psychoactive drugs as addictive.”

Here, the writer chose to mention the source title in the sentence (an optional piece of information to include) and followed the title with a parenthetical citation. Note that the parenthetical citation is placed before the comma that signals the end of the introductory phrase.

David Epstein’s book Junk Food, Junk Science (2010) pointed out that “junk food cannot be considered addictive in the same way that we think of psychoactive drugs as addictive” (p. 137).

Another variation is to introduce the author and the source title in your sentence and include the publication date and page number in parentheses within the sentence or at the end of the sentence. As long as you have included the essential information, you can choose the option that works best for that particular sentence and source.

Citing a book with a single author is usually a straightforward task. Of course, your research may require that you cite many other types of sources, such as books or articles with more than one author or sources with no individual author listed. You may also need to cite sources available in both print and online and nonprint sources, such as websites and personal interviews. Chapter 13 “APA and MLA Documentation and Formatting” , Section 13.2 “Citing and Referencing Techniques” and Section 13.3 “Creating a References Section” provide extensive guidelines for citing a variety of source types.

Writing at Work

APA is just one of several different styles with its own guidelines for documentation, formatting, and language usage. Depending on your field of interest, you may be exposed to additional styles, such as the following:

• MLA style. Determined by the Modern Languages Association and used for papers in literature, languages, and other disciplines in the humanities.
• Chicago style. Outlined in the Chicago Manual of Style and sometimes used for papers in the humanities and the sciences; many professional organizations use this style for publications as well.
• Associated Press (AP) style. Used by professional journalists.

References List

The brief citations included in the body of your paper correspond to the more detailed citations provided at the end of the paper in the references section. In-text citations provide basic information—the author’s name, the publication date, and the page number if necessary—while the references section provides more extensive bibliographical information. Again, this information allows your reader to follow up on the sources you cited and do additional reading about the topic if desired.

The specific format of entries in the list of references varies slightly for different source types, but the entries generally include the following information:

• The name(s) of the author(s) or institution that wrote the source
• The year of publication and, where applicable, the exact date of publication
• The full title of the source
• For books, the city of publication
• For articles or essays, the name of the periodical or book in which the article or essay appears
• For magazine and journal articles, the volume number, issue number, and pages where the article appears
• For sources on the web, the URL where the source is located

The references page is double spaced and lists entries in alphabetical order by the author’s last name. If an entry continues for more than one line, the second line and each subsequent line are indented five spaces. Review the following example. ( Chapter 13 “APA and MLA Documentation and Formatting” , Section 13.3 “Creating a References Section” provides extensive guidelines for formatting reference entries for different types of sources.)

In APA style, book and article titles are formatted in sentence case, not title case. Sentence case means that only the first word is capitalized, along with any proper nouns.

Key Takeaways

• Following proper citation and formatting guidelines helps writers ensure that their work will be taken seriously, give proper credit to other authors for their work, and provide valuable information to readers.
• Working ahead and taking care to cite sources correctly the first time are ways writers can save time during the editing stage of writing a research paper.
• APA papers usually include an abstract that concisely summarizes the paper.
• APA papers use a specific headings structure to provide a clear hierarchy of information.
• In APA papers, in-text citations usually include the name(s) of the author(s) and the year of publication.
• In-text citations correspond to entries in the references section, which provide detailed bibliographical information about a source.

Writing for Success Copyright © 2015 by University of Minnesota is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License , except where otherwise noted.

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Home » Background of The Study – Examples and Writing Guide

Background of The Study – Examples and Writing Guide

Table of Contents

Background of The Study

Definition:

Background of the study refers to the context, circumstances, and history that led to the research problem or topic being studied. It provides the reader with a comprehensive understanding of the subject matter and the significance of the study.

The background of the study usually includes a discussion of the relevant literature, the gap in knowledge or understanding, and the research questions or hypotheses to be addressed. It also highlights the importance of the research topic and its potential contributions to the field. A well-written background of the study sets the stage for the research and helps the reader to appreciate the need for the study and its potential significance.

How to Write Background of The Study

Here are some steps to help you write the background of the study:

Identify the Research Problem

Start by identifying the research problem you are trying to address. This problem should be significant and relevant to your field of study.

Provide Context

Once you have identified the research problem, provide some context. This could include the historical, social, or political context of the problem.

Review Literature

Conduct a thorough review of the existing literature on the topic. This will help you understand what has been studied and what gaps exist in the current research.

Identify Research Gap

Based on your literature review, identify the gap in knowledge or understanding that your research aims to address. This gap will be the focus of your research question or hypothesis.

State Objectives

Clearly state the objectives of your research . These should be specific, measurable, achievable, relevant, and time-bound (SMART).

Discuss Significance

Explain the significance of your research. This could include its potential impact on theory , practice, policy, or society.

Finally, summarize the key points of the background of the study. This will help the reader understand the research problem, its context, and its significance.

How to Write Background of The Study in Proposal

The background of the study is an essential part of any proposal as it sets the stage for the research project and provides the context and justification for why the research is needed. Here are the steps to write a compelling background of the study in your proposal:

• Identify the problem: Clearly state the research problem or gap in the current knowledge that you intend to address through your research.
• Provide context: Provide a brief overview of the research area and highlight its significance in the field.
• Review literature: Summarize the relevant literature related to the research problem and provide a critical evaluation of the current state of knowledge.
• Identify gaps : Identify the gaps or limitations in the existing literature and explain how your research will contribute to filling these gaps.
• Justify the study : Explain why your research is important and what practical or theoretical contributions it can make to the field.
• Highlight objectives: Clearly state the objectives of the study and how they relate to the research problem.
• Discuss methodology: Provide an overview of the methodology you will use to collect and analyze data, and explain why it is appropriate for the research problem.
• Conclude : Summarize the key points of the background of the study and explain how they support your research proposal.

How to Write Background of The Study In Thesis

The background of the study is a critical component of a thesis as it provides context for the research problem, rationale for conducting the study, and the significance of the research. Here are some steps to help you write a strong background of the study:

• Identify the research problem : Start by identifying the research problem that your thesis is addressing. What is the issue that you are trying to solve or explore? Be specific and concise in your problem statement.
• Review the literature: Conduct a thorough review of the relevant literature on the topic. This should include scholarly articles, books, and other sources that are directly related to your research question.
• I dentify gaps in the literature: After reviewing the literature, identify any gaps in the existing research. What questions remain unanswered? What areas have not been explored? This will help you to establish the need for your research.
• Establish the significance of the research: Clearly state the significance of your research. Why is it important to address this research problem? What are the potential implications of your research? How will it contribute to the field?
• Provide an overview of the research design: Provide an overview of the research design and methodology that you will be using in your study. This should include a brief explanation of the research approach, data collection methods, and data analysis techniques.
• State the research objectives and research questions: Clearly state the research objectives and research questions that your study aims to answer. These should be specific, measurable, achievable, relevant, and time-bound.
• Summarize the chapter: Summarize the chapter by highlighting the key points and linking them back to the research problem, significance of the study, and research questions.

How to Write Background of The Study in Research Paper

Here are the steps to write the background of the study in a research paper:

• Identify the research problem: Start by identifying the research problem that your study aims to address. This can be a particular issue, a gap in the literature, or a need for further investigation.
• Conduct a literature review: Conduct a thorough literature review to gather information on the topic, identify existing studies, and understand the current state of research. This will help you identify the gap in the literature that your study aims to fill.
• Explain the significance of the study: Explain why your study is important and why it is necessary. This can include the potential impact on the field, the importance to society, or the need to address a particular issue.
• Provide context: Provide context for the research problem by discussing the broader social, economic, or political context that the study is situated in. This can help the reader understand the relevance of the study and its potential implications.
• State the research questions and objectives: State the research questions and objectives that your study aims to address. This will help the reader understand the scope of the study and its purpose.
• Summarize the methodology : Briefly summarize the methodology you used to conduct the study, including the data collection and analysis methods. This can help the reader understand how the study was conducted and its reliability.

Examples of Background of The Study

Here are some examples of the background of the study:

Problem : The prevalence of obesity among children in the United States has reached alarming levels, with nearly one in five children classified as obese.

Significance : Obesity in childhood is associated with numerous negative health outcomes, including increased risk of type 2 diabetes, cardiovascular disease, and certain cancers.

Gap in knowledge : Despite efforts to address the obesity epidemic, rates continue to rise. There is a need for effective interventions that target the unique needs of children and their families.

Problem : The use of antibiotics in agriculture has contributed to the development of antibiotic-resistant bacteria, which poses a significant threat to human health.

Significance : Antibiotic-resistant infections are responsible for thousands of deaths each year and are a major public health concern.

Gap in knowledge: While there is a growing body of research on the use of antibiotics in agriculture, there is still much to be learned about the mechanisms of resistance and the most effective strategies for reducing antibiotic use.

Edxample 3:

Problem : Many low-income communities lack access to healthy food options, leading to high rates of food insecurity and diet-related diseases.

Significance : Poor nutrition is a major contributor to chronic diseases such as obesity, type 2 diabetes, and cardiovascular disease.

Gap in knowledge : While there have been efforts to address food insecurity, there is a need for more research on the barriers to accessing healthy food in low-income communities and effective strategies for increasing access.

Examples of Background of The Study In Research

Here are some real-life examples of how the background of the study can be written in different fields of study:

Example 1 : “There has been a significant increase in the incidence of diabetes in recent years. This has led to an increased demand for effective diabetes management strategies. The purpose of this study is to evaluate the effectiveness of a new diabetes management program in improving patient outcomes.”

Example 2 : “The use of social media has become increasingly prevalent in modern society. Despite its popularity, little is known about the effects of social media use on mental health. This study aims to investigate the relationship between social media use and mental health in young adults.”

Example 3: “Despite significant advancements in cancer treatment, the survival rate for patients with pancreatic cancer remains low. The purpose of this study is to identify potential biomarkers that can be used to improve early detection and treatment of pancreatic cancer.”

Examples of Background of The Study in Proposal

Here are some real-time examples of the background of the study in a proposal:

Example 1 : The prevalence of mental health issues among university students has been increasing over the past decade. This study aims to investigate the causes and impacts of mental health issues on academic performance and wellbeing.

Example 2 : Climate change is a global issue that has significant implications for agriculture in developing countries. This study aims to examine the adaptive capacity of smallholder farmers to climate change and identify effective strategies to enhance their resilience.

Example 3 : The use of social media in political campaigns has become increasingly common in recent years. This study aims to analyze the effectiveness of social media campaigns in mobilizing young voters and influencing their voting behavior.

Example 4 : Employee turnover is a major challenge for organizations, especially in the service sector. This study aims to identify the key factors that influence employee turnover in the hospitality industry and explore effective strategies for reducing turnover rates.

Examples of Background of The Study in Thesis

Here are some real-time examples of the background of the study in the thesis:

Example 1 : “Women’s participation in the workforce has increased significantly over the past few decades. However, women continue to be underrepresented in leadership positions, particularly in male-dominated industries such as technology. This study aims to examine the factors that contribute to the underrepresentation of women in leadership roles in the technology industry, with a focus on organizational culture and gender bias.”

Example 2 : “Mental health is a critical component of overall health and well-being. Despite increased awareness of the importance of mental health, there are still significant gaps in access to mental health services, particularly in low-income and rural communities. This study aims to evaluate the effectiveness of a community-based mental health intervention in improving mental health outcomes in underserved populations.”

Example 3: “The use of technology in education has become increasingly widespread, with many schools adopting online learning platforms and digital resources. However, there is limited research on the impact of technology on student learning outcomes and engagement. This study aims to explore the relationship between technology use and academic achievement among middle school students, as well as the factors that mediate this relationship.”

Examples of Background of The Study in Research Paper

Here are some examples of how the background of the study can be written in various fields:

Example 1: The prevalence of obesity has been on the rise globally, with the World Health Organization reporting that approximately 650 million adults were obese in 2016. Obesity is a major risk factor for several chronic diseases such as diabetes, cardiovascular diseases, and cancer. In recent years, several interventions have been proposed to address this issue, including lifestyle changes, pharmacotherapy, and bariatric surgery. However, there is a lack of consensus on the most effective intervention for obesity management. This study aims to investigate the efficacy of different interventions for obesity management and identify the most effective one.

Example 2: Antibiotic resistance has become a major public health threat worldwide. Infections caused by antibiotic-resistant bacteria are associated with longer hospital stays, higher healthcare costs, and increased mortality. The inappropriate use of antibiotics is one of the main factors contributing to the development of antibiotic resistance. Despite numerous efforts to promote the rational use of antibiotics, studies have shown that many healthcare providers continue to prescribe antibiotics inappropriately. This study aims to explore the factors influencing healthcare providers’ prescribing behavior and identify strategies to improve antibiotic prescribing practices.

Example 3: Social media has become an integral part of modern communication, with millions of people worldwide using platforms such as Facebook, Twitter, and Instagram. Social media has several advantages, including facilitating communication, connecting people, and disseminating information. However, social media use has also been associated with several negative outcomes, including cyberbullying, addiction, and mental health problems. This study aims to investigate the impact of social media use on mental health and identify the factors that mediate this relationship.

Purpose of Background of The Study

The primary purpose of the background of the study is to help the reader understand the rationale for the research by presenting the historical, theoretical, and empirical background of the problem.

More specifically, the background of the study aims to:

• Provide a clear understanding of the research problem and its context.
• Identify the gap in knowledge that the study intends to fill.
• Establish the significance of the research problem and its potential contribution to the field.
• Highlight the key concepts, theories, and research findings related to the problem.
• Provide a rationale for the research questions or hypotheses and the research design.
• Identify the limitations and scope of the study.

When to Write Background of The Study

The background of the study should be written early on in the research process, ideally before the research design is finalized and data collection begins. This allows the researcher to clearly articulate the rationale for the study and establish a strong foundation for the research.

The background of the study typically comes after the introduction but before the literature review section. It should provide an overview of the research problem and its context, and also introduce the key concepts, theories, and research findings related to the problem.

Writing the background of the study early on in the research process also helps to identify potential gaps in knowledge and areas for further investigation, which can guide the development of the research questions or hypotheses and the research design. By establishing the significance of the research problem and its potential contribution to the field, the background of the study can also help to justify the research and secure funding or support from stakeholders.

Advantage of Background of The Study

The background of the study has several advantages, including:

• Provides context: The background of the study provides context for the research problem by highlighting the historical, theoretical, and empirical background of the problem. This allows the reader to understand the research problem in its broader context and appreciate its significance.
• Identifies gaps in knowledge: By reviewing the existing literature related to the research problem, the background of the study can identify gaps in knowledge that the study intends to fill. This helps to establish the novelty and originality of the research and its potential contribution to the field.
• Justifies the research : The background of the study helps to justify the research by demonstrating its significance and potential impact. This can be useful in securing funding or support for the research.
• Guides the research design: The background of the study can guide the development of the research questions or hypotheses and the research design by identifying key concepts, theories, and research findings related to the problem. This ensures that the research is grounded in existing knowledge and is designed to address the research problem effectively.
• Establishes credibility: By demonstrating the researcher’s knowledge of the field and the research problem, the background of the study can establish the researcher’s credibility and expertise, which can enhance the trustworthiness and validity of the research.

Disadvantages of Background of The Study

Some Disadvantages of Background of The Study are as follows:

• Time-consuming : Writing a comprehensive background of the study can be time-consuming, especially if the research problem is complex and multifaceted. This can delay the research process and impact the timeline for completing the study.
• Repetitive: The background of the study can sometimes be repetitive, as it often involves summarizing existing research and theories related to the research problem. This can be tedious for the reader and may make the section less engaging.
• Limitations of existing research: The background of the study can reveal the limitations of existing research related to the problem. This can create challenges for the researcher in developing research questions or hypotheses that address the gaps in knowledge identified in the background of the study.
• Bias : The researcher’s biases and perspectives can influence the content and tone of the background of the study. This can impact the reader’s perception of the research problem and may influence the validity of the research.
• Accessibility: Accessing and reviewing the literature related to the research problem can be challenging, especially if the researcher does not have access to a comprehensive database or if the literature is not available in the researcher’s language. This can limit the depth and scope of the background of the study.

About the author

Muhammad Hassan

Researcher, Academic Writer, Web developer

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Case Study Research Method in Psychology

Saul Mcleod, PhD

Editor-in-Chief for Simply Psychology

BSc (Hons) Psychology, MRes, PhD, University of Manchester

Saul Mcleod, PhD., is a qualified psychology teacher with over 18 years of experience in further and higher education. He has been published in peer-reviewed journals, including the Journal of Clinical Psychology.

Learn about our Editorial Process

Olivia Guy-Evans, MSc

Associate Editor for Simply Psychology

BSc (Hons) Psychology, MSc Psychology of Education

Olivia Guy-Evans is a writer and associate editor for Simply Psychology. She has previously worked in healthcare and educational sectors.

On This Page:

Case studies are in-depth investigations of a person, group, event, or community. Typically, data is gathered from various sources using several methods (e.g., observations & interviews).

The case study research method originated in clinical medicine (the case history, i.e., the patient’s personal history). In psychology, case studies are often confined to the study of a particular individual.

The information is mainly biographical and relates to events in the individual’s past (i.e., retrospective), as well as to significant events that are currently occurring in his or her everyday life.

The case study is not a research method, but researchers select methods of data collection and analysis that will generate material suitable for case studies.

Freud (1909a, 1909b) conducted very detailed investigations into the private lives of his patients in an attempt to both understand and help them overcome their illnesses.

This makes it clear that the case study is a method that should only be used by a psychologist, therapist, or psychiatrist, i.e., someone with a professional qualification.

There is an ethical issue of competence. Only someone qualified to diagnose and treat a person can conduct a formal case study relating to atypical (i.e., abnormal) behavior or atypical development.

 Famous Case Studies

• Anna O – One of the most famous case studies, documenting psychoanalyst Josef Breuer’s treatment of “Anna O” (real name Bertha Pappenheim) for hysteria in the late 1800s using early psychoanalytic theory.
• Little Hans – A child psychoanalysis case study published by Sigmund Freud in 1909 analyzing his five-year-old patient Herbert Graf’s house phobia as related to the Oedipus complex.
• Bruce/Brenda – Gender identity case of the boy (Bruce) whose botched circumcision led psychologist John Money to advise gender reassignment and raise him as a girl (Brenda) in the 1960s.
• Genie Wiley – Linguistics/psychological development case of the victim of extreme isolation abuse who was studied in 1970s California for effects of early language deprivation on acquiring speech later in life.
• Phineas Gage – One of the most famous neuropsychology case studies analyzes personality changes in railroad worker Phineas Gage after an 1848 brain injury involving a tamping iron piercing his skull.

Clinical Case Studies

• Studying the effectiveness of psychotherapy approaches with an individual patient
• Assessing and treating mental illnesses like depression, anxiety disorders, PTSD
• Neuropsychological cases investigating brain injuries or disorders

Child Psychology Case Studies

• Studying psychological development from birth through adolescence
• Cases of learning disabilities, autism spectrum disorders, ADHD
• Effects of trauma, abuse, deprivation on development

Types of Case Studies

• Explanatory case studies : Used to explore causation in order to find underlying principles. Helpful for doing qualitative analysis to explain presumed causal links.
• Exploratory case studies : Used to explore situations where an intervention being evaluated has no clear set of outcomes. It helps define questions and hypotheses for future research.
• Descriptive case studies : Describe an intervention or phenomenon and the real-life context in which it occurred. It is helpful for illustrating certain topics within an evaluation.
• Multiple-case studies : Used to explore differences between cases and replicate findings across cases. Helpful for comparing and contrasting specific cases.
• Intrinsic : Used to gain a better understanding of a particular case. Helpful for capturing the complexity of a single case.
• Collective : Used to explore a general phenomenon using multiple case studies. Helpful for jointly studying a group of cases in order to inquire into the phenomenon.

Where Do You Find Data for a Case Study?

There are several places to find data for a case study. The key is to gather data from multiple sources to get a complete picture of the case and corroborate facts or findings through triangulation of evidence. Most of this information is likely qualitative (i.e., verbal description rather than measurement), but the psychologist might also collect numerical data.

1. Primary sources

• Interviews – Interviewing key people related to the case to get their perspectives and insights. The interview is an extremely effective procedure for obtaining information about an individual, and it may be used to collect comments from the person’s friends, parents, employer, workmates, and others who have a good knowledge of the person, as well as to obtain facts from the person him or herself.
• Observations – Observing behaviors, interactions, processes, etc., related to the case as they unfold in real-time.
• Documents & Records – Reviewing private documents, diaries, public records, correspondence, meeting minutes, etc., relevant to the case.

2. Secondary sources

• News/Media – News coverage of events related to the case study.
• Academic articles – Journal articles, dissertations etc. that discuss the case.
• Government reports – Official data and records related to the case context.
• Books/films – Books, documentaries or films discussing the case.

3. Archival records

Searching historical archives, museum collections and databases to find relevant documents, visual/audio records related to the case history and context.

Public archives like newspapers, organizational records, photographic collections could all include potentially relevant pieces of information to shed light on attitudes, cultural perspectives, common practices and historical contexts related to psychology.

4. Organizational records

Organizational records offer the advantage of often having large datasets collected over time that can reveal or confirm psychological insights.

Of course, privacy and ethical concerns regarding confidential data must be navigated carefully.

However, with proper protocols, organizational records can provide invaluable context and empirical depth to qualitative case studies exploring the intersection of psychology and organizations.

• Organizational/industrial psychology research : Organizational records like employee surveys, turnover/retention data, policies, incident reports etc. may provide insight into topics like job satisfaction, workplace culture and dynamics, leadership issues, employee behaviors etc.
• Clinical psychology : Therapists/hospitals may grant access to anonymized medical records to study aspects like assessments, diagnoses, treatment plans etc. This could shed light on clinical practices.
• School psychology : Studies could utilize anonymized student records like test scores, grades, disciplinary issues, and counseling referrals to study child development, learning barriers, effectiveness of support programs, and more.

How do I Write a Case Study in Psychology?

Follow specified case study guidelines provided by a journal or your psychology tutor. General components of clinical case studies include: background, symptoms, assessments, diagnosis, treatment, and outcomes. Interpreting the information means the researcher decides what to include or leave out. A good case study should always clarify which information is the factual description and which is an inference or the researcher’s opinion.

1. Introduction

• Provide background on the case context and why it is of interest, presenting background information like demographics, relevant history, and presenting problem.
• Compare briefly to similar published cases if applicable. Clearly state the focus/importance of the case.

2. Case Presentation

• Describe the presenting problem in detail, including symptoms, duration,and impact on daily life.
• Include client demographics like age and gender, information about social relationships, and mental health history.
• Describe all physical, emotional, and/or sensory symptoms reported by the client.
• Use patient quotes to describe the initial complaint verbatim. Follow with full-sentence summaries of relevant history details gathered, including key components that led to a working diagnosis.
• Summarize clinical exam results, namely orthopedic/neurological tests, imaging, lab tests, etc. Note actual results rather than subjective conclusions. Provide images if clearly reproducible/anonymized.
• Clearly state the working diagnosis or clinical impression before transitioning to management.

3. Management and Outcome

• Indicate the total duration of care and number of treatments given over what timeframe. Use specific names/descriptions for any therapies/interventions applied.
• Present the results of the intervention,including any quantitative or qualitative data collected.
• For outcomes, utilize visual analog scales for pain, medication usage logs, etc., if possible. Include patient self-reports of improvement/worsening of symptoms. Note the reason for discharge/end of care.

4. Discussion

• Analyze the case, exploring contributing factors, limitations of the study, and connections to existing research.
• Analyze the effectiveness of the intervention,considering factors like participant adherence, limitations of the study, and potential alternative explanations for the results.
• Identify any questions raised in the case analysis and relate insights to established theories and current research if applicable. Avoid definitive claims about physiological explanations.
• Offer clinical implications, and suggest future research directions.

5. Additional Items

• Thank specific assistants for writing support only. No patient acknowledgments.
• References should directly support any key claims or quotes included.
• Use tables/figures/images only if substantially informative. Include permissions and legends/explanatory notes.
• Provides detailed (rich qualitative) information.
• Provides insight for further research.
• Permitting investigation of otherwise impractical (or unethical) situations.

Case studies allow a researcher to investigate a topic in far more detail than might be possible if they were trying to deal with a large number of research participants (nomothetic approach) with the aim of ‘averaging’.

Because of their in-depth, multi-sided approach, case studies often shed light on aspects of human thinking and behavior that would be unethical or impractical to study in other ways.

Research that only looks into the measurable aspects of human behavior is not likely to give us insights into the subjective dimension of experience, which is important to psychoanalytic and humanistic psychologists.

Case studies are often used in exploratory research. They can help us generate new ideas (that might be tested by other methods). They are an important way of illustrating theories and can help show how different aspects of a person’s life are related to each other.

The method is, therefore, important for psychologists who adopt a holistic point of view (i.e., humanistic psychologists ).

Limitations

• Lacking scientific rigor and providing little basis for generalization of results to the wider population.
• Researchers’ own subjective feelings may influence the case study (researcher bias).
• Difficult to replicate.
• Time-consuming and expensive.
• The volume of data, together with the time restrictions in place, impacted the depth of analysis that was possible within the available resources.

Because a case study deals with only one person/event/group, we can never be sure if the case study investigated is representative of the wider body of “similar” instances. This means the conclusions drawn from a particular case may not be transferable to other settings.

Because case studies are based on the analysis of qualitative (i.e., descriptive) data , a lot depends on the psychologist’s interpretation of the information she has acquired.

This means that there is a lot of scope for Anna O , and it could be that the subjective opinions of the psychologist intrude in the assessment of what the data means.

For example, Freud has been criticized for producing case studies in which the information was sometimes distorted to fit particular behavioral theories (e.g., Little Hans ).

This is also true of Money’s interpretation of the Bruce/Brenda case study (Diamond, 1997) when he ignored evidence that went against his theory.

Breuer, J., & Freud, S. (1895).  Studies on hysteria . Standard Edition 2: London.

Curtiss, S. (1981). Genie: The case of a modern wild child .

Diamond, M., & Sigmundson, K. (1997). Sex Reassignment at Birth: Long-term Review and Clinical Implications. Archives of Pediatrics & Adolescent Medicine , 151(3), 298-304

Freud, S. (1909a). Analysis of a phobia of a five year old boy. In The Pelican Freud Library (1977), Vol 8, Case Histories 1, pages 169-306

Freud, S. (1909b). Bemerkungen über einen Fall von Zwangsneurose (Der “Rattenmann”). Jb. psychoanal. psychopathol. Forsch ., I, p. 357-421; GW, VII, p. 379-463; Notes upon a case of obsessional neurosis, SE , 10: 151-318.

Harlow J. M. (1848). Passage of an iron rod through the head.  Boston Medical and Surgical Journal, 39 , 389–393.

Harlow, J. M. (1868).  Recovery from the Passage of an Iron Bar through the Head .  Publications of the Massachusetts Medical Society. 2  (3), 327-347.

Money, J., & Ehrhardt, A. A. (1972).  Man & Woman, Boy & Girl : The Differentiation and Dimorphism of Gender Identity from Conception to Maturity. Baltimore, Maryland: Johns Hopkins University Press.

Money, J., & Tucker, P. (1975). Sexual signatures: On being a man or a woman.

Further Information

• Case Study Approach
• Case Study Method
• Enhancing the Quality of Case Studies in Health Services Research
• “We do things together” A case study of “couplehood” in dementia
• Using mixed methods for evaluating an integrative approach to cancer care: a case study

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Neuroticism and inflammatory skin diseases: a bidirectional Mendelian randomization study

• ORIGINAL PAPER
• Published: 24 May 2024
• Volume 316 , article number  213 , ( 2024 )

Cite this article

• Charalabos Antonatos 1 ,
• Alexandros Pontikas 1 ,
• Adam Akritidis 1 ,
• Sophia Georgiou 2 ,
• Alexander J. Stratigos 3 ,
• Ileana Afroditi Kleidona 3 ,
• Stamatis Gregoriou 3 ,
• Katerina Grafanaki 2 , 4 &
• Yiannis Vasilopoulos 1  

Previous observational studies have linked inflammatory skin diseases with mental health issues and neuroticism. However, the specific impact of neuroticism and its subclusters (i.e. worry, depressed affect, and sensitivity to environmental stress and adversity) on these conditions remains underexplored. In this work, we explored causal associations between common inflammatory skin diseases and neuroticism. We conducted a two-sample, bidirectional Mendelian randomization (MR) analysis using data from genome-wide association studies in psoriasis, atopic dermatitis, neuroticism and relevant genetic subclusters conducted on participants of European ancestry. Corrections for sample overlap were applied where necessary. We found that psoriasis was causally associated with increased levels of worry (odds ratio, 95% confidence intervals: 1.011, 1.006–1.016, P = 3.84 × 10 –6 ) while none of the neuroticism subclusters showed significant association with psoriasis. Sensitivity analyses revealed considerable evidence of directional pleiotropy between psoriasis and neuroticism traits. Conversely, genetic liability to atopic dermatitis did not exhibit any significant association with neuroticism traits. Notably, genetically predicted worry was linked to an elevated risk of atopic dermatitis (odds ratio, 95% confidence intervals: 1.227, 1.067–1.41, P = 3.97 × 10 –3 ). Correction for overlapping samples confirmed the robustness of these results. These findings suggest potential avenues for future interventions aimed at reducing stress and worry among patients with inflammatory skin conditions.

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Acknowledgements

C.A. was financially supported by the “Andreas Mentzelopoulos Foundation”.

This investigation was supported in part by a research grant from the National Eczema Association NEA23-CRG186.

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Laboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504, Patras, Greece

Charalabos Antonatos, Alexandros Pontikas, Adam Akritidis & Yiannis Vasilopoulos

Department of Dermatology-Venereology, School of Medicine, University of Patras, 26504, Patras, Greece

Sophia Georgiou & Katerina Grafanaki

Department of Dermatology-Venereology, Faculty of Medicine, Andreas Sygros Hospital, National and Kapodistrian University of Athens, 16121, Athens, Greece

Alexander J. Stratigos, Ileana Afroditi Kleidona & Stamatis Gregoriou

Department of Biochemistry, School of Medicine, University of Patras, 26504, Patras, Greece

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Conceptualization, CA, KG, StG, YV; software, formal analysis: CA, AP; visualization: CA; Writing-original draft preparation, CA, AP, AA; writing-review and editing: CA, AP, AA, SG, AS, IAK, StG, KG, YV. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Katerina Grafanaki or Yiannis Vasilopoulos .

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All published GWAS datasets used in the study have existing ethical permissions from institutional boards. No ethical approval was required for this manuscript.

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Summary statistics can be downloaded from: psoriasis, https://www.ebi.ac.uk/gwas/studies/GCST90019016 ; atopic dermatitis, https://www.ebi.ac.uk/gwas/studies/GCST90244787 ; neuroticism and subclusters, https://ctg.cncr.nl/software/summary_statistics/ . Code used to perform the current study is available at: https://github.com/antonatosc/Neuroticism_Skin_MR .

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Antonatos, C., Pontikas, A., Akritidis, A. et al. Neuroticism and inflammatory skin diseases: a bidirectional Mendelian randomization study. Arch Dermatol Res 316 , 213 (2024). https://doi.org/10.1007/s00403-024-03017-w

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Diet Review: Mediterranean Diet

Finding yourself confused by the seemingly endless promotion of weight-loss strategies and diet plans? In this series , we take a look at some popular diets—and review the research behind them.

What Is It?

Chances are you have heard of the Mediterranean diet. If you have a chronic condition like heart disease or high blood pressure, your doctor may even have prescribed it to you. It is often promoted to decrease the risk of heart disease, depression, and dementia.

The traditional diets of countries bordering the Mediterranean Sea differ slightly so there are different versions of the Mediterranean diet. However, in 1993 the Harvard School of Public Health, Oldways Preservation and Exchange Trust, and the European Office of the World Health Organization introduced the Mediterranean Diet Pyramid as a guide to help familiarize people with the most common foods of the region. More of an eating pattern than a strictly regimented diet plan, the pyramid emphasized certain foods based on the dietary traditions of Crete, Greece, and southern Italy during the mid-20 th century. [1,2] At that time, these countries displayed low rates of chronic disease and higher than average adult life expectancy despite having limited access to healthcare. It was believed that the diet—mainly fruits and vegetables, beans, nuts, whole grains, fish, olive oil, small amounts of dairy, and red wine—contributed to their health benefits. The pyramid also highlighted daily exercise and the beneficial social aspects of eating meals together.

How It Works

The Mediterranean diet is a primarily plant-based eating plan that includes daily intake of whole grains, olive oil, fruits, vegetables, beans and other legumes, nuts, herbs, and spices. Other foods like animal proteins are eaten in smaller quantities, with the preferred animal protein being fish and seafood. Although the pyramid shape suggests the proportion of foods to eat (e.g., eat more fruits and vegetables and less dairy foods), it does not specify portion sizes or specific amounts. It is up to the individual to decide exactly how much food to eat at each meal, as this will vary by physical activity and body size. There are additional points that make this eating plan unique:

• An emphasis on healthy fats . Olive oil is recommended as the primary added fat, replacing other oils and fats (butter, margarine). Other foods naturally containing healthful fats are highlighted, such as avocados, nuts, and oily fish like salmon and sardines; among these, walnuts and fish are high in omega-3 fatty acids.
• Choosing fish as the preferred animal protein at least twice weekly and other animal proteins of poultry, eggs, and dairy (cheese or yogurt) in smaller portions either daily or a few times a week. Red meat is limited to a few times per month.
• Choosing water as the main daily beverage, but allowing a moderate intake of wine with meals, about one to two glasses a day for men and one glass a day for women.
• Stressing daily physical activity through enjoyable activities.

This sample meal plan is roughly 2000 calories, the recommended intake for an average person. If you have higher calorie needs, you may add an additional snack or two; if you have lower calorie needs, you may remove a snack. If you have more specific nutritional needs or would like assistance in creating additional meal plans, consult with a registered dietitian.

Breakfast: 1 cup cooked steel-cut oats mixed with 2 tablespoons chopped walnuts, ¾ cup fresh or frozen blueberries, sprinkle of cinnamon

Snack: ¼ cup nuts, any type

• Beans and rice – In medium pot, heat 1 tbsp olive oil. Add and sauté ½ chopped onion, 1 tsp cumin, and 1 tsp garlic powder until onion is softened. Mix in 1 cup canned beans, drained and rinsed. Serve bean mixture over 1 cup cooked brown rice.
• 2 cups salad (e.g., mixed greens, cucumbers, bell peppers) with dressing (mix together 2 tbsp olive oil, 1 tbsp lemon juice or vinegar, ½ teaspoon Dijon mustard, ½ teaspoon garlic powder, ¼ tsp black pepper)

Snack: 1 medium orange

• 3 ounces baked salmon brushed with same salad dressing used at lunch
• 1 medium baked sweet potato with 1 tbsp soft margarine
• 1 cup chopped steamed cauliflower

Snack: 1 ounce 75% dark chocolate

The Research So Far

Research has consistently shown that the Mediterranean diet is effective in reducing the risk of cardiovascular diseases and overall mortality. [3, 4]  A study of nearly 26,000 women found that those who followed this type of diet had 25% less risk of developing cardiovascular disease over the course of 12 years. [5]  The study examined a range of underlying mechanisms that might account for this reduction, and found that changes in inflammation, blood sugar, and body mass index were the biggest drivers. Similar benefits were found in a meta-analysis of 16 prospective cohort studies following more than 22,000 women for a median of 12.5 years. [6] Those who had the highest adherence to a Mediterranean diet showed a 24% lower risk of cardiovascular disease and 23% lower risk of premature death compared with those who had the lowest adherence.

One interesting finding of this eating plan is that it dispels the myth that people with or at risk for heart disease must eat a low fat diet. Although it does matter which types of fats are chosen, the percentage of calories from fat is less of an issue. The PREDIMED study, a primary prevention trial including thousands of people with diabetes or other risk factors for heart disease found that a Mediterranean diet supplemented with extra virgin olive oil or nuts and without any fat and calorie restrictions reduced the rates of death from stroke by roughly 30%. [7] Most dietary fats were healthy fats, such as those from fatty fish, olive oil, and nuts, but total fat intake was generous at 39-42% of total daily calories, much higher than the 20-35% fat guideline as stated by the Institute of Medicine. [8]  Risk of type 2 diabetes was also reduced in the PREDIMED trial. [9]

There has also been increased interest in the diet’s effects on aging and cognitive function. [10-12] Cell damage through stress and inflammation that can lead to age-related diseases has been linked to a specific part of DNA called telomeres. These structures naturally shorten with age, and their length size can predict life expectancy and the risk of developing age-related diseases. Telomeres with long lengths are considered protective against chronic diseases and earlier death, whereas short lengths increase risk. Antioxidants can help combat cell stress and preserve telomere length, such as by eating foods that contain antioxidants nutrients like fruits, vegetables, nuts, and whole grains. These foods are found in healthy eating patterns like the Mediterranean diet. [13] This was demonstrated in a large cohort of 4676 healthy middle-aged women from the Nurses’ Health Study where participants who more closely followed the Mediterranean diet were found to have longer telomere length. [13]

Another Nurses’ Health Study following 10,670 women ages 57-61 observed the effect of dietary patterns on aging. [14] Healthy aging was defined as living to 70 years or more, and having no chronic diseases (e.g., type 2 diabetes, kidney disease, lung disease, Parkinson’s disease, cancer) or major declines in mental health, cognition, and physical function. The study found that the women who followed a Mediterranean-type eating pattern were 46% more likely to age healthfully. Increased intake of plant foods, whole grains, and fish; moderate alcohol intake; and low intake of red and processed meats were believed to contribute to this finding.

Potential Pitfalls

• There is a risk of excess calorie intake because specific amounts of foods and portion sizes are not emphasized, which could lead to weight gain. It might be helpful to use the Mediterranean Diet Pyramid, which provides guidance on specific types of foods to choose, along with a balanced plate guide such as the Harvard Healthy Eating Plate , which gives a better indication of proportions of food to eat per meal. However, it is important to note that—probably in part due to the higher intake of olive oil and less processed foods—the Mediterranean dietary pattern provides satiety and enables long term adherence. In one of the most successful weight loss trials to date, those assigned to the Mediterranean diet maintained weight loss over a period of six years. [15]
• Research supports the health benefits of a Mediterranean-style eating pattern that includes several different foods. It is the combination of these foods that appear protective against disease, as the benefit is not as strong when looking at single foods or nutrients included in the Mediterranean diet. [13] Therefore it is important to not simply add olive oil or nuts to one’s current diet but to adopt the plan in its entirety.

Bottom Line

Research supports the use of the Mediterranean diet as a healthy eating pattern for the prevention of cardiovascular diseases, increasing lifespan, and healthy aging. When used in conjunction with caloric restriction, the diet may also support healthy weight loss.

• Healthy Weight
• The Best Diet: Quality Counts
• Healthy Dietary Styles
• Other Diet Reviews
• Willett WC, Sacks F, Trichopoulou A, Drescher G, Ferro-Luzzi A, Helsing E, Trichopoulos D. Mediterranean diet pyramid: a cultural model for healthy eating. AJCN . 1995 Jun 1;61(6):1402S-6S.
• Gifford KD. Dietary fats, eating guides, and public policy: history, critique, and recommendations. Am J Med . 2002 Dec 30;113(9):89-106.
• Fung TT, Rexrode KM, Mantzoros CS, Manson JE, Willett WC, Hu FB. Mediterranean diet and incidence of and mortality from coronary heart disease and stroke in women.  Circulation . 2009 Mar 3;119(8):1093-100.
• Lopez-Garcia E, Rodriguez-Artalejo F, Li TY, Fung TT, Li S, Willett WC, Rimm EB, Hu FB. The Mediterranean-style dietary pattern and mortality among men and women with cardiovascular disease. AJCN . 2013 Oct 30;99(1):172-80.
• Ahmad S, Moorthy MV, Demler OV, Hu FB, Ridker PM, Chasman DI, Mora S. Assessment of Risk Factors and Biomarkers Associated With Risk of Cardiovascular Disease Among Women Consuming a Mediterranean Diet. JAMA Network Open . 2018 Dec 7;1(8):e185708-.
• Pant A, Gribbin S, McIntyre D, Trivedi R, Marschner S, Laranjo L, Mamas MA, Flood V, Chow CK, Zaman S. Primary prevention of cardiovascular disease in women with a Mediterranean diet: systematic review and meta-analysis. Heart . 2023 Feb 15.
• Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J, Lamuela-Raventos RM. Primary prevention of cardiovascular disease with a mediterranean diet supplemented with extra-virgin olive oil or nuts.  New England Journal of Medicine . 2018 Jun 13.  [Note: reference updated in June 2018 due to retraction and republication ]
• Food and Nutrition Board, Institute of Medicine of the National Academies. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. The National Academies Press , 2005. Accessed 10/16/17.
• Salas-Salvadó J, Bulló M, Babio N, Martínez-González MÁ, Ibarrola-Jurado N, Basora J, Estruch R, Covas MI, Corella D, Arós F, Ruiz-Gutiérrez V. Reduction in the incidence of type 2 diabetes with the Mediterranean diet. Diabetes care . 2011 Jan 1;34(1):14-9.
• Loughrey DG, Lavecchia S, Brennan S, Lawlor BA, Kelly ME. The impact of the Mediterranean diet on the cognitive functioning of healthy older adults: a systematic review and meta-analysis. Advances in Nutrition . 2017 Jul 6;8(4):571-86.
• Aridi YS, Walker JL, Wright OR. The association between the Mediterranean dietary pattern and cognitive health: a systematic review. Nutrients . 2017 Jun 28;9(7):674.
• Bhushan A, Fondell E, Ascherio A, Yuan C, Grodstein F, Willett W. Adherence to Mediterranean diet and subjective cognitive function in men. European journal of epidemiology . 2017 Nov 17:1-2.
• Crous-Bou M, Fung TT, Prescott J, Julin B, Du M, Sun Q, Rexrode KM, Hu FB, De Vivo I. Mediterranean diet and telomere length in Nurses’ Health Study: population based cohort study. BMJ . 2014 Dec 2;349:g6674.
• Samieri C, Sun Q, Townsend MK, Chiuve SE, Okereke OI, Willett WC, Stampfer M, Grodstein F. The Association Between Dietary Patterns at Midlife and Health in Aging: An Observational Study. Annals of internal medicine . 2013 Nov 5;159(9):584-91.
• Shai I, Schwarzfuchs D, Henkin Y, Shahar DR, Witkow S, Greenberg I, Golan R, Fraser D, Bolotin A, Vardi H, Tangi-Rozental O. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. NEJM . 2008 Jul 17;2008(359):229-41.

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Association between gut microbiota and anxiety disorders: a bidirectional two-sample mendelian randomization study

• Jianbing Li 1 ,
• Changhe Fan 1 ,
• Jiaqi Wang 2 ,
• Bulang Tang 2 ,
• Jiafan Cao 2 ,
• Xianzhe Hu 2 ,
• Xuan Zhao 2 &
• Caiqin Feng 1  

BMC Psychiatry volume  24 , Article number:  398 ( 2024 ) Cite this article

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There are many articles reporting that the component of intestinal microbiota implies a link to anxiety disorders (AD), and the brain-gut axis is also a hot topic in current research. However, the specific relevance between gut microbiota and AD is uncertain. We aimed to investigate causal relationship between gut microbiota and AD by using bidirectional Mendelian randomization (MR).

Genetic instrumental variable (IV) for the gut microbiota were obtained from a genome-wide association study (GWAS) involving 18,340 participants. Summary data for AD were derived from the GWAS and included 158,565 cases and 300,995 controls. We applied the inverse variance weighted (IVW) method as the main analysis. Cochran’s Q values was computed to evaluate the heterogeneity among IVs. Sensitivity analyses including intercept of MR-Egger method and MR-PRESSO analysis were used to test the horizontal pleiotropy.

We discovered 9 potential connections between bacterial traits on genus level and AD. Utilizing the IVW method, we identified 5 bacterial genera that exhibited a direct correlation with the risk of AD: genus Eubacteriumbrachygroup , genus Coprococcus3 , genus Enterorhabdus , genus Oxalobacter , genus Ruminiclostridium6 . Additionally, we found 4 bacterial genera that exhibited a negative association with AD: genus Blautia , genus Butyricicoccus , genus Erysipelotrichaceae-UCG003 and genus Parasutterella . The associations were confirmed by the sensitivity analyses.

Our study found a causal relation between parts of the gut microbiota and AD. Further randomized controlled trials are crucial to elucidate the positive effects of probiotics on AD and their particular protection systems.

Peer Review reports

Introduction

Anxiety disorders (AD), being the prevailing mental disorders, have a substantial impact on individuals and society alike [ 1 ]. The core features of AD contain indiscriminate anxiety and fear or elusion of persistent and debilitating threats, resulting in substantial medical costs and a burdensome morbidity burden [ 1 , 2 ]. As one of the most popular mental illnesses among young individuals, AD are also the earliest-onset mental disorders [ 3 ]. Amidst the COVID-19 pandemic, there has been a significant surge in the occurrence of AD among children, adolescents, and young adults globally [ 4 ]. First-line treatments for AD include medication and psychotherapy [ 5 ]. However, medication treatments carry certain side effects and risks, such as dependence, cognitive impairment, and an increased risk of heart disease [ 6 ]. The majority of individuals suffering from AD lack access to efficacious treatment options, leaving them vulnerable to relapse [ 7 , 8 ].

Many studies have shown that the occurrence of AD is related to changes in intestinal flora [ 9 , 10 ]. In social anxiety disorder (SAD), there was an increase in the relative abundance of Anaeromassillibacillus and Gordonibacter genera, whereas healthy controls exhibited an enrichment of Parasuterella [ 11 ]. Another article found a reduction in Eubacterium rectale and Fecalibacterium , as well as an increase in Escherichia , Shigella , Fusobacterium , and Ruminococcus in patients with generalized anxiety disorder (GAD) [ 12 ]. In addition, there are numerous documents demonstrating an association between the gut microbiota and mental illness, and the modulation of the gut microbiota on the gut-brain axis has garnered significant attention, such as an elevation of Enterobacteriaceae and Desulfovibrio , and a reduction of Faecalibacterium in patients with AD [ 10 , 13 , 14 , 15 , 16 , 17 ]. In the aforementioned section, it was observed that the evidence exhibits complexities and disparities, as well as some contradictory results, potentially stemming from various confounding factors among different studies.

The previous studies examining the connection between gut microbiota and AD have predominantly relied on cross-sectional designs, which limits the ability to establish a causal relationship between these associations. Therefore, unraveling the causal mechanisms behind gut microbiota-derived AD not only enhances our understanding of their pathogenesis but also provides valuable guidance for implementing microbiota-directed interventions in clinical settings to address AD. Previous Mendelian randomization (MR) studies have primarily focused on investigating the causal relationship between oral microbiota abundance and AD, or between gut microbiota and other psychiatric disorders. A systematic MR study specifically examining the causal relationship between gut microbiota and AD is still lacking in the current literature. In light of this, it is imperative to unravel the causal link between the gut microbiota and AD.

MR is a statistical approach that infers a causal relationship with exposure to a result. It leverages genetic variations linked to the exposure as a proxy for the exposure itself, enabling the assessment of the association between the exposure and the outcome [ 18 ]. Due to the highly effective findings of large-scale genome-wide association study (GWAS) at the gut microbiota and disease level, MR analysis has been abroad used in many scenarios, such as between the oral microbiome and AD, relations between genetically determined metabolites and anxiety symptoms [ 19 , 20 ]. However, there are no specific studies on the causal relationship between gut microbiota and AD. In this research, we applied a bidirectional two-sample MR method to investigate causal relationship between the gut microbiota and AD.

Materials and methods

The assumptions and study design of mr.

MR is a methodology employed to assess causal associations between variables. In order to ensure the validity of MR analysis, 3 fundamental assumptions must be met: (i) the instrumental variable (IV) exhibits a strong link to the exposure factor, (ii) the IV remains unaffected by potential confounding factors., and (iii) the IV influences the result factor solely via the exposure factor [ 21 ]. By applying strict selection criteria, appropriate SNPs were selected as IV for conducting MR analysis on two independent samples. The main aim was to examine the causal relationship between gut microbiota and AD. Furthermore, this study adhered to the guidelines outlined in the Strengthening the Reporting of Observational Studies in Epidemiology-Mendelian Randomization (STROBE-MR) framework [ 22 ] (Fig.  1 ).

A flowchart illustrating the MR analysis process for the association between gut microbiota and AD

Data sources

The data on gut microbiota GWAS used in this study were obtained from an overall meta-analysis conducted by the MiBioGen consortium. The meta-analysis comprised a total of 18,340 individuals from 24 different groups. The alliance combines human whole-genome genotyping with fecal 16 S rRNA sequencing data to perform thorough research and analysis. The large-scale, multi-ethnic genome-wide meta-analysis provided valuable insights into the genetic influences on the gut microbiome composition [ 23 ]. The GWAS data on the gut microbiome can be integrated into MR studies to explore the causal relationship between genetic variations in the gut microbiome and phenotypic traits, providing valuable insights into the role of the microbiome in human health and disease.

As for the data on genetic variants linked to AD, they were sourced from the Medical Research Council Integrative Epidemiology Unit (MRC-IEU) consortium. The cases were defined as individuals who had sought medical attention for symptoms of nervousness, anxiety, or depression. The study population consisted of individuals of European descent, comprising both males and females, and the data were sourced from the year 2018. The dataset included a total of 158,565 cases and 300,995 controls. The diagnosis was based on self-report questionnaires. Detailed information regarding the data origins for this MR study can be found in Table  1 [ 24 , 25 ].

Selection of IV

The GWAS data of exposure contained a total of 5 taxonomic levels for 211 bacterial groups. The genus level is the smallest and most specific classification level. To accurately identify each pathogenic bacterial group, we focused our analysis only on the genus level, specifically examining 131 bacterial classifications. After excluding 12 unknown groups, a total of 119 bacterial genera were included in the study.

To fulfill the demands of MR studies, our initial step involved the SNPs that exhibited an intense association with the exposure factors. However, when employing a stringent threshold of ( P  < 5 × 10 − 8 ), we obtained a limited number of IVs. Consequently, we adjusted the threshold to ( P  < 1 × 10 − 5 ) to ensure the inclusion of more IVs, thereby enabling robust and reliable results. For the selection of IVs associated with AD in the reverse MR analysis, a heightened level of stringency was implemented by applying a P -value threshold of P  < 5 × 10 − 8 .

We utilized the F-statistic to further evaluate the instrument strength. The F-statistic was determined using the formula: F =  β 2 / SE 2 . This statistic provided an assessment of the overall instrument strength [ 26 ] (Fig.  2 ). An F-statistic exceeding 10 was considered indicative of an intense conjunction between the IV and the exposure. Besides P -value threshold, the F statistic in our analysis would provide additional information on the instrument strength beyond P -value.

Assumptions in MR studies: a brief overview

Statistical analysis

The primary methodology employed in MR analysis is the inverse variance weighting (IVW) method. This approach utilizes a meta-analysis technique to combine the Wald estimates connected to individual single nucleotide polymorphisms (SNPs), providing comprehensive estimate of the collective impact of gut microbiota on AD. A crucial assumption in MR is the absence of horizontal pleiotropy, where the IV has a direct impact on the outcome variable solely through the exposure factor, without any influence from through alternative pathways. When this assumption is satisfied, the IVW method can provide estimates that are consistent and estimates [ 27 ]. In cases where a causal relationship ( P  < 0.05) is established by the IVW method, two alternative approaches, namely MR-Egger and the weighted median approach, are utilized to supplement an enrich the IVW results. The MR-Egger method relaxes the assumption of a zero intercept, and it can estimate causal effects, even pleiotropy was presented in IVs. The intercept in the MR-Egger method can indicate the extent of horizontal pleiotropy [ 27 ]. These additional methods provide valuable insights and strengthen the overall analysis by considering potential biases and alternative causal pathways.

The weighted median method can return unbiased causal estimate when only 50% of SNPs are valid [ 28 ]. In this study, we employed a significance threshold of P  < 0.05 to determine statistical significance, and the assessment of causality was expressed through odds ratios (OR) and 95% confidence intervals (CI). In instances where causal relationships were established, unidentified taxa were excluded, and additional sensitivity analyses were performed to guarantee the stability of the consequences. The false discovery rate (FDR) is utilized to control for multiple testing and reduce the likelihood of false positive findings. All of the aforementioned analyses were performed utilizing the TwoSampleMR package (version 0.5.7) in R (version 4.3.0), providing a robust and standardized approach to MR analysis.

According to the criteria for IV selection, a total of 1,531 SNPs were identified and selected as IV associated with gut microbiota. The F-statistics for these IVs all exceed 10, suggesting that the estimated coefficients are improbable to be influenced by the bias caused by weak instruments. Supplementary Tables 1 and 2 provides detailed information about the selected IVs. None of the SNPs were involved in more than one of the association results in Fig.  3 .

The scatter plots depict the causal relationship between gut microbiota and AD

The majority of gut microbiota showed no significant correlation with AD. However, using the IVW method, we identified 9 bacterial features that were significantly associated with the risk of AD on genus level (Supplementary Table 3 ). We used 3 methods, IVW, weighted median and MR-Egger, and defined P  < 0.05 for IVW method screening as a positive result.

Among them, 4 bacterial genera are negatively correlated with AD, indicating that a higher genetically predicted a lower risk of for AD (Fig. 4 and Supplementary Table 4 ). They are: genus Blautia (OR = 0.9838, 95% CI, 0.9725–0.9952, P  = 0.0056), genus Butyricicoccus (OR = 0.9859, 95% CI, 0.9739–0.9981, P  = 0.0233), genus ErysipelotrichaceaeUCG003 (OR = 0.9914, 95% CI, 0.9833–0.9995, P  = 0.0381) and genus Parasutterella (OR = 0.9911, 95% CI, 0.9823–0.9999, P  = 0.0478). Supplementary Table 4 shows the completed data. In sensitivity analysis, MR-Egger, weighted median demonstrated consistent results, except for genus ErysipelotrichaceaeUCG003 , where the MR-Egger trend was in the contrary direction compared to IVW and weighted median.

The forest plot illustrates the connections between 9 bacterial genus traits and the likelihood of developing AD

Another 5 bacterial genera showed a positive correlation with AD, genus Eubacteriumbrachygroup (OR = 1.0068, 95% CI, 1.0010–1.0127, P  = 0.0225), genus Coprococcus3 (OR = 1.0164, 95% CI, 1.0046–1.0285, P  = 0.0065), genus Enterorhabdus (OR = 1.0117, 95% CI, 1.0027–1.0208, P  = 0.0108), genus Oxalobacter (OR = 1.0067, 95% CI, 1.0009–1.0125, P  = 0.0231) and genus Ruminiclostridium6 (OR = 1.0129, 95% CI, 1.0048–1.0212, P  = 0.0019) (Fig. 4 and Supplementary Table 4 ). In the MR-Egger method, the trends of genus Eubacteriumbrachygroup are different from those of the IVW and WM methods.

In horizontal pleiotropy analysis, we used the MR-Egger method and found P -value of the MR-intercept were all greater than 0.05. In addition, further MR PRESSO analysis was conducted, ruling out the existence of horizontal pleiotropy ( P  > 0.05) (Supplementary Tables 5 and 6 ). To assess the heterogeneity of gut microbiome IVs, we employed Cochran’s Q test statistics, which revealed no heterogeneity among the gut microbiome IVs ( P  > 0.05) (Supplementary Table 7 ).

Reverse MR analyses were conducted to examine the links between the 9 bacterial genera and AD. No significant statistical relationship was observed using the IVW method: genus Eubacteriumbrachygroup (OR = 1.4058, 95% CI, 0.4060–4.8674, P  = 0.5909), genus Blautia (OR = 0.9453, 95% CI, 0.5572–1.6038, P  = 0.8348), genus Butyricicoccus (OR = 0.9834, 95% CI, 0.5704–1.6952, P  = 0.9518), genus Coprococcus3 (OR = 0.8886, 95% CI, 0.5040–1.5667, P  = 0.6831), genus Enterorhabdus (OR = 1.0383, 95% CI, 0.4168–2.5868, P  = 0.9356), genus ErysipelotrichaceaeUCG003 (OR = 0.6593, 95% CI, 0.3556–1.2221, P  = 0.1858), genus Oxalobacter (OR = 1.2849, 95% CI, 0.4021–4.1051, P  = 0.6724), genus Parasutterella (OR = 0.7245, 95% CI, 0.3713–1.4136, P  = 0.3447), genus Ruminiclostridium6 (OR = 0.7095, 95% CI, 0.3825–1.3162, P  = 0.2764) (Supplementary Tables 8 and 9 ).

In the context of this study, we used two-sample MR studies to discover the link between AD and gut microbiota. Among the 9 bacterial genus we found, 4 bacteria were negatively correlated with AD and may have a positive effect on AD, and the other 5 bacteria were positively correlated with the occurrence of AD and may promote the development of AD.

Blautia stercoris MRx0006 has been shown to alleviate social dysfunctions, monotonous behaviors, and anxiety-like behaviors relevant to autism disorders in a mouse model. MRx0006 administration at the microbial level, as observed by Paromita Sen et al., resulted in a reduction in the abundance of Alistipes putredinis, which likely underlie the observed increase in expressions of oxytocin, arginine vasopressin, and their receptors, ultimately leading to improved behavioral outcomes [ 29 ]. Butyricicoccus was also inversely associated with AD in a cross-sectional study, which is consistent with our findings [ 12 ]. Approximately 70% of individuals with autism spectrum disorder (ASD) exhibit comorbid symptoms of anxiety, and the findings from a published article confirming the decreased relative abundance of ErysipelotrichaceaeUCG003 in ASD patients further support our research results indicating a negative correlation between ErysipelotrichaceaeUCG003 and AD [ 30 ]. In a study examining SAD, the control group exhibited higher levels of the positive bacteria Parasutterella compared to the anxiety group. The term “psychobiotics” has been coined to refer to these microbes that are associated with improved mood [ 11 ]. However, in a study by Yi Zhang et al., a psychological stress model was established in C57BL/6J mice, followed by fecal microbiota transplantation using samples from stressed (S) and non-stressed (NS) mice. The results showed an increased abundance of Parasutterella in S mice and mechanistic analysis suggested its potential involvement in negative regulation of metabolism. Despite this controversial finding, our study utilized MR to reveal a negative association between Parasutterella and anxiety disorders. However, further experimental investigations are required to elucidate the underlying molecular mechanisms [ 31 ].

Five bacterial genera positively linked to anxiety may indicate that they exacerbate anxiety, but they were less reported. In a study in which consuming prebiotics altered the microbiota of healthy adults, the prebiotics reduced Eubacteriumbrachygroup but did not significantly change biomarkers of stress or mental health symptoms [ 32 ]. In previous studies on AD cases, it has been found that individuals with AD have lower levels of Coprococcus [ 33 ]. However, in our study, we observed an increasing trend in Coprococcus3 , despite belonging to the same genus. This suggests that even within the same genus, the impact of different genus may vary. In contrast to our findings, Enterorhabdus exhibited a declining pattern in a mouse model of anxiety and depression induced by social defeat [ 34 ]. This observation highlights the influence of various factors on alterations in gut microbiota, which may diverge across different species.

Nevertheless, it is crucial to acknowledge that our study has certain limitations. First, the results of this analysis are limited to European populations and may not be generalizable to other populations. Secondly, we observed that the adjusted P -values remained relatively large after multiple test adjustment. The reduced statistical power resulting from the limited sample size may also constrain our ability to detect significant associations between variables. Finally, proving the direct impact of sample types on the outcomes is challenging. However, the selection of sample types is often constrained by the availability of suitable genetic instruments and relevant data sources. The dataset we utilized does not provide specific information on the dietary habits of the individuals or their other medical conditions. Therefore, further examination and validation are needed in the future.

In summary, utilizing large-scale GWAS analysis, MR studies have disclosed a causal relationship between gut microbiota and AD. Among these, 4 bacterial genera exhibited a negative correlation, while 5 bacteria genera showed a positive correlation with AD. However, further exploration of the mechanisms linking gut microbiota to AD requires the establishment of larger GWAS databases. Several gut bacteria have been identified to reduce the occurrence of anxiety, offering promising prospects for the treatment and precaution of AD. Subsequent research should prioritize the exploration of the underlying mechanisms and the development of targeted interventions based on these findings.

Data availability

The raw data analyzed during the current study were available in public databases including IEU database(ukb-b-6991) and MiBioGen database(https://mibiogen.gcc.rug.nl). The code and data related to this study are available from the corresponding author upon reasonable request.

Abbreviations

• Anxiety disorders
• Mendelian randomization

Instrumental variable(s)

Genome-wide association study

Medical Research Council Integrative Epidemiology Unit

Inverse variance weighting

Social anxiety disorder

Generalized anxiety disorder

Strengthening the Reporting of Observational Studies in Epidemiology-Mendelian Randomization

Single nucleotide polymorphism(s)

Odds ratios

Confidence intervals

Autism spectrum disorder

Major depressive disorder

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Acknowledgements

We express our gratitude to the hospital action teams, staff, and participants from the participating hospitals for their valuable support in data collection. Additionally, we extend our appreciation to our collaborators for their assistance throughout the process.

Program of Guangzhou Science and Technology Program Project (No. 202102010115) and Guangdong Yiyang Healthcare Charity Foundation (No. JZ2022001-3).

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Jianbing Li, Changhe Fan & Caiqin Feng

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CQF designed the research framework. JBL is responsible for data and analysis methods determination as well as manuscript writing. CHF assisted in conducting the literature review. JQW was responsible for manuscript writing. BLT and JFC performed the data statistical analysis. XZH and XZ were responsible for critical revisions.

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Li, J., Fan, C., Wang, J. et al. Association between gut microbiota and anxiety disorders: a bidirectional two-sample mendelian randomization study. BMC Psychiatry 24 , 398 (2024). https://doi.org/10.1186/s12888-024-05824-x

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Received : 23 December 2023

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DOI : https://doi.org/10.1186/s12888-024-05824-x

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